A role of alpha-tocopherol and phylloquinone in the modulation of uterine contractility and reproductive function in mouse models
Abstract
Materials and methods: Both in vivo and ex vivo animal models were employed and designed to assess changes on uterine contractility and reproductive functions in the non-pregnant uterus. The effect of alpha-tocopherol and phylloquinone on spontaneous uterine contractions, oxytocin-induced uterine contractions (11.82 nM) and high KCl-induced tonic uterine contractions (80 mM) were assessed. The effect of subcutaneous administration of alphatocopherol (10 mg/kg) on reproductive hormone levels and reproductive tissues were also determined.
Results: Alpha-tocopherol increased the force of contractions while phylloquinone decreased the force of uterine contractions. Plasma levels of luteinizing hormone (P < 0.01), estrogen (P < 0.01) and progesterone (P < 0.001) were elevated in the presence of alphatocopherol after 6 days subcutaneous administration.
Conclusions: Alpha-tocopherol and phylloquinone have been shown to directly modulate uterine contractility and reproductive function and may contribute to the management and treatment of reproductive disorders.
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Bafor, E.E.; Ebidame, V.O.; Elvis-Offiah, U.B.; Omoruyi, O.; Eze, G.I.; Igbinuwen, O.; Braimoh, K.P. A role of alpha-tocopherol and phylloquinone in the modulation of uterine contractility and reproductive function in mouse models. Medicina 2017, 53, 190-202. https://doi.org/10.1016/j.medici.2017.05.002
Bafor EE, Ebidame VO, Elvis-Offiah UB, Omoruyi O, Eze GI, Igbinuwen O, Braimoh KP. A role of alpha-tocopherol and phylloquinone in the modulation of uterine contractility and reproductive function in mouse models. Medicina. 2017; 53(3):190-202. https://doi.org/10.1016/j.medici.2017.05.002
Chicago/Turabian StyleBafor, Enitome E., Victory O. Ebidame, Uloma B. Elvis-Offiah, Osemelomen Omoruyi, Gerald I. Eze, Osamwonyi Igbinuwen, and Kadiri P. Braimoh. 2017. "A role of alpha-tocopherol and phylloquinone in the modulation of uterine contractility and reproductive function in mouse models" Medicina 53, no. 3: 190-202. https://doi.org/10.1016/j.medici.2017.05.002