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Medicina
Volume 53
Issue 6
10.1016/j.medici.2018.02.001
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Review

Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies

by
Osasenaga Macdonald Ighodaro
1,2,*,
Abiola Mohammed Adeosun
1,2 and
Oluseyi Adeboye Akinloye
2
1
Department of Biochemistry, Faculty of Sciences, Lead City University, Ibadan, Nigeria
2
Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta (FUNAAB), Abeokuta, Nigeria
*
Author to whom correspondence should be addressed.
Medicina 2017, 53(6), 365-374; https://doi.org/10.1016/j.medici.2018.02.001
Submission received: 14 September 2017 / Accepted: 8 February 2018 / Published: 27 February 2018
Versions Notes

Abstract

Glycemic homeostasis refers to glucose balance or control within circulation in living organisms. It is normally and largely compromised in diabetes. The compromise when exacerbated, leads to several complications including retinopathy, nephropathy and neuropathy which are collectively known as diabetic complications and are the principal actors in co-morbidity and eventual mortality often associated with diabetes. The ability of therapeutic compounds including medicinal plants to restore glycemic balance or homeo- stasis in hyperglycemic condition is an index of their antidiabetic function and relevance. Alloxan and streptozotocin are the most popular diabetogenic agents used for assessing the antidiabetic or hypoglycemic capacity of test compounds. Notably, alloxan is far less expensive and more readily available than streptozotocin. On this ground, one will logically expect a preference for use of alloxan in experimental diabetes studies. Surprisingly, a sub meta-analysis of randomly selected studies conducted within the last one and half decade revealed otherwise. This observation necessitated the review of alloxan as a diabetogenic agent in animal studies.
Keywords: Alloxan; Diabetes mellitus; Diabetogenic agent; Streptozotocin; Animals Alloxan; Diabetes mellitus; Diabetogenic agent; Streptozotocin; Animals

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MDPI and ACS Style

Macdonald Ighodaro, O.; Mohammed Adeosun, A.; Adeboye Akinloye, O. Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies. Medicina 2017, 53, 365-374. https://doi.org/10.1016/j.medici.2018.02.001

AMA Style

Macdonald Ighodaro O, Mohammed Adeosun A, Adeboye Akinloye O. Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies. Medicina. 2017; 53(6):365-374. https://doi.org/10.1016/j.medici.2018.02.001

Chicago/Turabian Style

Macdonald Ighodaro, Osasenaga, Abiola Mohammed Adeosun, and Oluseyi Adeboye Akinloye. 2017. "Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies" Medicina 53, no. 6: 365-374. https://doi.org/10.1016/j.medici.2018.02.001

APA Style

Macdonald Ighodaro, O., Mohammed Adeosun, A., & Adeboye Akinloye, O. (2017). Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies. Medicina, 53(6), 365-374. https://doi.org/10.1016/j.medici.2018.02.001

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