Effect of Regular Exercise and Functional Beverages on Changes in Body Weight and Waist Circumference in Healthy Japanese Subjects
1
Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto 606-8501, Japan
2
Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto 606-8501, Japan
*
Author to whom correspondence should be addressed.
Medicina 2018, 54(4), 64; https://doi.org/10.3390/medicina54040064
Submission received: 24 July 2018
/
Revised: 31 August 2018
/
Accepted: 3 September 2018
/
Published: 4 September 2018
Abstract
:Background and objectives: The effects on anthropometry of several lipid-related foods for specified health uses (FOSHU) approved in Japan are not well known. We examined the effects of regular exercise and lipid-related FOSHU beverages on changes in body weight (BW) and waist circumference (WC) among factory and office workers. Materials and Methods: A total of 3002 subjects aged 20 years or older (2497 men and 505 women) received health check-ups in 2015 and 2016 and completed a lifestyle questionnaire. The association between regular exercise or lipid-related FOSHU beverage intake and changes in BW or WC were evaluated using trend test and linear regression analysis. Results: Regular exercise (≥1/week) was reported by 774 subjects (25.8%), and regular consumption of lipid-related FOSHU beverages (≥1/week) was reported by 1168 subjects (38.9%). The significant association between lipid-related FOSHU beverage intake and changes in BW was only observed among subjects with regular exercise (p for trend = 0.042). In the multivariable analysis, sex, older age, baseline weight, baseline body mass index (BMI), and regular exercise behavior were significantly associated with smaller changes in BW (p < 0.05). In WC, only the baseline values of WC and BMI were associated with one-year changes of WC. Conclusions: The combination of regular exercise and lipid-related FOSHU may be effective in maintaining BW.
1. Introduction
The prevalence of obesity and the number of overweight individuals is increasing worldwide, regardless of age and sex [1]. Global obesity is estimated to reach a prevalence rate of 18% in men and 21% in women by 2025, with both the global and regional mean body mass index (BMI) of adults increasing [2]. Occupation-related physical activity has decreased over the past 50 years, while the daily energy expenditure in the United States has dropped by more than 100 calories for men and women [3]. An increase in food energy supply and a decrease in physical activity are thought to be some of the drivers of the global obesity pandemic [4]. Therefore, the World Health Organization developed the Global Action Plan, which includes the voluntary global target to reduce the prevalence of insufficient physical activity and halt the rise in obesity [5]. Improvement in eating behavior and physical activity were set as targets both globally and regionally. The national movement to promote lifestyle improvements in Japan produced targets for reducing obesity and increasing regular exercise [6].
Foods for specified health uses (FOSHU) are food products that contain functional components which can have positive effects on health conditions or functions; declarations for specific health claims on food labels are approved for these foods [7]. FOSHU products are expected to improve dietary habits and contribute to health maintenance through the daily consumption of healthy food. Some FOSHU beverages are approved for health use and targeted toward individuals with high body fat or serum triglyceride levels. The ingredients in these FOSHU products are tea catechins, oolong tea polymerized polyphenols, coffee mannooligosaccharides, resistant maltodextrin, and quercetin glucosides. FOSHU products help suppress elevated serum triglyceride levels after meals, lower serum cholesterol or low-density lipoprotein cholesterol levels, or reduce body fat based on the findings of clinical studies using a small number of healthy subjects [8,9,10,11]. Although many of the lipid-related FOSHU beverages are not approved for making claims regarding changes in anthropometry, many clinical studies with short-term interventions have reported the association between FOSHU beverage intakes and changes in body weight (BW) or abdominal obesity with tea catechins [12,13,14,15,16], oolong tea [17], mannooligosaccharides [18,19,20,21], and quercetin [22,23,24]. However, the long-term effects of habitual consumption of FOSHU beverages on anthropometric data have not been adequately studied. Therefore, we aimed to evaluate the effect of lipid-related FOSHU beverage consumption and regular exercise on changes in BW and waist circumference (WC) using health check-up data of a Japanese cohort of factory and office workers.
2. Materials and Methods
2.1. Study Subjects
The cohort used in this study included a total of 7481 factory and office workers in Japan. Of these, 3962 completed a questionnaire of their medical history and lifestyle (response rate: 53.0%). Potential study subjects who were excluded included 296 subjects without annual health check-ups in 2015 and/or 2016, 139 who did not provide consent, 396 who were on medications, 170 who were pregnant, and 23 subjects who were involved in this study; therefore, the final study cohort consisted of 3002 subjects. The self-reported questionnaire included information on past medication, past medical history, past pregnancy and delivery, frequency of regular exercise (30 min or longer: “How often do you exercise for 30 minutes or longer?”), and number of lipid-related FOSHU beverages consumed (in units of bottles: “How often do you take lipid-related FOSHU beverages?”).
2.2. Data Collection
Body weight was measured while participants wore light clothing. Body height, weight, and WC were measured by a trained nurse at the health check-up. BW, BMI, WC, frequency of regular exercise, and number of FOSHU beverage bottles consumed were evaluated according to sex and age group. The reported volume of bottled FOSHU beverages consumed in the questionnaire ranged from 200–2000 mL. The suggested dose for the majority of the FOSHU beverages was either one bottle, or 200–500 mL with a meal. Hence, the total number of FOSHU beverage bottles consumed corresponded to the number of 200–500 mL bottles, depending on the volume of the bottle for each product. This study was conducted according to the Declaration of Helsinki, and the ethics committee of Kyoto University approved the use of these data and the study protocol (approval number: R1069). This study was conducted in accordance with the Ethical Guidelines for Medical and Health Research Involving Human Subjects in Japan.
2.3. Statistical Methods
Categorical variables were expressed as number and percentage. Continuous variables were summarized as mean (standard deviation) or median (interquartile range, IQR) according to the distribution of the data. The baseline BW, BMI, WC, frequency of regular exercise, and the number of lipid-related FOSHU beverages consumed were reported according to sex and age groups. Changes in BW and WC were calculated by subtracting the 2015 values from those of 2016, and the mean and standard error were presented. The p for trend was calculated using the Jonckheere-Terpstra test for ordinal variables, and the Cochran–Armitage trend test was used for categorical variables. The associations between beverage intake and changes in WC and BW were assessed separately among those who reported exercising at least once per week (n = 774) and those who reported no regular exercise (n = 2227). Sex-adjusted, age-adjusted, and multivariable-adjusted linear regression analyses were performed to examine the association among changes in BW, BMI, WC, and baseline factors. Multivariable-adjustment was performed for sex, age, baseline BW, BMI, or WC, frequency of regular exercise, and lipid-related FOSHU beverage intake. Two-sided tests were performed with a significance level of p < 0.05. Stata version 14.2 (STATA Corp., College Station, TX, USA) and SAS version 9.4 (SAS Institute Inc., Cary, NC, USA) were used for the statistical analysis.
3. Results
3.1. Subjects
Baseline characteristics of the study subjects are reported in Table 1. The WC increased with age among both men and women. Regular exercise was reported by 67.6% of men and 54.5% of women. Regular consumption of lipid-related FOSHU beverages (≥1/week) was reported by 40.2% of men and 32.5% of women. The ingredients of the lipid-related FOSHU beverages were quercetin glucosides (n = 1102), oolong tea polymerized polyphenols (n = 461), resistant maltodextrin (n = 107), tea catechins (n = 14), coffee bean mannooligosaccharides (n = 5), and others (n = 17).
3.2. Changes in Weight, BMI, and WC
Changes in BW and WC among men increased with age (all p for trend <0.001; Table 2), but no associations were observed among women (p for trend= 0.753, and 0.982, respectively). Changes in BW decreased with greater frequency of regular exercise in both men and women (p for trend = 0.012, and 0.044 respectively; Table 3).
3.3. Lipid-Related FOSHU Beverage Intake
Table 4 shows the association between lipid-related FOSHU beverage intake and changes in BW and WC. Changes in BW and WC were not associated with the frequency of lipid-related FOSHU beverage intake (p for trend = 0.731, and 0.269, respectively). The significant association between lipid-related FOSHU beverage intake and changes in BW was only observed among subjects with regular exercise (p for trend = 0.042; Table 5).
3.4. Multivariable-Adjusted Regression
Sex-adjusted, age-adjusted, and multivariable-adjusted regression analyses between baseline factors and changes in BW and WC are shown in Table 6. Older age and regular exercise behavior were associated with smaller changes in BW in the sex- and age-adjusted model. The baseline WC was also significantly associated with changes in WC. In the multivariable analysis, sex, older age, baseline weight, baseline BMI, and regular exercise behavior were significantly associated with smaller changes in BW. In WC, only the baseline values of WC and BMI were associated with one-year changes of WC.
4. Discussion
Using the health check-up data of Japanese factory and office workers, we examined associations between frequency of regular exercise and/or lipid-related FOSHU beverage intake with changes in BW and WC. We found a significant association between a greater frequency of lipid-related FOSHU beverages consumed with smaller changes in BW in subjects with regular exercise, but we did not observe this trend in those without regular exercise. This is the first study to demonstrate an association between lipid-related FOSHU beverage consumption and changes in BW and WC according to exercise frequency.
The observation period of this study was 12 months, which is much longer than most clinical studies evaluating the anti-obesity effect of lipid-related FOSHU beverages and their ingredients. Although some previous studies have used relatively longer observation periods, none were longer than 24 weeks. In previous studies, tea catechins were administered to healthy subjects for 12 [12,13,14,15,16] and 20 weeks [13]. BW, WC, abdominal fat, and visceral and subcutaneous fat have been shown to significantly decrease in high-dose catechin groups compared to low-dose or control groups [12,13,14,15]. Brown adipose tissue, which regulates non-shivering thermogenesis and adiposity, has been shown to increase significantly in the catechin group compared to the control group in healthy young women [16]. In another study, oolong tea polyphenols were given to healthy and overweight (25 kg/m2 ≤ BMI < 30 kg/m2) subjects for 12 weeks; abdominal fat area reduced significantly compared to the control group [17]. Similarly, coffee-derived mannooligosaccharides were given to healthy and overweight Japanese subjects for 12 weeks [18,19,20]. Abdominal, subcutaneous, and visceral fat areas significantly reduced compared to the control group [18,19]. However, in another study involving 60 overweight subjects from multiple ethnicities, total body volume, subcutaneous, and visceral adipose tissue significantly decreased compared to placebo in men, but not in women [20]. When indigestible dextrin was given to male subjects for 3 months, body fat decreased in all subjects, while visceral fat decreased in subjects with obesity [21]. Furthermore, when quercetin was administered to overweight and obese subjects for 12 [22,23] and 24 weeks [24], WC and abdominal, visceral, and subcutaneous fat areas were significantly reduced in the quercetin group compared to the placebo group.
The mechanisms of anti-obesity effects of the ingredients in lipid-related FOSHU beverages have been previously studied in basic and clinical studies. BW reduction mediated by the ingredients in tea are thought to be a result of decreased absorption of lipids and proteins, which reduces caloric intake and activates adenosine monophosphate (AMP)-activated protein kinase, which then suppresses adipogenesis and increases fatty acid oxidation [25]. The anti-obesity effects of oolong tea might be due to its inhibitory effect on pancreatic lipase activity [26]. Oolong tea polyphenol showed strong inhibition against pancreatic lipase, which leads to an inhibited absorption of lipids from the intestine and an increase in the excretion of these compounds [27]. Polyphenol-enriched oolong tea has been shown to increase fecal lipid excretion in healthy subjects [28]. Quercetin may show anti-obesity effects that are mediated by the attenuation of adipogenesis through the up-regulation of AMP-activated protein kinase (AMPK) and an increase in apoptosis of adipocytes through mitogen-activated protein kinase [29]. Quercetin reduces diet-induced liver fat accumulation by regulating lipogenesis in the transcription level [30]. Resistant maltodextrin suppresses lipid absorption and promotes the excretion of lipids into feces by delaying the release of fatty acid from the micelles, which is one of the first phases of the lipid absorption process [31]. However, the effects and mechanisms of lipid-related FOSHU beverage intake on long-term changes in BW or WC are unclear, and further studies are warranted to explain the long-term effects of these beverages.
In this study, greater frequencies of lipid-related FOSHU beverage intake combined with regular exercise were associated with smaller changes in BW; however, this association was not significant in the multivariable model. Baseline WC and regular exercise had a stronger effect on changes in WC compared to lipid-related FOSHU beverage consumption. Changes in WC were significantly associated with the frequency of lipid-related FOSHU beverage consumption and regular exercise. Mechanisms between the ingredients of lipid-related FOSHU beverages and regular exercise are not well studied. Voluntary exercise and green tea enhance the expression of genes related to energy utilization in mice fed a high-fat diet [32]. Therefore, lipid-related FOSHU beverage intake combined with regular exercise might be suggested for health benefits. Further studies are needed to examine the conditions under which the health benefits of lipid-related FOSHU beverages can be maximized.
The strength of this study is the relatively large number of subjects. However, there are also several limitations. First, information on food intake could not be collected. Second, information on the precise amount of lipid-related FOSHU beverages that were consumed could not be obtained, since our questionnaire was completed based on the number of lipid-related FOSHU beverages consumed without additional conditions. The recommended ingestion of lipid-related FOSHU beverages is 1–2 bottles per day. The highest lipid-related FOSHU beverage intake group (≥5 bottles/week) were presumed to be within the recommended range. Third, information regarding regular exercise and the amount of lipid-related FOSHU beverages were collected through a self-reported questionnaire; hence, misclassification could have occurred. This was an exploratory study and the questionnaire was not validated; therefore, additional studies with validated questionnaires are needed.
5. Conclusions
Changes in BW were smaller with greater frequencies of FOSHU intake with regular exercise behavior, but not among those without regular exercise behavior. The results of this study suggested that the combination of regular exercise and lipid-related FOSHU intake may be effective in maintaining BW.
Author Contributions
Conceptualization, K.I., M.T., K.K. Data Curation, M.T., T.S., Formal Analysis, K.I., M.T., T.S. Funding Acquisition, K.K. Methodology, K.I., M.T. Project Administration, M.T., K.K. Supervision, K.K. Writing—Original Draft Preparation, K.I., M.T. Validation, M.T., T.S. Writing—Review & Editing, K.I., T.S., M.T., K.K. All authors read and approved the final manuscript.
Funding
This research was funded by Suntory Beverage & Food Ltd. (No. 150170600009).
Acknowledgments
None.
Conflicts of Interest
K.K. receives consulting fees or speaker honoraria from: Takeda Pharmaceutical Co., Ltd., Kaken Pharmaceutical Co., Ltd., AbbVie Inc., Eisai Co., Ltd., Daiichi Sankyo Co., Ltd., Santen Pharmaceutical Co., Ltd., Bayer Yakuhin Ltd., Chugai Pharmaceutical Co., Ltd., Otsuka Pharmaceutical Co., Ltd., Olympus Corporation, Shin Nippon Biomedical Laboratories, LTD., Japan Medical Data Center Co., Ltd.; research funds from: Olympus Corporation, Sumitomo Dainippon Pharma Co., Ltd., Bayer Yakuhin Ltd., Stella Pharma Corporation, Novartis Pharma K.K., CMIC Co., Ltd., Amgen Astellas BioPharma K.K., Suntory Beverage & Food Ltd., Medical Platform Co., Ltd.; and holds stocks of: School Health Record Center Co., Ltd., Real World Data Co., Ltd. This study was sponsored by Suntory Beverage & Food Ltd. Suntory Beverage & Food Ltd. collected and anonymized the data, which was provided by the independent external vendor to the Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University. The sponsor was also involved in the discussion regarding the study design and interpretation of data. The draft was reviewed by the representatives of the sponsor for comments, but the manuscript was finalized for this submission by the authors without any control by the sponsors. T.U., K.I., and M.T. declare no conflicts of interest.
References
- Ng, M.; Fleming, T.; Robinson, M.; Thomson, B.; Graetz, N.; Margono, C.; Mullany, E.C.; Biryukov, S.; Abbafati, C.; Abera, S.F.; et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014, 384, 766–781. [Google Scholar] [CrossRef]
- NCD Risk Factor Collaboration (NCD-RisC). Trends in adult body-mass index in 200 countries from 1975 to 2014: A pooled analysis of 1698 population-based measurement studies with 19·2 million participants. Lancet 2016, 387, 1377–1396. [Google Scholar] [CrossRef]
- Church, T.S.; Thomas, D.M.; Tudor-Locke, C.; Katzmarzyk, P.T.; Earnest, C.P.; Rodarte, R.Q.; Martin, C.K.; Blair, S.N.; Bouchard, C. Trends over 5 decades in U.S. occupation-related physical activity and their associations with obesity. PLoS ONE 2011, 6, e19657. [Google Scholar] [CrossRef] [PubMed]
- Swinburn, B.A.; Sacks, G.; Hall, K.D.; McPherson, K.; Finegood, D.T.; Moodie, M.L.; Gortmaker, S.L. The global obesity pandemic: Shaped by global drivers and local environments. Lancet 2011, 378, 804–814. [Google Scholar] [CrossRef]
- World Health Organization. Global Action Plan for the Prevention and Control of NCDs 2013–2020. Available online: http://www.who.int/nmh/events/ncd_action_plan/en/ (accessed on 13 March 2018).
- Minister of Health, Labour and Welfare. Ministerial Notification No. 430 of the Ministry of Health, Labour and Welfare. 10 July 2012. Available online: http://www.mhlw.go.jp/stf/seisakunitsuite/bunya/kenkou_iryou/kenkou/kenkounippon21.html/ (accessed on 13 March 2018).
- Regulatory Systems of Health Claims in Japan. Consumer Affairs Agency, Japan. June 2011. Available online: http://www.caa.go.jp/en/ (accessed on 13 March 2018).
- Kim, A.; Chiu, A.; Barone, M.K.; Avino, D.; Wang, F.; Coleman, C.I.; Phung, O.J. Green tea catechins decrease total and low-density lipoprotein cholesterol: A systematic review and meta-analysis. J. Am. Diet. Assoc. 2011, 111, 1720–1729. [Google Scholar] [CrossRef] [PubMed]
- Hara, Y.; Moriguchi, A.; Kusumoto, A.; Nakai, M.; Ono, Y.; Abe, K.; Ohta, H.; Shibata, H.; Kiso, Y.; Egawa, K. Suppressive effect of oolong tea polymerized polyphenols-enriched oolong tea on postprandial serum triglyceride elevation. Jpn. Pharmacol. Ther. 2004, 32, 335–342. [Google Scholar]
- Kumao, T.; Fujii, S.; Asakawa, A.; Takehara, I.; Fukuhara, I. Effect of coffee drink containing mannooligosaccharides on total amount of excreted fat in healthy adults. J. Health Sci. 2006, 52, 482–485. [Google Scholar] [CrossRef]
- Kishimoto, Y.; Oga, H.; Tagami, H.; Okuma, K.; Gordon, D.T. Suppressive effect of resistant maltodextrin on postprandial blood triacylglycerol elevation. Eur. J. Nutr. 2007, 46, 133–138. [Google Scholar] [CrossRef] [PubMed]
- Hase, T.; Komine, Y.; Meguro, S.; Takeda, Y.; Takahshi, H.; Matsui, Y.; Inaoka, S.; Katsuragi, Y.; Tokimitsu, I.; Shimasaki, H.; et al. Anti-obesity effects of tea catechins in humans. J. Oleo Sci. 2001, 50, 599–605. [Google Scholar] [CrossRef]
- Nagao, T.; Meguro, S.; Soga, S.; Otsuka, S.; Tomonobu, K.; Fukumoto, S.; Chikama, A.; Mori, K.; Yuzawa, M.; Watanabe, H.; et al. Tea catechins suppress accumulation of body fat in humans. J. Oleo Sci. 2001, 50, 717–728. [Google Scholar] [CrossRef]
- Nagao, T.; Komine, Y.; Soga, S.; Meguro, S.; Hase, T.; Tanaka, Y.; Tokimitsu, I. Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men. Am. J. Clin. Nutr. 2005, 81, 122–129. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Nagao, T.; Hase, T.; Tokimitsu, I. A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity 2007, 15, 1473–1483. [Google Scholar] [CrossRef] [PubMed]
- Nirengi, S.; Amagasa, S.; Homma, T.; Yoneshiro, T.; Matsumiya, S.; Kurosawa, Y.; Sakane, N.; Ebi, K.; Saito, M.; Hamaoka, T. Daily ingestion of catechin-rich beverage increases brown adipose tissue density and decreases extramyocellular lipids in healthy young women. SpringerPlus 2016, 5, 1363. [Google Scholar] [CrossRef] [PubMed]
- Nakamura, J.; Teramoto, T.; Abe, K.; Ohta, H.; Kiso, Y.; Takehara, I.; Fukuhara, I.; Hirano, T. Lowering effects on visceral fat of the OTPP (oolong Tea Polymerized Polyphenols) enriched oolong tea (FOSHU “KURO-Oolong Tea OTPP”) in over weight volunteers. Jpn. Pharmacol. Ther. 2007, 35, 661–671. [Google Scholar]
- Asano, I.; Fujii, S.; Ozaki, K.; Takahara, I.; Yano, Y.; Fukuhara, I. Effects of coffee beverage containing mannooligosaceharicles from coffee on human abdominal fat by long term ingestion. Jpn. J. Food Eng. 2005, 6, 133–141. [Google Scholar]
- Kumao, T.; Fujii, S.; Takehara, I.; Fukuhara, I. Effect of soluble coffee containing mannooligosaccharides on human body fat by long-term ingestion. Jpn. Pharmacol. Ther. 2007, 35, 673–679. [Google Scholar]
- St-Onge, M.P.; Salinardi, T.; Herron-Rubin, K.; Black, R.M. A weight-loss diet including coffee-derived mannooligosaccharides enhances adipose tissue loss in overweight men but not women. Obesity 2012, 20, 343–348. [Google Scholar] [CrossRef] [PubMed]
- Kishimoto, Y.; Wakabayashi, S.; Tokunaga, K. Effects of long-term administration of indigestible dextrin on visceral fat accumulation. J. Jpn. Assoc. Diet. Fiber Res. 2000, 4, 9–65. [Google Scholar]
- Yoshimura, M.; Maeda, A.; Takehara, I.; Abe, K.; Ohta, H.; Kiso, Y.; Fukuhara, I.; Sakane, N. Body fat reducing effect and safety of the beverage containing polyphenols derived from Japanese pagoda tree (enzymatically modified isoquercitrin) in overweight and obese subjects. Jpn. Pharmacol. Ther. 2008, 36, 919–930. [Google Scholar]
- Saito, K.; Tanaka, T.; Obata, H.; Nakamura, J.; Fukui, N.; Tonozuka, N. Body fat reducing effect and safety evaluation of long-term consumption of tea containing quercetin glucosides in obese subjects. Jpn. Pharmacol. Ther. 2015, 43, 181–194. [Google Scholar]
- Yoshimura, M.; Maeda, A.; Nakamura, J.; Kitagawa, Y.; Shibata, H.; Fukuhara, I. Body fat reducing effect of continuous consumption of the beverage containing quercetin glucosides (enzymatically modified isoquercitrin) in obese subjects. Jpn. Pharmacol. Ther. 2012, 40, 901–914. [Google Scholar]
- Yang, C.S.; Zhang, J.; Zhang, L.; Huang, J.; Wang, Y. Mechanisms of body weight reduction and metabolic syndrome alleviation by tea. Mol. Nutr. Food Res. 2016, 60, 160–174. [Google Scholar] [CrossRef] [PubMed]
- Han, L.K.; Takaku, T.; Li, J.; Kimura, Y.; Okuda, H. Anti-obesity action of oolong tea. Int. J. Obes. 1999, 23, 98–105. [Google Scholar] [CrossRef] [Green Version]
- Nakai, M.; Fukui, Y.; Asami, S.; Toyoda-Ono, Y.; Iwashita, T.; Shibata, H.; Mitsunaga, T.; Hashimoto, F.; Kiso, Y. Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro. J. Agric. Food Chem. 2005, 53, 4593–4598. [Google Scholar] [CrossRef] [PubMed]
- Hsu, T.F.; Kusumoto, A.; Abe, K.; Hosoda, K.; Kiso, Y.; Wang, M.F.; Yamamoto, S. Polyphenol-enriched oolong tea increases fecal lipid excretion. Eur. J. Clin. Nutr. 2006, 60, 1330–1336. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Ahn, J.; Lee, H.; Kim, S.; Park, J.; Ha, T. The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. Biochem. Biophys. Res. Commun. 2008, 373, 545–549. [Google Scholar] [CrossRef] [PubMed]
- Jung, C.H.; Cho, I.; Ahn, J.; Jeon, T.I.; Ha, T.Y. Quercetin reduces high-fat diet-induced fat accumulation in the liver by regulating lipid metabolism genes. Phytother. Res. 2013, 27, 139–143. [Google Scholar] [CrossRef] [PubMed]
- Kishimoto, Y.; Yoshikawa, Y.; Miyazato, S.; Oga, H.; Yamada, T.; Tagami, H.; Hashizume, C.; Yamamoto, K. Effect of resistant maltodextrin on digestion and absorption of lipids. J. Health Sci. 2009, 55, 838–844. [Google Scholar] [CrossRef]
- Sae-Tan, S.; Rogers, C.J.; Lambert, J.D. Voluntary exercise and green tea enhance the expression of genes related to energy utilization and attenuate metabolic syndrome in high fat fed mice. Mol. Nutr. Food Res. 2014, 58, 1156–1159. [Google Scholar] [CrossRef] [PubMed]
Table 1.
Baseline characteristics of the study subjects according to sex and age groups.
| All | Age (years) | p for Trend | ||||
|---|---|---|---|---|---|---|
| 20–29 | 30–39 | 40–49 | ≥50 | |||
| Men | (n = 2497) | (n = 384) | (n = 952) | (n = 736) | (n = 425) | |
| BW, kg | 68.6 (62.4, 75.7) | 66.4 (60.5, 73.4) | 69.1 (69.1, 77.2) | 69.7 (63.9, 76.2) | 67.6 (61.8, 73.5) | 0.373 |
| WC, cm | 83.0 (77.0, 89.0) | 78.0 (74.0, 83.9) | 82.5 (77.0, 89.0) | 84.5 (79.0, 90.0) | 84.0 (79.1, 90.0) | <0.001 |
| Regular exercise frequency | ||||||
| <1/month | 783 (32.9) | 95 (25.3) | 294 (31.7) | 270 (39.1) | 124 (31.8) | 0.036 |
| 1/month–1/week | 1053 (44.2) | 188 (50.1) | 438 (47.3) | 274 (39.7) | 153 (39.2) | <0.001 |
| 2–4/week | 489 (20.5) | 80 (21.3) | 179 (19.3) | 136 (19.7) | 94 (24.1) | 0.651 |
| ≥5/week | 58 (2.4) | 12 (3.2) | 16 (1.7) | 11 (1.6) | 19 (4.9) | 0.208 |
| Lipid-related FOSHU beverage intake, bottle/week | ||||||
| <1 | 1493 (59.8) | 251 (65.4) | 544 (57.1) | 421 (57.2) | 277 (65.2) | 0.830 |
| 1–2 | 438 (17.5) | 70 (18.2) | 196 (20.6) | 119 (16.2) | 53 (12.5) | 0.002 |
| 3–4 | 304 (12.2) | 37 (9.6) | 119 (12.5) | 99 (13.5) | 49 (11.5) | 0.384 |
| ≥5 | 262 (10.5) | 26 (6.8) | 93 (9.8) | 97 (13.2) | 46 (10.8) | 0.012 |
| Women | (n = 505) | (n = 163) | (n = 118) | (n = 132) | (n = 92) | |
| BW, kg | 51.0 (46.5, 56.0) | 50.7 (47.4, 54.4) | 50.8 (45.5, 56.1) | 52.4 (46.5, 57.2) | 51.6 (46.1, 55.4) | 0.641 |
| WC, cm | 73.5 (68.5, 79.5) | 70.8 (66.5, 75.4) | 73.0 (68.8, 78.5) | 76.0 (71.0, 82.3) | 76.7 (71.6, 85.2) | <0.001 |
| Regular exercise frequency | ||||||
| <1/months | 210 (45.3) | 60 (36.8) | 48 (40.7) | 60 (45.5) | 42 (45.7) | 0.103 |
| 1/month–1/week | 181 (39.0) | 65 (39.9) | 48 (40.7) | 43 (32.6) | 25 (27.2) | 0.026 |
| 2–4/week | 72 (15.5) | 31 (19.0) | 16 (13.6) | 14 (10.6) | 11 (12.0) | 0.057 |
| ≥5/week | 1 (0.2) | 1 (0.6) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0.505 |
| Lipid-related FOSHU beverage intake, bottle/week | ||||||
| <1 | 300 (59.4) | 93 (57.1) | 72 (61.0) | 78 (59.1) | 57 (62.0) | 0.513 |
| 1–2 | 78 (15.5) | 39 (23.9) | 17 (14.4) | 16 (12.1) | 6 (6.5) | <0.001 |
| 3–4 | 49 (9.7) | 18 (11.0) | 15 (12.7) | 11 (8.3) | 5 (5.4) | 0.118 |
| ≥5 | 37 (7.3) | 7 (4.3) | 8 (6.8) | 12 (9.1) | 10 (10.9) | 0.037 |
BW, body weight; FOSHU, food for specified health uses; WC, waist circumference. Values are represented as median (IQR) for continuous variables and numbers (%) for categorical variables. SD, standard deviation. p for trend were calculated using the Jonckheere-Terpstra test for ordinal variables, and the Cochran–Armitage trend test was used for categorical variables.
Table 2.
One-year changes in weight, and WC according to sex and age groups.
| Age (years) | p for Trend | ||||
|---|---|---|---|---|---|
| 20–29 | 30–39 | 40–49 | ≥50 | ||
| Men (n = 2497) | |||||
| BW, kg/year | 0.86 (0.15) | 0.35 (0.08) | 0.10 (0.09) | 0.15 (0.10) | <0.001 |
| WC, cm/year | 1.09 (0.20) | 0.19 (0.12) | −0.10 (0.15) | 0.29 (0.21) | <0.001 |
| Women (n = 505) | |||||
| BW, kg/year | 0.31 (0.17) | 0.13 (0.18) | 0.72 (0.13) | 0.03 (0.17) | 0.753 |
| WC, cm/year | 0.86 (0.38) | −0.04 (0.40) | 0.38 (0.43) | 0.22 (0.60) | 0.982 |
BW, body weight; WC, waist circumference. Values are represented as means (SE). SE, standard error. p for trend were calculated using the Jonckheere-Terpstra test.
Table 3.
Changes in BW, and WC according to regular exercise frequency.
| Regular Exercise Frequencies | p for Trend | ||||
|---|---|---|---|---|---|
| <1/mo | 1/mo–1/wk | ≥5/wk | 2–4/wk | ||
| Men (n = 2497) | |||||
| BW, kg/year | 0.43 (0.10) | 0.37 (0.08) | 0.24 (0.11) | −0.61 (0.33) | 0.012 |
| WC, cm/year | 0.35 (0.12) | 0.35 (0.10) | 0.35 (0.15) | −0.79 (0.40) | 0.192 |
| Women (n = 505) | |||||
| BW, kg/year | 0.63 (0.13) | 0.19 (0.13) | −0.04 (0.28) | −1.1 (0.0) | 0.044 |
| WC, cm/year | 0.66 (0.23) | 0.66 (0.31) | −0.05 (0.45) | −6.5 (0.0) | 0.555 |
BW, body weight; WC, waist circumference. Values are represented as means (SE). mo, month; SE, standard error; wk, week. p for trend were calculated using the Jonckheere-Terpstra test.
Table 4.
Mean change in BW and WC according to lipid-related FOSHU beverage intake.
| Lipid-Related FOSHU Beverage Intake | p for Trend | ||||
|---|---|---|---|---|---|
| <1/wk | 1–2/wk | 3–4/wk | ≥5/wk | ||
| All (n = 3002) | (n = 1793) | (n = 516) | (n = 353) | (n = 299) | |
| BW, kg/year | 0.35 (0.05) | 0.44 (0.11) | 0.29 (0.15) | 0.01 (0.17) | 0.731 |
| WC, cm/year | 0.35 (0.10) | 0.34 (0.15) | 0.37 (0.20) | −0.16 (0.20) | 0.269 |
BW, body weight; WC, waist circumference. Values are represented as mean (standard error). p for trend were calculated using the Jonckheere-Terpstra test.
Table 5.
Mean change in BW and WC according to the number of lipid-related FOSHU beverage intake with or without regular exercise.
Table 5.
Mean change in BW and WC according to the number of lipid-related FOSHU beverage intake with or without regular exercise.
| Lipid-Related FOSHU Beverage Intake | p for Trend | ||||
|---|---|---|---|---|---|
| <1/wk | 1–2/wk | 3–4/wk | ≥5/wk | ||
| Regular exercise (+) (n = 774) | (n = 439) | (n = 136) | (n = 79) | (n = 80) | |
| BW, kg/year | −0.05 (0.09) | 0.53 (0.21) | 0.67 (0.32) | −0.44 (0.34) | 0.042 |
| WC, cm/year | −0.18 (0.29) | 0.64 (0.29) | 0.69 (0.44) | −0.84 (0.43) | 0.473 |
| Regular exercise (−) (n = 2227) | (n = 1354) | (n = 380) | (n = 274) | (n = 219) | |
| BW, kg/year | 0.48 (0.06) | 0.41 (0.12) | 0.19 (0.17) | 0.17 (0.19) | 0.067 |
| WC, cm/year | 0.53 (0.09) | 0.24 (0.18) | 0.28 (0.22) | 0.09 (0.23) | 0.075 |
BW, body weight; WC, waist circumference. Values are represented as mean (standard error). p for trend were calculated using the Jonckheere-Terpstra test.
Table 6.
Regression analysis between baseline factors and changes in BW, body mass index, or WC.
| Sex- and Age-Adjusted * | Multivariable-Adjusted † | |||||
|---|---|---|---|---|---|---|
| β | (95% CI) | p-Value | β | (95% CI) | p-Value | |
| Changes in BW, kg/year | ||||||
| Men vs. women | 0.10 | (−0.11, 0.32) | 0.340 | 0.36 | (0.07, 0.64) | 0.015 |
| Age, years | −0.17 | (−0.26, −0.09) | <0.001 | −0.16 | (−0.25, −0.08) | <0.001 |
| Baseline BW, kg | 0.00 | (−0.01, 0.00) | 0.157 | −0.01 | (−0.02, −0.01) | <0.001 |
| Baseline body mass index, kg/m2 | −0.01 | (−0.02, 0.00) | 0.016 | −0.01 | (−0.02, 0.00) | 0.012 |
| Regular exercise | −0.31 | (−0.51, −0.11) | 0.002 | −0.20 | (−0.39, −0.02) | 0.032 |
| Lipid-related FOSHU beverage intake | −0.07 | (−0.15, 0.01) | 0.097 | 0.01 | (−0.06, 0.08) | 0.760 |
| Changes in WC, cm/year | ||||||
| Men vs. women | 0.20 | (−0.16, 0.57) | 0.277 | 1.21 | (0.79, 1.63) | <0.001 |
| Age, years | 0.07 | (−0.37, −0.08) | 0.003 | −0.01 | (−0.17, 0.13) | 0.823 |
| Baseline WC, cm | −0.07 | (−0.08, −0.06) | <0.001 | −0.16 | (−0.18, −0.14) | <0.001 |
| Baseline body mass index, kg/m2 | −0.02 | (−0.03, −0.01) | <0.001 | 0.1 | (0.08, 0.12) | <0.001 |
| Regular exercise | −0.46 | (−0.80, −0.12) | 0.008 | 0.02 | (−0.56, 0.06) | 0.117 |
| Lipid-related FOSHU beverage intake | −0.08 | (−0.22, 0.07) | 0.287 | −0.04 | (−0.20, 0.02) | 0.116 |
* Sex was age-adjusted and age was sex-adjusted. † Adjusted for sex, age, baseline BW, body mass index, or WC, regular exercise, and lipid-related specified health beverage intake. BW, body weight; CI, confidence interval; FOSHU, food for specified health uses; WC, waist circumference.
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MDPI and ACS Style
Ide, K.; Takeuchi, M.; Seki, T.; Kawakami, K. Effect of Regular Exercise and Functional Beverages on Changes in Body Weight and Waist Circumference in Healthy Japanese Subjects. Medicina 2018, 54, 64. https://doi.org/10.3390/medicina54040064
AMA Style
Ide K, Takeuchi M, Seki T, Kawakami K. Effect of Regular Exercise and Functional Beverages on Changes in Body Weight and Waist Circumference in Healthy Japanese Subjects. Medicina. 2018; 54(4):64. https://doi.org/10.3390/medicina54040064
Chicago/Turabian StyleIde, Kazuki, Masato Takeuchi, Tomotsugu Seki, and Koji Kawakami. 2018. "Effect of Regular Exercise and Functional Beverages on Changes in Body Weight and Waist Circumference in Healthy Japanese Subjects" Medicina 54, no. 4: 64. https://doi.org/10.3390/medicina54040064
