Prevention of Pathological Fracture of the Proximal Femur: A Systematic Review of Surgical and Percutaneous Image-Guided Techniques Used in Interventional Oncology
Abstract
:1. Introduction
2. Materials and Methods
2.1. Search Strategy and Selection Criteria
2.2. Data Extraction and Quality Assessment
2.3. Systematic Review and Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Ref | Study | NOS stars (out of 9) | Medical Device | Cement | Number of Patients | % Man | Mean Age | Mean Follow-up | % Fracture | % AEs | % SAEs |
---|---|---|---|---|---|---|---|---|---|---|---|
[15] | Cornelis 2017 | 6 | Implant | Yes | 10 | 67 | 62 | 0.65 | 10 | 10 | NK |
[16] | Shemesh 2014 | 6 | Nail | No | 19 | 38.1 | 62 | 0.8 | 0 | 5.3 | NK |
[17] | Alvi 2013 | 6 | Nail | No | 53 | 42 | 60 | 0.9 | 9.4 | 18.9 | 9.4 |
[18] | Moholkar 2004 | 6 | Nail | No | 42 | 28.6 | 66 | 1.1 | 2.4 | 19 | 9.5 |
[19] | Edwards 2001 | 6 | Nail | No | 25 | 44 | 68 | 1.5 | 0 | 8 | 8 |
[20] | Voggenreiter 1996 | 6 | Nail | Yes | 9 | 22 | 59 | 0.7 | 11.1 | 0 | 22.2 |
[21] | Weikert 1991 | 6 | Nail | No | 10 | NK | 67 | 0.7 | 0 | 20 | NK |
[11] | Cazzato 2017 | 5 | Screw | Yes | 11 | 54.5 | 63.7 | 0.17 | 0 | 9.1 | 0 |
[22] | Deschamps 2012 | 6 | Screw | Yes | 12 | 25 | 55 | 0.64 | 0 | 16.7 | 0 |
[6] | Kelekis 2016 | 6 | Needles | Yes | 12 | 83 | NK | 1.35 | 0 | 25 | 0 |
[23] | Tian 2015 | 8 | Needles | Yes | 19 | 47.4 | 58.5 | 0.75 | 0 | 17.5 | 12.5 |
[8] | Mavrovi 2017 | 6 | Screw | Yes | 12 | 75 | 56 | 1.05 | 0 | 8.3 | 0 |
Endpoints | OR * (95% CI) | p Value |
---|---|---|
Fracture | ||
% male | 0.96 (0.89;1.04) | 0.32 |
Mean Age | 1.02 (0.76;1.37) | 0.91 |
Nail | 1.67 (0.15;18.9) | 0.68 |
Cement | 0.60 (0.05;6.79) | 0.68 |
Nb patients | 1.08 (0.97;1.21) | 0.16 |
Adverse Event | ||
% male | 0.98 (0.92;1.05) | 0.59 |
Mean Age | 1.12 (0.83;1.52) | 0.46 |
Nail | 5.33 (0.38;75.8) | 0.22 |
Cement | 0.19 (0.01;2.66) | 0.22 |
Nb patients | 1.17 (0.90;1.55) | 0.24 |
Severe Adverse Event | ||
% male | 0.93 (0.85;1.02) | 0.13 |
Mean Age | 1.08 (0.81;1.45) | 0.59 |
Nail | 3.75 (0.33;42.5) | 0.29 |
Cement | 0.27 (0.02;3.02) | 0.29 |
Nb patients | 1.25 (0.93;1.69) | 0.14 |
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Rodrigues, L.; Cornelis, F.H.; Reina, N.; Chevret, S. Prevention of Pathological Fracture of the Proximal Femur: A Systematic Review of Surgical and Percutaneous Image-Guided Techniques Used in Interventional Oncology. Medicina 2019, 55, 755. https://doi.org/10.3390/medicina55120755
Rodrigues L, Cornelis FH, Reina N, Chevret S. Prevention of Pathological Fracture of the Proximal Femur: A Systematic Review of Surgical and Percutaneous Image-Guided Techniques Used in Interventional Oncology. Medicina. 2019; 55(12):755. https://doi.org/10.3390/medicina55120755
Chicago/Turabian StyleRodrigues, Laëtitia, François H. Cornelis, Nicolas Reina, and Sylvie Chevret. 2019. "Prevention of Pathological Fracture of the Proximal Femur: A Systematic Review of Surgical and Percutaneous Image-Guided Techniques Used in Interventional Oncology" Medicina 55, no. 12: 755. https://doi.org/10.3390/medicina55120755