A Systematic Review of the Role of Prebiotics and Probiotics in Autism Spectrum Disorders
Abstract
:1. Introduction
2. Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Author, Year | Study Design | Sample Size (N) | Study Population | Prebiotic or Probiotics Strains | Study Duration | Key Findings |
---|---|---|---|---|---|---|
Prebiotics | ||||||
Grimaldi 2018 [23] | Randomized, double-blind, placebo-controlled | 41 | 4–11 year old children with ASD, 75% male, UK | Maltodextrin— GLUCIDEX®; 1.8 g | 6 weeks |
|
Sanctuary 2019 [24] | Randomized, double-blind, cross over study | 8 | 2–11 year old children with ASD, 87.5% male, US | Bovine colostrum product (BCP) Bifidobacterium longum supbsp. infantis (UCD272) | Once daily for 12 weeks |
|
Probiotics | ||||||
Kaluzna-Czaplinska 2012 [25] | Prospective, open-label | 22 | 4–10 year old children with ASD, 90% male, Poland | Lactobacillus acidophilus | Twice daily for 1 month |
|
Parracho 2010 [26] | Randomized, double-blind, placebo-controlled | 39 | 4–16 year old children with ASD, UK | Lactobacillus plantarum | 3 weeks |
|
Shaaban 2018 [27] | Prospective, open-label | 30 | 5–9 year old children with ASD, 63% male, Egypt | Lactobacillus acidophilus, Lactobacillus rhamnosus, Bifidobacteria longum | Once daily for 3 months |
|
Slykerman 2018 [28] | Two-center, randomized, double-blind, placebo-controlled | 342 | Children followed from birth to 11 years, New Zealand | Lactobacillus rhamnosus, Bifidobacteria animalis, Bifidobacterium lactis HN019 | Mothers given probiotics from 35 weeks pregnant until 6 months. Children receive treatment from birth to 2 years |
|
Tomova 2015 [12] | Prospective, open-label, controlled | 29 | Children with ASD from 2–9 years old, siblings of ASD children 5–17 years old, control children 2–11 years old, Slovakia | 3 strains of Lactobacillus, 2 strains of Bifidobacteria, 1 strain of Streptococcus | 3 times daily for 4 months |
|
West 2013 [29] | Prospective, open-label | 33 | 3–16 year old children with ASD, USA | Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus delbrueckii, Bifidobacteria longum, Bifidobacteria bifidum | 3 times daily for 21 days |
|
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Ng, Q.X.; Loke, W.; Venkatanarayanan, N.; Lim, D.Y.; Soh, A.Y.S.; Yeo, W.S. A Systematic Review of the Role of Prebiotics and Probiotics in Autism Spectrum Disorders. Medicina 2019, 55, 129. https://doi.org/10.3390/medicina55050129
Ng QX, Loke W, Venkatanarayanan N, Lim DY, Soh AYS, Yeo WS. A Systematic Review of the Role of Prebiotics and Probiotics in Autism Spectrum Disorders. Medicina. 2019; 55(5):129. https://doi.org/10.3390/medicina55050129
Chicago/Turabian StyleNg, Qin Xiang, Wayren Loke, Nandini Venkatanarayanan, Donovan Yutong Lim, Alex Yu Sen Soh, and Wee Song Yeo. 2019. "A Systematic Review of the Role of Prebiotics and Probiotics in Autism Spectrum Disorders" Medicina 55, no. 5: 129. https://doi.org/10.3390/medicina55050129