Association of NOTCH3 Gene Polymorphisms with Ischemic Stroke and Its Subtypes: A Meta-Analysis
Abstract
:1. Introduction
2. Methods
2.1. Search Strategy
2.2. Study Selection
2.3. Data Extraction and Quality Assessment
2.4. Statistical Analysis
3. Results
3.1. Studies Selection and Characteristics
3.2. Quantitative Synthesis and Subgroup Analysis
3.3. Heterogeneity and Publication Bias
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Total Number | Mean Age (Years) | Male | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Author | Year | Country | Ethnicity | Case | Control | Matching | Case | Control | Case | Control | Source of Controls | Clinical Diagnosis | Neuroimaging Method | Genotyping Method | SNP(s) | NOS |
Ghoreishizadeh, A. [25] | 2018 | Iran | A | 65 | 65 | - | 52 ± 14.3 | 54 ± 11.7 | 0.51 | 0.57 | HB | - | - | PCR-SSCP | rs3815188 | 6 |
Ito, D. [14] | 2002 | Japan | A | 235 | 315 | A&S | <71 | - | - | - | HB | - | CT/MRI | PCR-RFLP | rs1044009 | 8 |
Li, Y. [24] | 2013 | China | A | 276 | 118 | - | 68.9 ± 10.9 | 58.9 ± 10.2 | 0.5 | 0.5 | HB | - | CT/MRI | PCR-sequencing | rs3815188, rs1043994 | 6 |
Liu, J. [22] | 2009 | China | A | 1823 | 1832 | A&D | 60.3 ± 9.4 | 59.6 ± 8.8 | 0.6 | 0.6 | HB | - | CT/MRI | PCR-RFLP | rs1044009 §, rs3815188 §, rs1043994 § | 7 |
Mizuno, T. [13] | 2002 | Japan | A | 111 | 23 | - | 70.4 ± 10.9 * | 64.7 ± 11.6 | 0.5 * | 0.5 | - | - | MRI/MRA | PCR-dHPLC | rs3815188 §, rs1043994 | 6 |
Ross, O. [15] | 2013a | USA | C | 452 | 350 | - | - | - | - | - | - | - | CT/MRI | Taqman assay | rs1044009, rs3815188, rs1043994 | 7 |
Ross, O. [15] | 2013b | USA | African | 167 | 131 | - | - | - | - | - | - | - | CT/MRI | Taqman assay | rs1044009, rs3815188, rs1043994 | 7 |
Wang, T. [20] | 2000 | UK | C | 70 | 117 | A&S | 68.8 ± 13.6 | 60.1 ± 15.0 | 0.6 | 0.4 | - | - | Radiological | PCR-RFLP | rs3815188, rs1043994 | 7 |
Xu, Y. [21] | 2015 | China | A | 445 | 200 | A&S | 64.2 ± 12.2 | 62.6 ± 12.1 | 0.6 | 0.6 | HB | - | CT/MRI | PCR-RFLP | rs3815188 | 8 |
Yuan, X. [12] | 2016 | China | A | 134 | 115 | A&S | 59.3 ± 9.0 | 61.5 ± 10.2 | 0.6 | 0.6 | HB, PB | - | - | PCR-sequencing | rs3815188 | 7 |
Zhu, C. [23] | 2016 | China | A | 260 | 600 | - | 64.9 ± 11.7 | 41.4 ± 6.9 **, 66.1 ± 4.2 *** | 0.7 | 0.7 | HB | Specialist | MRI | PCR-sequencing | rs1044009 § | 6 |
Models | ||||
---|---|---|---|---|
Dominant | Recessive | Over-Dominant | Allelic | |
rs1043994 | 1.09 [0.93–1.28], 0.31 | 1.08 [0.67–1.75], 0.74 | 0.90 [0.76–1.07], 0.23 | 0.96 [0.83–1.10], 0.54 |
I2 = 0%; 0.96 | I2 = 0%; 0.57 | I2 = 0%; 0.89 | I2 = 0%; 0.89 | |
rs1044009 | 0.94 [0.84–1.06], 0.32 | 1.16 [0.97–1.38], 0.10 | 1.00 [0.88–1.12], 0.96 | 1.12 [0.98–1.17], 0.11 |
I2 = 0%; 0.66 | I2 = 33%; 0.20 | I2 = 30%; 0.22 | I2 = 0%; 0.80 | |
rs3815188 | 0.89 [0.70–1.14], 0.36 * | 1.07 [0.93–1.23], 0.35 | 1.03 [0.92–1.16], 0.57 | 1.10 [0.93–1.30], 0.25 * |
I2 = 59% p = 0.02 | I2 = 18%, 0.29 | I2 = 42%, 0.10 | I2 = 52% p = 0.03 |
Models | ||||
---|---|---|---|---|
Dominant | Recessive | Over-Dominant | Allelic | |
rs1043994 | 1.17 [0.90–1.51], 0.24 | 1.48 [0.74–2.96], 0.27 | 0.79 [0.60–1.04], 0.09 | 0.92 [0.73–1.17], 0.50 |
I2 = 0%; 0.88 | I2 = 0%; 0.84 | I2 = 0%; 0.82 | I2 = 0%; 0.81 | |
rs3815188 | 1.04 [0.64–1.67], 0.89 * | 1.04 [0.86–1.26], 0.66 | 0.95 [0.80–1.13], 0.55 | 1.05 [0.76–1.45], 0.77 * |
I2 = 71%; 0.02 | I2 = 35%; 0.20 | I2 = 42%; 0.16 | I2 = 70%; 0.02 |
Models | ||||
---|---|---|---|---|
Dominant | Recessive | Over-Dominant | Allelic | |
rs3815188 | 1.06 [0.69–1.63], 0.80 * | 1.08 [0.91–1.28], 0.39 | 0.93 [0.66–1.32], 0.89 * | 1.06 [0.95–1.18], 0.31 |
I2 = 63%; 0.07 | I2 = 0%; 0.75 | I2 = 53%; 0.12 | I2 = 28%; 0.25 |
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Keat Wei, L.; R. Griffiths, L.; Looi, I.; Wee Kooi, C. Association of NOTCH3 Gene Polymorphisms with Ischemic Stroke and Its Subtypes: A Meta-Analysis. Medicina 2019, 55, 351. https://doi.org/10.3390/medicina55070351
Keat Wei L, R. Griffiths L, Looi I, Wee Kooi C. Association of NOTCH3 Gene Polymorphisms with Ischemic Stroke and Its Subtypes: A Meta-Analysis. Medicina. 2019; 55(7):351. https://doi.org/10.3390/medicina55070351
Chicago/Turabian StyleKeat Wei, Loo, Lyn R. Griffiths, Irene Looi, and Cheah Wee Kooi. 2019. "Association of NOTCH3 Gene Polymorphisms with Ischemic Stroke and Its Subtypes: A Meta-Analysis" Medicina 55, no. 7: 351. https://doi.org/10.3390/medicina55070351