Relationship between Serum Uric Acid Levels and Nonalcoholic Fatty Liver Disease in Non-Obese Patients

Round 1

Reviewer 1 Report

In the present study the authors analyze the relationship between uric acid and NAFLD of non-obese and young population. This is an interesting topic because NAFLD is a quite prevalent metabolic alteration. In addition, to investigate about a cheap and easily obtainable predictor is a very useful issue.

Major comments

In lines 27-28, the authors define Nonalcoholic fatty liver disease: “Nonalcoholic fatty liver disease (NAFLD) is defined as a condition with hepatic cells containing fatty deposits without history of alcohol consumption”. The amount of fatty deposits needed to consider that NAFLD is present should be included in this definition.

In lines 31-32, insulin resistance should be included in the list of risk factors.

The introduction is too short. It should be extended.

No information concerning how biochemical parameters were evaluated has been included in the Material and Methods section.

Concerning BMI, three data are provided in the text (lines 84-85), but only two experimental groups are presented in Table 1. It seems that the value 32,27 ± 8,85 is wrong.

Please revise “uric acid” writing throughout the text.

In English 34,24 is wrong; it should be written as 34.24. This should be modified throughout the manuscript.

Do the authors consider that the fact that BMI shows overweight in NAFLD group and normal weight in the control group can be a limitation of the study? Please discuss.

The authors should describe more precisely and extensively the new information provided by this study. Otherwise its novelty is not evident.

There are important English writing mistakes. The text should be revised.

Minor comments

It is not necessary to repeat in the text the P values presented in Table 1.

Please use the same type of writing in all tables.

Author Response

Dear Reviewer

Thank you for your comments and suggestions.

 Corrections are given in the appendix. It also was edited in English by MDPI.

Sincerely,

Dr. Alihan Oral

Reviewer 2 Report

The authors showed a Relation Between Serum Uric Acid Levels And The Degree Of Hepatic Steatosis In Non-Obese Patients. The manuscript is well structured and tha data are interesting.

I have only two minor consideration:

- In the title: I prefer describe non alcoholic fatty liver disease and not hepatic steatosis.

- In the Introduction: NAFLD is considered the expression of multi-metabolic disorders and viceversa. Please consider this study (PMID: 31010049) and comment this in the Introduction.

Author Response

Dear Reviewer

Thank you for your comments and suggestions.

 Corrections are given in the appendix. It also was edited in English by MDPI.

Sincerely,

Dr. Alihan Oral

Round 2

Reviewer 1 Report

The authors have adequately addressed all the comments.