Prospective Clinical Study of Non-Invasive Intracranial Pressure Measurements in Open-Angle Glaucoma Patients and Healthy Subjects
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Group | Identified | Excluded | Included |
---|---|---|---|
NTG | 100 patients: NTG confirmed by a glaucoma specialist. Diurnal IOP lower than 21 mmHg before and during treatment. | Five patients excluded due to a lack of willingness. | 95 patients |
HTG | 100 patients: HTG confirmed by a glaucoma specialist. Diurnal IOP higher than 21 mmHg before and during treatment. | 40 patients excluded: 17 patients did not want to participate in the study; 8 patients changed their telephone number or were not reachable; 9 patients had an artefact in ICP measurement; 4 patients had trabeculectomy; 1 patient underwent cataract surgery; 1 patient died. | 60 patients |
HSs | 65 subjects: age-matched healthy adults with no history of glaucoma or other diseases that could bias the results. | Three subjects had an artefact in ICP measurement. | 62 subjects |
Group | Age (Mean ± SD), Years | Gender, Female, % | Glaucoma Surgery | Glaucoma Medications, N | Systemic Medications, N |
---|---|---|---|---|---|
NTG | 57.52 ± 10.88 | 79 | No | β blockers, 23 Pg analogues, 54 CAIs, 14 α2 agonists, 2 | Diuretics, 8 β blockers, 23 ACE inhibitor, 25 ARBs, 4 Others, 38 |
HTG | 57.47 ± 10.90 | 54 | No | β blockers, 13 Pg analogues, 17 CAIs, 10 α2 agonists, 4 | Diuretics, 8 β blockers, 14 ACE inhibitor, 17 ARBs, 4 Others, 22 |
HS | 57.39 ± 10.62 | 60 | No | β blockers, 0 Pg analogues, 0 CAIs, 0 α2 agonists, 0 | Diuretics, 2 β blockers, 10 ACE inhibitor, 6 ARBs, 1 Others, 14 |
Group | ICP (Mean ± SD) mmHg | 95% CI of the Mean | Med | Min | Max | K–S Test Value | df | p-Value | Skewness (SE) | Kurtosis (SE) |
---|---|---|---|---|---|---|---|---|---|---|
NTG N = 95 | 9.42 ± 2.83 | 8.84–10.00 | 9.25 | 3.21 | 15.79 | 0.05 | 95 | 0.200 | −0.02 (0.25) | −0.63 (0.50) |
HTG N = 60 | 8.11 ± 2.68 | 7.42–8.80 | 8.08 | 3.37 | 15.17 | 0.06 | 60 | 0.200 | 0.49 (0.31) | −0.27 (0.61) |
HSs N = 62 | 10.73 ± 2.16 | 10.18–11.28 | 10.62 | 7.26 | 15.17 | 0.09 | 62 | 0.200 | −0.29 (0.30) | −0.89 (0.60) |
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Deimantavicius, M.; Hamarat, Y.; Lucinskas, P.; Zakelis, R.; Bartusis, L.; Siaudvytyte, L.; Janulevicienė, I.; Ragauskas, A. Prospective Clinical Study of Non-Invasive Intracranial Pressure Measurements in Open-Angle Glaucoma Patients and Healthy Subjects. Medicina 2020, 56, 664. https://doi.org/10.3390/medicina56120664
Deimantavicius M, Hamarat Y, Lucinskas P, Zakelis R, Bartusis L, Siaudvytyte L, Janulevicienė I, Ragauskas A. Prospective Clinical Study of Non-Invasive Intracranial Pressure Measurements in Open-Angle Glaucoma Patients and Healthy Subjects. Medicina. 2020; 56(12):664. https://doi.org/10.3390/medicina56120664
Chicago/Turabian StyleDeimantavicius, Mantas, Yasin Hamarat, Paulius Lucinskas, Rolandas Zakelis, Laimonas Bartusis, Lina Siaudvytyte, Ingrida Janulevicienė, and Arminas Ragauskas. 2020. "Prospective Clinical Study of Non-Invasive Intracranial Pressure Measurements in Open-Angle Glaucoma Patients and Healthy Subjects" Medicina 56, no. 12: 664. https://doi.org/10.3390/medicina56120664