Selected Oxidative Stress Markers in Colorectal Cancer Patients in Relation to Primary Tumor Location—A Preliminary Research
Abstract
:1. Introduction
2. Materials and Methods
2.1. Design, Patients and Samples
2.2. MDA, TOS and TAS Determinations
2.3. Statistical Analysis
3. Results
3.1. Clinical Parameters of the Patients
3.2. Oxidative Stress and Primary Tumor Location
3.3. Oxidative Stress and Clinical Stage of Disease
3.4. Oxidative Stress and Comorbidities
3.5. Oxidative Stress and Age
4. Discussion
5. Conclusions
6. Limitations
Author Contributions
Funding
Conflicts of Interest
Appendix A
Primary Tumor Location | Mean | SD |
---|---|---|
Left-sided colon (n = 30) | 2294.04 | ±1283.00 |
Right-sided colon (n = 13) | 3481.63 | ±1503.26 |
Rectum (n = 23) | 3481.63 | ±1269.15 |
Total (n = 66) | 2478.04 | ±1397.05 |
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Clinical Features | Primary Tumor Location | Total (n = 66) | ||
---|---|---|---|---|
Left-Sided Colon (n = 30) | Right-Sided Colon (n = 13) | Rectum (n = 23) | ||
Female Male | 11 (36.67%) | 7 (53.85%) | 7 (39.43%) | 25 (37.88%) |
19 (63.33%) | 6 (46.15%) | 16 (69.57%) | 41 (62.12%) | |
Age [years] | 68.00 | 69.00 | 66.00 | 65.50 |
(59.00–73.00) | (61.00–74.00) | (57.00–73.00) | (60.00–73.00) | |
BMI [kg/m2] | 25.51 | 27.98 | 26.50 | 26.34 |
(SD ± 4.34) | (SD ± 4.04) | (SD ± 3.86) | (SD ± 4.16) | |
Normal body weight (BMI value: 18.5–24.9) | 16 (53.33%) | 4 (30.77%) | 10 (43.48%) | 30 (45.45%) |
Overweight (BMI value: 25.0–29.9) | 12 (40.00%) | 4 (30.77%) | 7 (30.43%) | 23 (34.85%) |
Obesity (BMI value: ≥30.0) | 2 (6.67%) | 5 (38.46%) | 6 (26.09%) | 13 (19.70%) |
CVD 1—Yes | 19 (63.33%) | 7 (53.85%) | 12 (52.17%) | 38 (57.58%) |
CVD—No | 11 (36.67%) | 6 (46.15%) | 11 (47.83%) | 28 (42.42%) |
T2DM 2—Yes | 3 (10.00%) | 1 (7.69%) | 4 (17.39%) | 8 (12.12%) |
T2DM—No | 27 (90.00%) | 12 (92.31%) | 19 (82.61%) | 58 (87.88%) |
CS 3 I | 0 (0.00%) | 0 (0.00%) | 4 (17.39%) | 4 (6.06%) |
CS II | 7 (23.34%) | 3 (23.08%) | 5 (21.74%) | 15 (22.73%) |
CS III | 13 (43.33%) | 3 (23.08%) | 6 (26.09%) | 22 (33.33%) |
CS IV | 10 (33.33%) | 7 (53.84%) | 8 (34.78%) | 25 (37.88%) |
Gx | 4 (13.33%) | 1 (7.69%) | 6 (26.09%) | 11 (16.66%) |
G1 | 4 (13.33%) | 1 (7.69%) | 3 (13.04%) | 8 (12.12%) |
G2 | 18 (60.01%) | 7 (53.85%) | 13 (56.52%) | 38 (57.58%) |
G3 | 4 (13.33%) | 4 (30.77%) | 1 (4.35%) | 9 (13.64%) |
Primary Tumor Location | TOS [µmol/L] | p | TAS [µmol/L] | p | MDA [ng/mL] | p |
---|---|---|---|---|---|---|
Left-sided colon (n = 30) | 827.66 (SD ± 443.80) | 0.790 | 257.60 (235.60–294.23) | 0.888 | 2294.04 (SD ± 1283.00) | 0.026 |
Right-sided colon (n = 13) | 842.78 (SD ± 323.54) | 278.76 (231.59–337.10) | 3481.63 (SD ± 1503.26) | |||
Rectum (n = 23) | 767.75 (SD ± 368.58) | 269.06 (236.13–278.47) | 2150.80 (SD ± 1269.15) | |||
Total (n = 66) | 809.76 (SD ± 392.65) | - | 253.19 (233.33–310.66) | - | 2478.04 (SD ± 1397.05) | - |
TNM Classification | TOS [µmol/L] | p | TAS [µmol/L] | p | MDA [ng/mL] | p |
---|---|---|---|---|---|---|
CS 1 I and II (n = 19) | 694.32 (SD ± 407.92) | 0.310 | 268.99 (234.26–362.35) | 0.539 | 2541.23 (SD ± 1722.50) | 0.552 |
CS III (n = 22) | 829.62 (SD ± 403.33) | 251.16 (233.53–272.46) | 2239.99 (SD ± 995.50) | |||
CS IV (n = 25) | 880.02 (SD ± 366.54) | 251.49 (235.60–290.49) | 2639.50 (SD ± 1453.03) | |||
Total (n = 66) | 809.76 (SD ± 392.65) | - | 253.19 (233.33–310.66) | - | 2478.04 (SD ± 1397.05) | - |
Comorbidities | TOS (µmol/L) | p | TAS (µmol/L) | p | MDA (ng/mL) | p | |
---|---|---|---|---|---|---|---|
CVD 1 | No (n = 28) | 708.11 (SD ± 429.69) | 0.07 | 256.57 (225.85–300.58) | 0.500 | 2223.42 (SD ± 1246.08) | 0.21 |
Yes (n = 38) | 884.67 (SD ± 350.03) | 253.20 (237.20–318.27) | 2665.65 (SD ± 1486.76) | ||||
T2DM 2 | No (n = 58) | 802.56 (SD ± 396.85) | 0.69 | 251.49 (233.33–294.23) | 0.596 | 2345.16 (SD ± 1359.78) | 0.04 |
Yes (n = 8) | 861.97 (SD ± 381.57) | 264.51 (235.73–355.54) | 3441.44 (SD ± 1363.84) | ||||
Obesity | No (n = 53) | 810.59 (SD ± 400.75) | 0.97 | 254.90 (232.53–294.23) | 0.420 | 2332.07 (SD ± 1394.99) | 0.09 |
Yes (n = 13) | 806.39 (SD ± 373.02) | 251.49 (247.22–310.66) | 3073.17 (SD ± 1288.99) | ||||
Total (n = 66) | 809.76 (SD ± 392.65) | - | 253.19 (233.33–310.66) | - | 2478.04 (SD ± 1397.05) | - |
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Janion, K.; Szczepańska, E.; Nowakowska-Zajdel, E.; Strzelczyk, J.; Copija, A. Selected Oxidative Stress Markers in Colorectal Cancer Patients in Relation to Primary Tumor Location—A Preliminary Research. Medicina 2020, 56, 47. https://doi.org/10.3390/medicina56020047
Janion K, Szczepańska E, Nowakowska-Zajdel E, Strzelczyk J, Copija A. Selected Oxidative Stress Markers in Colorectal Cancer Patients in Relation to Primary Tumor Location—A Preliminary Research. Medicina. 2020; 56(2):47. https://doi.org/10.3390/medicina56020047
Chicago/Turabian StyleJanion, Karolina, Elżbieta Szczepańska, Ewa Nowakowska-Zajdel, Joanna Strzelczyk, and Angelika Copija. 2020. "Selected Oxidative Stress Markers in Colorectal Cancer Patients in Relation to Primary Tumor Location—A Preliminary Research" Medicina 56, no. 2: 47. https://doi.org/10.3390/medicina56020047