Immunohistochemical Femoral Nerve Study Following Bisphosphonates Administration
Abstract
:1. Introduction
1.1. Femoral Nerve
1.1.1. Anatomy and Physiology of the Femoral Nerve
1.1.2. Femoral Nerve Damage
1.2. Bisphosphonates
1.2.1. BP Chemistry
1.2.2. BP Pharmacodynamics
1.2.3. BP Distribution
1.2.4. BP Mechanism of Action
1.2.5. BP Adverse and Side Effects
1.2.5.1. Short-Term Side Effects
1.2.5.2. Long-Term Side Effects
Osteonecrosis of the Jaw (ONJ)
Atrial Fibrillation
Bone Turnover Suppression and Atypical Femoral Fractures (AFFs)
2. Materials and Methods
2.1. Animals
2.2. Dose
2.3. Hematoxylin-Eosin staining
2.4. Immunohistochemistry
2.5. Immunohistochemical Markers
2.5.1. NeuN
2.5.2. Sox10
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Karakousis, V.A.; Liouliou, D.; Loula, A.; Kagianni, N.; Dietrich, E.-M.; Meditskou, S.; Sioga, A.; Papamitsou, T. Immunohistochemical Femoral Nerve Study Following Bisphosphonates Administration. Medicina 2020, 56, 140. https://doi.org/10.3390/medicina56030140
Karakousis VA, Liouliou D, Loula A, Kagianni N, Dietrich E-M, Meditskou S, Sioga A, Papamitsou T. Immunohistochemical Femoral Nerve Study Following Bisphosphonates Administration. Medicina. 2020; 56(3):140. https://doi.org/10.3390/medicina56030140
Chicago/Turabian StyleKarakousis, Vasileios Alexandros, Danai Liouliou, Aikaterini Loula, Nikoleta Kagianni, Eva-Maria Dietrich, Soultana Meditskou, Antonia Sioga, and Theodora Papamitsou. 2020. "Immunohistochemical Femoral Nerve Study Following Bisphosphonates Administration" Medicina 56, no. 3: 140. https://doi.org/10.3390/medicina56030140