The Effectiveness of Low-dose Dexmedetomidine Infusion in Sedative Flexible Bronchoscopy: A Retrospective Analysis
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Group D (n = 35) | Group M (n = 33) | p Value | |
---|---|---|---|
Gender (M:F) | 16:19 | 15:18 | 0.98 |
Age (year) | 62.6 ± 12.9 | 63.6 ± 15.6 | 0.75 |
Weight (kg) | 63.0 ± 13.2 | 57.4 ± 11.7 | 0.08 |
Height (cm) | 161.9 ± 7.9 | 160.1 ± 8.7 | 0.38 |
ASA class I/II/III (n) 1 | 2000/12/23 | 2001/8/24 | 0.34 |
Cancer, n(%) | 12 (34.2) | 9 (27.3) | 0.53 |
Baseline oxygenation (%) | 96.8 ± 1.6 | 97.1 ± 2.8 | 0.61 |
Baseline heart rate (beats/min) | 80.4 ± 11.5 | 80.3 ± 15.3 | 0.98 |
Baseline systolic blood pressure (mmHg) | 148.9 ± 21.4 | 143.6 ± 24.1 | 0.34 |
Bronchoscopy examination/biopsy (n) | 20/15 | 18/15 | 0.83 |
Sedation time (min) | 29.2 ± 12.5 | 21.8 ± 10.3 | 0.02 * |
Procedure time (min) | 21.1 ± 11.0 | 18.4 ± 9.9 | 0.35 |
Group D (n = 35) | Group M (n = 33) | p Value | |
---|---|---|---|
Propofol dose (mg) | 147.4 ± 66.1 | 165.6 ± 88.3 | 0.37 |
Fentanyl dose (μg) | 44.8 ± 14.8 | 46.9 ± 20.6 | 0.56 |
Dexmedetomidine (μg) | 47.3 ± 16.1 | 0 | NA |
Midazolam dose (mg) | 0 | 1.3 ± 0.8 | NA |
Procedural interruption by cough or movement, n(%) | 1 (3.3) | 12 (36.3) | <0.001 * |
Bronchoscopist satisfaction 1 (n) 1/2/3/4 | 0/0/15/20 | 0/2/23/8 | 0.01 * |
Transient hypoxemia, n(%) | 8 (22.9) | 6 (18.2) | 0.63 |
Airway management | |||
Jaw lift, n(%) | 7 (20) | 8 (24.2) | 0.67 |
Mask, n(%) | 0 (0) | 1 (3.0) | 0.29 |
Intubation, n(%) | 0 (0) | 0 (0) | NA |
Hypotension, n(%) | 12 (33.3) | 8 (24.2) | 0.36 |
Bradycardia, n(%) | 7 (20) | 2 (6.1) | 0.03 * |
Group D (n = 35) | Group M (n = 33) | p Value | |
---|---|---|---|
Awake time (min) | 6.4 ± 4.4 | 5.5 ± 4.5 | 0.14 |
Ambulation time (min) | 24.9 ± 9.7 | 31.5 ± 11.9 | 0.016 * |
Adverse events | |||
Nausea/vomiting, n(%) | 4 (11.4) | 1 (3.0) | 0.18 |
Dizziness, n(%) | 5 (14.2) | 1 (3.0) | 0.1 |
Recall, n(%) | 0 (0) | 0 (0) | NA |
Pain, n(%) | 1 (2.9) | 0 (0) | 0.33 |
Patient satisfaction 1 (n) 1/2/3/4 | 0/0/29/6 | 0/0/26/7 | 0.91 |
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Wu, S.H.; Lu, D.V.; Hsu, C.D.; Lu, I.C. The Effectiveness of Low-dose Dexmedetomidine Infusion in Sedative Flexible Bronchoscopy: A Retrospective Analysis. Medicina 2020, 56, 193. https://doi.org/10.3390/medicina56040193
Wu SH, Lu DV, Hsu CD, Lu IC. The Effectiveness of Low-dose Dexmedetomidine Infusion in Sedative Flexible Bronchoscopy: A Retrospective Analysis. Medicina. 2020; 56(4):193. https://doi.org/10.3390/medicina56040193
Chicago/Turabian StyleWu, Sheng Hua, David Vi Lu, Chun Dan Hsu, and I Cheng Lu. 2020. "The Effectiveness of Low-dose Dexmedetomidine Infusion in Sedative Flexible Bronchoscopy: A Retrospective Analysis" Medicina 56, no. 4: 193. https://doi.org/10.3390/medicina56040193