Incidence of Severe Chronic Neutropenia in South Korea and Related Clinical Manifestations: A National Health Insurance Database Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Sources of Data and Data Selection
2.2. Estimation of the Incidence of SCN and Associated Clinical Features
2.3. Statistics
3. Results
3.1. Annual Incidence of SCN in Korea in 2011–2015
3.2. Clinical Features and Associated Infectious Complications
3.3. Hematologic Evolution to Acute Leukemia and/or MDS and Mortality
4. Discussion and Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Total Population | New Cases | F/M Ratio of Cases | Incidence Rate per 100,000 | |||||||
---|---|---|---|---|---|---|---|---|---|---|
All | Male | Female | All | Male | Female | All | Male | Female | ||
2011 | 49,779,440 | 24,942,339 | 24,837,101 | 63 | 29 | 34 | 1.17 | 0.13 | 0.12 | 0.14 |
2012 | 50,004,441 | 25,039,557 | 24,964,884 | 81 | 36 | 45 | 1.25 | 0.16 | 0.14 | 0.18 |
2013 | 50,219,669 | 25,132,612 | 25,087,057 | 85 | 27 | 58 | 2.15 | 0.17 | 0.11 | 0.23 |
2014 | 50,423,955 | 2,5219,810 | 25,204,145 | 78 | 36 | 42 | 1.17 | 0.15 | 0.14 | 0.17 |
2015 | 51,014,947 | 25,585,894 | 25,429,053 | 60 | 23 | 37 | 1.61 | 0.12 | 0.09 | 0.15 |
Age Group (Years) | Cases | Average Incidence Rate per 100,000 | F/M Incidence Rate Relative Risk (95% CI) | ||||
---|---|---|---|---|---|---|---|
All | Male | Female | All | Male | Female | ||
0–9 | 156 | 79 | 77 | 1.36 | 1.33 | 1.38 | 1.03 (0.76–1.42) |
10–19 | 13 | 6 | 7 | 0.08 | 0.07 | 0.08 | 1.28 (0.43–3.83) |
20–29 | 18 | 4 | 14 | 0.11 | 0.04 | 0.18 | 3.85 (1.27–11.69) |
30–39 | 23 | 5 | 18 | 0.11 | 0.05 | 0.18 | 3.75 (1.39–10.10) |
40–49 | 27 | 12 | 15 | 0.12 | 0.10 | 0.14 | 1.30 (0.61–2.77) |
50–59 | 60 | 17 | 43 | 0.31 | 0.17 | 0.44 | 2.56 (1.46–4.49) |
60–69 | 31 | 7 | 24 | 0.29 | 0.15 | 0.41 | 3.20 (1.38–7.43) |
70–79 | 30 | 15 | 15 | 0.38 | 0.46 | 0.32 | 0.73 (0.36–1.50) |
>80 | 9 | 6 | 3 | 0.39 | 1.14 | 0.12 | 0.21 (0.05–0.85) |
Total | 367 | 151 | 216 | 0.14 | 0.12 | 0.17 | 1.43 (1.16–1.76) |
Age Group (Years) | Leukemia/MDS Cases | ||
---|---|---|---|
Cases | Progression OR (95% CI) | p Value | |
10–14 | 1 | 10.46 (0.18–142.68) | 0.125 |
25–29 | 1 | 2.59 (0.06–20.76) | 0.356 |
40–44 | 1 | 3.47 (0.07–29.39) | 0.286 |
45–49 | 3 | 8.01 (1.26–37.13) | 0.014 |
50–54 | 1 | 1.03 (0.02–7.50) | >0.999 |
55–59 | 2 | 2.33 (0.24–11.74) | 0.256 |
65–69 | 1 | 1.80 (0.04–13.83) | 0.458 |
70–74 | 2 | 3.52 (0.35–18.31) | 0.146 |
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Lee, N.; Lee, B.C. Incidence of Severe Chronic Neutropenia in South Korea and Related Clinical Manifestations: A National Health Insurance Database Study. Medicina 2020, 56, 262. https://doi.org/10.3390/medicina56060262
Lee N, Lee BC. Incidence of Severe Chronic Neutropenia in South Korea and Related Clinical Manifestations: A National Health Insurance Database Study. Medicina. 2020; 56(6):262. https://doi.org/10.3390/medicina56060262
Chicago/Turabian StyleLee, Nuri, and Boung Chul Lee. 2020. "Incidence of Severe Chronic Neutropenia in South Korea and Related Clinical Manifestations: A National Health Insurance Database Study" Medicina 56, no. 6: 262. https://doi.org/10.3390/medicina56060262