Burden of Comorbidities in Patients with OSAS and COPD-OSAS Overlap Syndrome
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Polysomnography
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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OSAS Patients n = 163 | Overlap Syndrome Patients n = 163 | p | |
---|---|---|---|
Gender (males/females) | 139/24 | 138/25 | 0.877 |
Age (years) | 59 (51.5–66.5) | 61 (54–68) | 0.221 |
BMI (kg/m2) | 36.1 (32–39.2) | 36.2 (32.1–41) | 0.496 |
Neck circumference (cm) | 45 (42–48) | 45 (42–48) | 0.922 |
Waist circumference (cm) | 122 (110.5–129) | 126 (114–135) | 0.018 |
Hip circumference (cm) | 119 (111–126) | 118 (111–128 | 0.972 |
WHR | 0.86 (0.80–0.96) | 0.89 (0.80–0.96) | 0.377 |
Smoking status | |||
Never smokers (%) | 31.3% | 25.2% | 0.219 |
Current smokers (%) | 63.1% | 61.3% | 0.631 |
Ex-smokers (%) | 36.9% | 38.7% | 0.734 |
OSAS Patients n = 163 | Overlap Syndrome Patients n = 163 | p | |
---|---|---|---|
Recording time (min) | 378 (356–404) | 383 (336–402) | 0.665 |
TST (min) | 306 (248.5–335.5) | 309.8 (253.3–349.6) | 0.152 |
N1 (%) | 18.8 (9–34.5) | 15.6 (7.8–31.9) | 0.308 |
N2 (%) | 59.8 (45.6–72.4) | 60.6 (45.4–73.3) | 0.646 |
N3 (%) | 5.6 (0–14.6) | 6.3 (0.03–12.9) | 0.939 |
REM (%) | 9.6 (3.9–14.5) | 7.6 (2.4–15) | 0.275 |
AHI (events/h) | 35.2 (16.8–62.3) | 36.8 (16–61) | 0.346 |
ODI (events/h) | 46.3 (26.5–63.1) | 45.9 (22.5–69.9) | 0.668 |
Aver SpO2 (%) | 92 (90–93) | 91 (88–93) | 0.008 |
Min SpO2 (%) | 78 (70–83) | 75 (66.3–82) | 0.100 |
T < 90% (min) | 12.1 (3.4–35.9) | 22.3 (4.8–55.1) | 0.020 |
Arousal index | 31.3 (22–45.7) | 27.3 (12–45.2) | 0.110 |
Sleep efficiency (%) | 80.8 (69.2–86.6) | 81.8 (69.2–89.4) | 0.300 |
ESS score | 9 (6–14) | 9 (6–14) | 0.988 |
OSAS Patients n = 163 | Overlap Syndrome Patients n = 163 | p | |
---|---|---|---|
FEV1 (% predicted) | 97.8 (86.8–110) | 68.1 (51.4–79.3) | <0.001 |
FVC (% predicted) | 87.9 (77–100) | 73.3 (57.9–89) | <0.001 |
FEV1/FVC (%) | 85.8 (82.2–90.4) | 67.2 (62.3–69.2) | <0.001 |
Airflow limitation | |||
Mild (%) | - | 24.5% | - |
Moderate (%) | - | 57.7% | - |
Severe (%) | - | 17.8% | - |
pH | 7.42 (7.40–7.44) | 7.42 (7.41–7.44) | 0.827 |
pO2 (mmHg) | 77 (70–83.2) | 71.6 (64–79.5) | <0.001 |
pCO2 (mmHg) | 41 (39–44) | 43 (39–44) | 0.040 |
OSAS Patients n = 163 | Overlap Syndrome Patients n = 163 | p | |
---|---|---|---|
Comorbidities total | 2 (1–2) | 2 (1–3) | 0.033 |
No comorbidities (n, %) | 34 (20.9) | 24 (14.7) | 0.148 |
Hypertension (n, %) | 96 (58.9) | 101 (62) | 0.571 |
Cardiovascular disease (n, %) | 22 (13.5) | 39 (23.9) | 0.016 |
Dementia (n, %) | 1 (0.6) | 1 (0.6) | 1 |
Cerebrovascular disease (n, %) | 2 (1.2) | 2 (1.2) | 1 |
Diabetes (n, %) | 29 (17.8) | 37 (22.7) | 0.270 |
Dyslipidemia (n, %) | 46 (28.2) | 52 (31.9) | 0.469 |
Atrial fibrillation (n, %) | 7 (4.3) | 14 (8.6) | 0.114 |
Cancer (n, %) | 0 (0) | 3 (1.8) | 0.082 |
Depression (n, %) | 10 (6.1) | 7 (4.3) | 0.455 |
Gastroesophageal reflux (n, %) | 7 (4.3) | 6 (3.7) | 0.777 |
Connective tissue disease (n, %) | 3 (1.8) | 6 (3.7) | 0.311 |
Chronic kidney disease (n, %) | 1 (0.6) | 1 (0.6) | 1 |
Liver disease (n, %) | 1 (0.6) | 0 (0) | 0.317 |
Osteoporosis (n, %) | 3 (1.8) | 2 (1.2) | 0.652 |
Hyperuricemia (n, %) | 6 (3.7) | 4 (2.5) | 0.521 |
Thyroid gland disease (n, %) | 13 (8) | 18 (11) | 0.345 |
Parkinson disease (n, %) | 3 (1.8) | 0 (0) | 0.082 |
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Voulgaris, A.; Archontogeorgis, K.; Pataka, A.; Flaris, A.N.; Ntolios, P.; Bonsignore, M.R.; Schiza, S.; Steiropoulos, P. Burden of Comorbidities in Patients with OSAS and COPD-OSAS Overlap Syndrome. Medicina 2021, 57, 1201. https://doi.org/10.3390/medicina57111201
Voulgaris A, Archontogeorgis K, Pataka A, Flaris AN, Ntolios P, Bonsignore MR, Schiza S, Steiropoulos P. Burden of Comorbidities in Patients with OSAS and COPD-OSAS Overlap Syndrome. Medicina. 2021; 57(11):1201. https://doi.org/10.3390/medicina57111201
Chicago/Turabian StyleVoulgaris, Athanasios, Kostas Archontogeorgis, Athanasia Pataka, Alexandros N. Flaris, Paschalis Ntolios, Maria R. Bonsignore, Sophia Schiza, and Paschalis Steiropoulos. 2021. "Burden of Comorbidities in Patients with OSAS and COPD-OSAS Overlap Syndrome" Medicina 57, no. 11: 1201. https://doi.org/10.3390/medicina57111201