The Immunohistochemical Expression of the Serine and Arginine-Rich Splicing Factor 1 (SRSF1) Is a Predictive Factor of the Recurrence of Basal Cell Carcinoma: A Preliminary Study on a Series of 52 Cases
Abstract
:1. Introduction
2. Materials and Methods
2.1. Ethics Statement and Sample Collection
2.2. Immunohistochemistry
3. Results
3.1. Clinicopathologic Features of the BCC Cases from Our Series
3.2. SRSF1’s Immunohistochemical Expression and Its Relationship with the Local Recurrence of BCCs
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Number of Cases | Age Range | Gender | Anatomic Site | Local Recurrence | Histological Subtype | SRSF1 IRS |
---|---|---|---|---|---|---|
52 | 36–84 y | 32 M; 20 F | Arms (n = 21) Legs (n = 15) Face (n = 10) Shoulders (n = 5) Ankles (n = 1) | No (n = 47) Yes (n = 5) | Nodular BCC (n = 27) Superficial BCC (n = 15) Sclerosing/morphoeic BCC (n = 6) Basosquamous carcinoma (n = 4) | L-IRS (n = 34) H-IRS (n = 18) |
Local Recurrence | High SRSF1 IRS | Low SRSF1 IRS |
---|---|---|
No | 14 | 33 |
Yes | 4 | 1 |
Gender | High SRSF1 IRS | Low SRSF1 IRS |
---|---|---|
Female | 6 | 14 |
Male | 12 | 20 |
Anatomic Site | High SRSF1 IRS | Low SRSF1 IRS |
---|---|---|
Ankles | 1 | 0 |
Arms | 4 | 17 |
Face | 5 | 5 |
Legs | 4 | 11 |
Shoulders | 4 | 1 |
Histological Subtype | High SRSF1 IRS | Low SRSF1 IRS |
---|---|---|
Basosquamous | 2 | 2 |
Nodular | 5 | 22 |
Sclerosing/morphoeic | 2 | 4 |
Superficial | 9 | 6 |
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Broggi, G.; Barbagallo, D.; Lacarrubba, F.; Verzì, A.E.; Micali, G.; Purrello, M.; Caltabiano, R. The Immunohistochemical Expression of the Serine and Arginine-Rich Splicing Factor 1 (SRSF1) Is a Predictive Factor of the Recurrence of Basal Cell Carcinoma: A Preliminary Study on a Series of 52 Cases. Medicina 2022, 58, 139. https://doi.org/10.3390/medicina58010139
Broggi G, Barbagallo D, Lacarrubba F, Verzì AE, Micali G, Purrello M, Caltabiano R. The Immunohistochemical Expression of the Serine and Arginine-Rich Splicing Factor 1 (SRSF1) Is a Predictive Factor of the Recurrence of Basal Cell Carcinoma: A Preliminary Study on a Series of 52 Cases. Medicina. 2022; 58(1):139. https://doi.org/10.3390/medicina58010139
Chicago/Turabian StyleBroggi, Giuseppe, Davide Barbagallo, Francesco Lacarrubba, Anna Elisa Verzì, Giuseppe Micali, Michele Purrello, and Rosario Caltabiano. 2022. "The Immunohistochemical Expression of the Serine and Arginine-Rich Splicing Factor 1 (SRSF1) Is a Predictive Factor of the Recurrence of Basal Cell Carcinoma: A Preliminary Study on a Series of 52 Cases" Medicina 58, no. 1: 139. https://doi.org/10.3390/medicina58010139