Aseptic Abscess Syndrome in Rheumatoid Arthritis Patient
Round 1
Reviewer 1 Report
- The topic is of interest but some revisions are needed.
1) The part on genetics should not be included in the introduction and does not add useful information to the rest of the text, at least there.
2) The case presentation is a bit confused. I guess that RA stands for Rheumatoid arthritis and this should be precised. During the presentation of the case, it should be mentioned that the patient was admitted earlier to the Rheumatology department (temporal confusion); the same goes for the description of the Orthopedic problem of the patient, which pops up during the story.
3) Where was the biopsy for the histopathological examination performed?
4) The authors state the patient met SIRS criteria... is SIRS criteria a differential diagnosis? It should be at least briefly stated in the case description
5) the Authors state is uncommon for blood cultures to be positive in sepsis. Considering the non-contiguous distribution of involvement, could an infective endocharditis be suspected? Has the patient undergone an echocardiogram?
6) Considering the important cutaneous manifestations of this case, the differential diagnosis with pyoderma gangrenosum should be discussed
7) Neutrophilic dermatoses are gaining attention from the dermatology community. For example, negativity of the microbiological exams is important in another neutrophilic dermatosis often mistaken for an infectious or neoplastic process, such as erosive pustular dermatosis of the scalp (Michelerio A, Vassallo C, Fiandrino G, Tomasini CF. Erosive Pustular Dermatosis of the Scalp: A Clinicopathologic Study of Fifty Cases. Dermatopathology (Basel). 2021;8(4):450-462.). Other neutrophilic dermatoses should be briefly discussed.
8) What are the other treatments for AAS?
Author Response
The response is in attachment
Author Response File: Author Response.pdf
Reviewer 2 Report
Reviewer comments
Line |
Manuscript |
Comments |
15 |
They may be associated with inflammatory bowel disease and autoimmune diseases |
English editing is needed |
16 |
We would like to present a case |
Not scientific language |
20 |
Despite Covid-29 infection treated with remdesivir |
English editing is required in the whole manuscript Abbreviation capital Meaning should be mentioned at the first appearance of the abbreviation |
22 |
AA is a difficult recognize, so practitioners have to be aware 22 of this condition. |
The conclusion should mention the association with rheumatoid |
23 |
The examination of the patient was conducted according to the Declaration of 23 Helsinki principles. |
It is better to write this sentence under the case presentation section not at the abstract |
37 |
with inflammatory bowel disease |
an inflammatory |
39 |
AAS has many features in common with neutrophilic dermatoses and is currently 39 |
Not appropriate to write a paragraph with only 2 lines |
55 |
We would like to present |
Not scientific writing |
|
Abstract |
The most important here is the association between AAS and RA. However, the authors did not refer to that at the introduction |
58-67 |
|
Re arrange this paragraph as it is confusing |
73 |
extensible surfaces |
Extensive |
79 |
|
The laboratory investigations should be mentioned after this part |
102 |
prednisone 40 mg and pulse with methylprednisolone iv (500 mg every day for 3 102 days) were included in the treatment |
Why both oral and in steroids at the same time |
106 |
adalimumab 80 mg was |
What is the rationale of adding adalimumab after the improvement of the case |
Discussion |
|
Many sentences were written without references |
158 |
|
The authors mentioned many positive antibodies at the discussion and did not mention that at the case presentation The titre of autoantibodies is very high which necessities exclusion of lupus or overlap syndrome |
|
|
The discussion is poor and did not emphasize on the association between rheumatoid and aas |
Author Response
The response is in attachment
Author Response File: Author Response.pdf
Round 2
Reviewer 2 Report
The reply to the reviewer's comment is to some extent strange to the scientific society . The authors wrote I have corrected in front of each comment.
This reply is not satisfying and not scientific . The authors should follow the scientific rules of writing a reply to reviewers.
Author Response
Dear Review,
Thank you for your important suggestions and time devoted to my manuscript. I tried to adjusted my manuscript.
Best regards
Agnieszka Owczarczyk-Saczonek
Author Response File: Author Response.pdf
Round 3
Reviewer 2 Report
accept in the present form