Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Participants
2.2. Laboratory Analyses
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Parameter | Without DF | With DF | p |
---|---|---|---|
N | 19 | 23 | |
Age, years | 59.2 ± 12.9 | 66.74 ± 9.4 | <0.05 |
Gender, male/female, % | 57.9/42.1 | 82.6/17.4 | 0.098 |
BMI, kg/m2 | 31.7 ± 5.7 | 28.7 ± 4.7 | 0.116 |
Diabetes duration, years | 7.1 ± 5.6 | 13.7 ± 7.8 | <0.05 |
Obesity, % | 69.2 | 45.5 | 0.293 |
Hypertension, % | 88.9 | 77.3 | 0.427 |
Smoking, % | 18.8 | 40.9 | 0.178 |
HbA1c, % | 9.6 ± 1.7 | 7.8 ± 1.3 | <0.05 |
Glucose, mmol/L | 10.1 ± 3.7 | 9.7 ± 2.6 | 0.665 |
Therapy | |||
OAD | 43.7 | 30.4 | <0.001 |
OAD + Insulin | 43.8 | 0 | <0.001 |
Insulin | 12.5 | 69.6 | <0.001 |
Parameter | Without DF | With DF | p |
---|---|---|---|
RBC (×1012/L) | 4.74 ± 0.61 | 4.04 ± 0.71 | <0.05 |
Hgb, g/L | 137.3 ± 19.7 | 121.2 ± 10.8 | <0.05 |
WBC (×109/L) | 7.8 ± 1.8 | 8.9 ± 2.5 | 0.123 |
Neutrophils (×109/L) # | 4.0 (3.3–5.3) | 5.6 (4.2–6.6) | <0.05 |
Lymphocytes (×109/L) # | 2.4 (2.1–2.8) | 1.9 (1.6–2.3) | <0.05 |
Monocytes (×109/L) # | 0.6 (0.5–0.7) | 0.7 (0.5–0.8) | 0.331 |
NLR # | 1.6 (1.3–2.1) | 2.8 (2.0–4.3) | <0.01 |
PAB | NLR | |||
---|---|---|---|---|
OR (95% CI) | p | OR (95% CI) | p | |
Univariate | 1.026 (1.005–1.048) | <0.05 | 2.812 (1.206–6.568) | <0.05 |
Adjusted for: | ||||
Age (years) | 1.024 (1.003–1.046) | <0.05 | 2.684 (1.106–6.513) | <0.05 |
Diabetes duration (years) | 1.043 (1.008–1.080) | <0.05 | 2.915 (0.924–9.196) | 0.068 |
Smoking | 1.035 (1.009–1.062) | <0.05 | 2.621 (1.101–6.230) | <0.05 |
HbA1c (%) | 1.057 (1.014–1.102) | <0.05 | 4.632 (1.090–19.677) | <0.05 |
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Vujčić, S.; Kotur-Stevuljević, J.; Vekić, J.; Perović-Blagojević, I.; Stefanović, T.; Ilić-Mijailović, S.; Koprivica Uzelac, B.; Bosić, S.; Antonić, T.; Guzonjić, A.; et al. Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot. Medicina 2022, 58, 1866. https://doi.org/10.3390/medicina58121866
Vujčić S, Kotur-Stevuljević J, Vekić J, Perović-Blagojević I, Stefanović T, Ilić-Mijailović S, Koprivica Uzelac B, Bosić S, Antonić T, Guzonjić A, et al. Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot. Medicina. 2022; 58(12):1866. https://doi.org/10.3390/medicina58121866
Chicago/Turabian StyleVujčić, Sanja, Jelena Kotur-Stevuljević, Jelena Vekić, Iva Perović-Blagojević, Tatjana Stefanović, Sanja Ilić-Mijailović, Branka Koprivica Uzelac, Srećko Bosić, Tamara Antonić, Azra Guzonjić, and et al. 2022. "Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot" Medicina 58, no. 12: 1866. https://doi.org/10.3390/medicina58121866
APA StyleVujčić, S., Kotur-Stevuljević, J., Vekić, J., Perović-Blagojević, I., Stefanović, T., Ilić-Mijailović, S., Koprivica Uzelac, B., Bosić, S., Antonić, T., Guzonjić, A., Mastilović, A. -M., Marković, Z., & Rizzo, M. (2022). Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot. Medicina, 58(12), 1866. https://doi.org/10.3390/medicina58121866