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Article

The Predictive Role of Serum Levels of Soluble Cell Adhesion Molecules (sCAMs) in the Therapy of Advanced Breast Cancer—A Single-Centre Study

by
Weronika Bulska-Będkowska
1,*,
Paulina Czajka-Francuz
1,
Sylwia Jurek-Cisoń
1,
Aleksander J. Owczarek
2,
Tomasz Francuz
3 and
Jerzy Chudek
1
1
Department of Internal Diseases and Oncological Chemotherapy, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-027 Katowice, Poland
2
Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland
3
Department of Biochemistry, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland
*
Author to whom correspondence should be addressed.
Medicina 2022, 58(2), 153; https://doi.org/10.3390/medicina58020153
Submission received: 18 November 2021 / Revised: 16 January 2022 / Accepted: 17 January 2022 / Published: 19 January 2022
(This article belongs to the Section Oncology)
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Abstract

Background and Objectives: Soluble cell adhesion molecules (sCAMs) play a significant role in the metastatic potential of breast cancer (BC). They might block lymphocytes and promote angiogenesis and migration of cancer cells. We assessed the usefulness of sCAMs in the prognosis and monitoring of the progression of advanced BC. Materials and Methods: We assessed soluble E-selectin, P-selectin, VCAM-1, ICAM-1, EpCAM, IL-6Ra, TNF-R1, and TNF-R2 in 39 women with aBC. Blood samples were obtained at the beginning of the treatment and after 2 months. Results: The median progression-free survival (PFS) was 9 months, and overall survival (OS) was 27 months. The higher levels of sICAM-1 (HR = 2.60, p = 0.06) and lower levels of sEpCAM (HR = 2.72, p < 0.05) were associated with faster progression of aBC. High levels of sEpCAM through the follow-up period were significantly associated with a lower risk of progression (HR = 0.40, p < 0.01). We found the independent predictive value of higher than median sICAM-1 levels for PFS (HR = 2.07, p = 0.08) and of sVCAM-1 levels for OS (HR = 2.59, p < 0.05). Conclusions: Our data support the predictive value of sICAM-1 and sVCAM-1 and suggest that they could become markers for tailoring new therapies in aBC. sEpCAM level could be used as an early indicator of response to the therapy.
Keywords: breast cancer; soluble cell adhesion molecules; biomarkers; progression-free survival; overall survival breast cancer; soluble cell adhesion molecules; biomarkers; progression-free survival; overall survival

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MDPI and ACS Style

Bulska-Będkowska, W.; Czajka-Francuz, P.; Jurek-Cisoń, S.; Owczarek, A.J.; Francuz, T.; Chudek, J. The Predictive Role of Serum Levels of Soluble Cell Adhesion Molecules (sCAMs) in the Therapy of Advanced Breast Cancer—A Single-Centre Study. Medicina 2022, 58, 153. https://doi.org/10.3390/medicina58020153

AMA Style

Bulska-Będkowska W, Czajka-Francuz P, Jurek-Cisoń S, Owczarek AJ, Francuz T, Chudek J. The Predictive Role of Serum Levels of Soluble Cell Adhesion Molecules (sCAMs) in the Therapy of Advanced Breast Cancer—A Single-Centre Study. Medicina. 2022; 58(2):153. https://doi.org/10.3390/medicina58020153

Chicago/Turabian Style

Bulska-Będkowska, Weronika, Paulina Czajka-Francuz, Sylwia Jurek-Cisoń, Aleksander J. Owczarek, Tomasz Francuz, and Jerzy Chudek. 2022. "The Predictive Role of Serum Levels of Soluble Cell Adhesion Molecules (sCAMs) in the Therapy of Advanced Breast Cancer—A Single-Centre Study" Medicina 58, no. 2: 153. https://doi.org/10.3390/medicina58020153

APA Style

Bulska-Będkowska, W., Czajka-Francuz, P., Jurek-Cisoń, S., Owczarek, A. J., Francuz, T., & Chudek, J. (2022). The Predictive Role of Serum Levels of Soluble Cell Adhesion Molecules (sCAMs) in the Therapy of Advanced Breast Cancer—A Single-Centre Study. Medicina, 58(2), 153. https://doi.org/10.3390/medicina58020153

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