Comparison of the Effect of Sugammadex and Pyridostigmine on Postoperative Catheter-Related Bladder Discomfort: A Retrospective Matched Cohort Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Variables
2.3. Statistics
3. Results
3.1. Patient Characteristics
3.2. Incidence of CRBD
3.3. Odds Ratios for CRBD Occurrence in the Sugammadex Group
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Pyridostigmine (n = 968) | Sugammadex (n = 211) | |
---|---|---|
None | 728 (75.2) | 182 (86.2) |
Mild | 184 (19.0) | 18 (8.5) |
Moderate | 47 (4.8) | 8 (3.7) |
severe | 9 (0.9) | 3 (1.4) |
Before Matching | After Matching | |||||
---|---|---|---|---|---|---|
Pyridostigmine (n = 968) | Sugammadex (n = 211) | ASD | Pyridostigmine (n = 211) | Sugammadex (n = 211) | ASD | |
Age (years) | 60 [15] | 71 [14] | 0.79 | 71 [11] | 71 [14] | 0.01 |
Male sex | 468 (48.3) | 99 (46.9) | 0.02 | 100 (47.4) | 99 (46.9) | 0.01 |
BMI (kg/m2) | 24.8 [3.7] | 24.1 [4.1] | 0.16 | 24.3 [3.6] | 24.1 [4.1] | 0.05 |
Anesthesia time (min) | 128.2 [66.3] | 147.3 [90.9] | 0.21 | 146 [73.9] | 147.3 [90.9] | 0.01 |
BPH | 121 (12.5) | 38 (18) | 0.14 | 35 (16.6) | 38 (18) | 0.03 |
Parkinson’s Ds | 10 (1) | 5 (2.4) | 0.08 | 6 (2.8) | 5 (2.4) | 0.03 |
Catheter insertion timing | 0.27 | 0.00 | ||||
before | 463 (47.8) | 129 (61.1) | 129 (61.1) | 129 (61.1) | ||
after | 505 (52.2) | 82 (38.9) | 82 (38.9) | 82 (38.9) | ||
Catheter size (≥18 Fr) | 68 (7) | 13 (6.2) | 0.03 | 12 (5.7) | 13 (6.2) | 0.02 |
Anesthesia agent | 0.12 | 0.02 | ||||
inhalation | 880 (90.9) | 198 (93.8) | 199 (94.3) | 198 (93.8) | ||
TIVA | 88 (9.1) | 13 (6.2) | 12 (5.7) | 13 (6.2) | ||
Atropine use | 23 (2.4) | 7 (3.3) | 0.05 | 9 (4.3) | 7 (3.3) | 0.05 |
ASA PS 3-4 | 765 (79) | 201 (95.3) | 0.76 | 199 (94.3) | 201 (95.3) | 0.04 |
PCA | 533 (55.1) | 163 (77.3) | 0.52 | 168 (79.6) | 163 (77.3) | 0.05 |
Urology surgery | ||||||
not used scope | 208 (21.5) | 30 (14.2) | 0.2 | 30 (14.2) | 30 (14.2) | 0.00 |
used scope | 158 (16.3) | 23 (10.9) | 0.17 | 23 (10.9) | 23 (10.9) | 0.00 |
Laparoscopic surgery | 105 (10.8) | 34 (16.1) | 0.14 | 32 (15.2) | 34 (16.1) | 0.02 |
Odds Ratio (95% CI) | p-Value | ||
---|---|---|---|
UA | Pyridostigmine | Reference | |
sugammadex | 0.483 (0.318–0.734) | 0.001 | |
FAS | Pyridostigmine | Reference | |
sugammadex | 0.646 (0.397–1.052) | 0.079 | |
SA | Pyridostigmine | Reference | |
sugammadex | 0.611 (0.381–0.979) | 0.041 |
Odds Ratio (95% CI) | p-Value | ||
---|---|---|---|
UA | Pyridostigmine | Reference | |
sugammadex | 0.605 (0.362–1.011) | 0.055 | |
FAS | Pyridostigmine | Reference | |
sugammadex | 0.568 (0.316–1.021) | 0.059 | |
SA | Pyridostigmine | Reference | |
sugammadex | 0.544 (0.306–0.969) | 0.039 |
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Kwon, Y.-S.; Kim, J.-H.; Hwang, S.-M.; Choi, J.-W.; Kang, S.-S. Comparison of the Effect of Sugammadex and Pyridostigmine on Postoperative Catheter-Related Bladder Discomfort: A Retrospective Matched Cohort Analysis. Medicina 2022, 58, 590. https://doi.org/10.3390/medicina58050590
Kwon Y-S, Kim J-H, Hwang S-M, Choi J-W, Kang S-S. Comparison of the Effect of Sugammadex and Pyridostigmine on Postoperative Catheter-Related Bladder Discomfort: A Retrospective Matched Cohort Analysis. Medicina. 2022; 58(5):590. https://doi.org/10.3390/medicina58050590
Chicago/Turabian StyleKwon, Young-Suk, Jong-Ho Kim, Sung-Mi Hwang, Jae-Wang Choi, and Sang-Soo Kang. 2022. "Comparison of the Effect of Sugammadex and Pyridostigmine on Postoperative Catheter-Related Bladder Discomfort: A Retrospective Matched Cohort Analysis" Medicina 58, no. 5: 590. https://doi.org/10.3390/medicina58050590