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Open AccessArticle

Plasma Concentrations of Cytokines in Patients with Combined Hyperlipidemia and Atherosclerotic Plaque before Treatment Initiation—A Pilot Study

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medykow 18, 40-752 Katowice, Poland

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Medicina 2022, 58(5), 624; https://doi.org/10.3390/medicina58050624

Submission received: 21 March 2022 / Revised: 27 April 2022 / Accepted: 28 April 2022 / Published: 29 April 2022

(This article belongs to the Special Issue The Management of Chronic Coronary Arterial Disease and Related Comorbidities)

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Abstract

Background and Objectives: The formation and destabilization of atherosclerotic plaques is a complex process involving several proteins and cytokines. Interleukin 6 (IL-6), interleukin 18 (IL-18), and tumor necrosis factor (TNF-α) are examples of such cytokines. The goal of our research is to compare the concentrations of the above-mentioned indicators in the plasma of patients with verified high-risk atherosclerotic plaque to the plasma levels of healthy people before lipid lowering therapy. Materials and Methods: Patients with dyslipidemia who had the presence of unstable atherosclerotic plaque verified by ultrasonography were included in the study. The concentrations of IL-6, IL-18 and TNF-α in the plasma of these people were determined and compared with the concentrations of these cytokines in the plasma of the control group. Results: Levels of lipid panel, IL-6 and IL-18 were significantly lower in the group of healthy people than in the study group. Conclusions: The concentrations of IL-6 and IL-18 in the plasma of patients with ruptured plaque are higher than in the plasma of healthy people, suggesting that these cytokines as a panel might be used as new indicators of the presence of unstable atherosclerotic plaque.

Keywords: atherosclerosis; hyperlipidemia; rupture plaque; interleukin 6; interleukin 18; tumor necrosis factor alfa

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MDPI and ACS Style

Basiak, M.; Kosowski, M.; Hachula, M.; Okopien, B. Plasma Concentrations of Cytokines in Patients with Combined Hyperlipidemia and Atherosclerotic Plaque before Treatment Initiation—A Pilot Study. Medicina 2022, 58, 624. https://doi.org/10.3390/medicina58050624

AMA Style

Basiak M, Kosowski M, Hachula M, Okopien B. Plasma Concentrations of Cytokines in Patients with Combined Hyperlipidemia and Atherosclerotic Plaque before Treatment Initiation—A Pilot Study. Medicina. 2022; 58(5):624. https://doi.org/10.3390/medicina58050624

Chicago/Turabian Style

Basiak, Marcin, Michal Kosowski, Marcin Hachula, and Boguslaw Okopien. 2022. "Plasma Concentrations of Cytokines in Patients with Combined Hyperlipidemia and Atherosclerotic Plaque before Treatment Initiation—A Pilot Study" Medicina 58, no. 5: 624. https://doi.org/10.3390/medicina58050624

APA Style

Basiak, M., Kosowski, M., Hachula, M., & Okopien, B. (2022). Plasma Concentrations of Cytokines in Patients with Combined Hyperlipidemia and Atherosclerotic Plaque before Treatment Initiation—A Pilot Study. Medicina, 58(5), 624. https://doi.org/10.3390/medicina58050624

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