Value of Serum Sirtuin-1 (SIRT1) Levels and SIRT1 Gene Variants in Periodontitis Patients
Round 1
Reviewer 1 Report
The contents of the manuscript were useful and informative. Please find my comment in the attachment
Comments for author File: Comments.pdf
Author Response
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Author Response File: Author Response.docx
Reviewer 2 Report
- In Material and method section please explain about the sampling method of this study
- one of the exclusion criteria of this study that tooth loss wasnot due to periodontal disease but to other causes --> please add information : how can you get the information about the cause of tooth loss since the tooth already lossin the time of study
- Please explain about the design of your study , whether it is a case control study since you choose sample in 2 groups cases and control ? but I didnt find any information in the study about this
- Is there any other variables included in your study such as oral hygienne ofthe subjects ? since those variables is the confounding factors that can affect the result of your study.Please add information about this.
Author Response
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Author Response File: Author Response.docx
Reviewer 3 Report
sample size calculation has not been performed. I can be argued that the sample is not big enough to draw definitive conclusions.
Author Response
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Author Response File: Author Response.docx