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Article
Peer-Review Record

Value of Serum Sirtuin-1 (SIRT1) Levels and SIRT1 Gene Variants in Periodontitis Patients

Medicina 2022, 58(5), 653; https://doi.org/10.3390/medicina58050653
by Albertas Kriaučiūnas 1,*, Rasa Liutkevičienė 2, Greta Gedvilaitė 2, Kristė Kaikarytė 2, Alvita Vilkevičiūtė 2, Darius Gleiznys 1, Ingrida Pacauskienė 3 and Gediminas Žekonis 1
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Medicina 2022, 58(5), 653; https://doi.org/10.3390/medicina58050653
Submission received: 19 April 2022 / Revised: 9 May 2022 / Accepted: 11 May 2022 / Published: 12 May 2022
(This article belongs to the Section Dentistry)

Round 1

Reviewer 1 Report

The contents of the manuscript were useful and informative. Please find my comment in the attachment

Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

  1. In Material and method section please explain about the sampling method of this study
  2. one of the exclusion criteria of this study that tooth loss wasnot due to periodontal disease  but to other causes --> please add information  : how can you  get the information about the cause of tooth loss  since the tooth already lossin the time of study
  3. Please  explain  about the design of your study , whether it is a case control study since you  choose sample in 2 groups  cases and control ? but I didnt find any information in the study about this
  4. Is there any other variables included in your study such as oral hygienne  ofthe subjects ? since those variables is the confounding factors that can affect the result of your study.Please add information about this.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 3 Report

sample size calculation has not been performed. I can be argued that the sample is not big enough to draw definitive conclusions.

 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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