Protecting Tear-Film Stability under Adverse Environmental Conditions Using a Mucomimetic with a Non-Newtonian Viscosity Agent
Abstract
:1. Introduction
2. Methods
2.1. Controlled Environment Chamber (CEC)
2.2. Scheme of Investigation
2.3. Treatment Protocol
- Typical environment (21 °C/40% RH).
- Dry environment (21 °C/5% RH).
2.4. Parameters Assessed
2.5. Non-Invasive Tear Break-Up Time (NITBUT)
2.6. Ocular Surface Temperature Measurement (OST)
2.7. Tear-Film Evaporation Rate (TFER)
2.8. Statistical Analysis
3. Result
3.1. Lipid-Layer Thickness (LLT)
3.2. Evaporation Rate
3.3. Non-Invasive Tear Break-Up Time (NITBUT)
3.4. Correlation Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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EVAP (g/m2/h) | NITBUT (s) | OST (°C) | |
---|---|---|---|
40% RH | 40.93 ± 12.49 | 13.00 ± 2.1 | 33.99 ± 0.66 |
5% RH | 82.42 ± 14.66 | 6.00 ± 1.82 | 33.70 ± 0.44 |
Protection | 56.45 ± 18.13 | 8.00 ± 1.94 | 33.50 ± 0.41 |
Relief | 75.38 ± 22.84 | 8.00 ± 2.41 | 33.92 ± 0.59 |
LLT 40% | LLT 5% | LLT Protection | LLT Relief | |
---|---|---|---|---|
LLT 40% | 0.007 | 0.725 | 0.803 | |
LLT 5% | 0.011 | 0.004 | ||
LLT Protection | 0.53 |
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Abusharha, A.; Pearce, E.I.; Afsar, T.; Razak, S. Protecting Tear-Film Stability under Adverse Environmental Conditions Using a Mucomimetic with a Non-Newtonian Viscosity Agent. Medicina 2023, 59, 1862. https://doi.org/10.3390/medicina59101862
Abusharha A, Pearce EI, Afsar T, Razak S. Protecting Tear-Film Stability under Adverse Environmental Conditions Using a Mucomimetic with a Non-Newtonian Viscosity Agent. Medicina. 2023; 59(10):1862. https://doi.org/10.3390/medicina59101862
Chicago/Turabian StyleAbusharha, Ali, E. Ian Pearce, Tayyaba Afsar, and Suhail Razak. 2023. "Protecting Tear-Film Stability under Adverse Environmental Conditions Using a Mucomimetic with a Non-Newtonian Viscosity Agent" Medicina 59, no. 10: 1862. https://doi.org/10.3390/medicina59101862