The Effects of Lumbricus rubellus Extract on Staphylococcus aureus Colonization and IL-31 Levels in Children with Atopic Dermatitis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Study Population
2.3. Randomization
2.4. Blinding of Participants
2.5. Study Procedure
2.6. Measurement of IL-31 Serum Level
2.7. Measurement of S. aureus Colony
2.8. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristics | Control Group (n = 20) | Intervention Group (n = 20) | p-Value |
---|---|---|---|
Age, (mean ± SD), y | 11.1 ± 2.26 | 10.75 ± 2.17 | 0.621 |
Gender, n (%) | 0.327 | ||
Male | 9 (45) | 6 (30) | |
Female | 11 (55) | 14 (70) | |
History of atopy, n (%) | 0.795 | ||
Food allergy | 7 (35) | 6 (30) | |
Allergic rhinitis | 3 (15) | 4 (20) | |
Bronchial asthma | 4 (20) | 6 (30) | |
None | 6 (30) | 4 (20) | |
SCORAD index at baseline, mean ± SD | 50.28 ± 9.3 | 50.51 ± 9.94 | 0.939 |
SCORAD index at the end of the study, mean ± SD | 36.85 ± 8.15 | 26.05 ± 7.69 | <0.001 * |
Pruritus intensity at the baseline (subjective), median (min–max) | 6 (4–8) | 6 (4–8) | 0.901 |
Pruritus intensity at the end of the study (subjective), median (min–max) | 4 (2–6) | 2 (0–5) | 0.003 * |
Number of S. aureus colony at the baseline, median (min–max) | 2 (0–3) | 2 (0–3) | 0.806 |
Number of S. aureus colony at the end of the study, median (min–max) | 1 (0–3) | 0 (0–1) | 0.001 * |
IL-31 level at baseline, median (min–max) | 73.12 (46.82–258.1) | 78.97 (45.15–297.28) | 0.685 |
IL-31 level at the end of the study, median (min–max) | 49.4 (30.67–231.51) | 42.05 (25.95–173.97) | 0.185 |
SCORAD Index | Median | Min–Max | p-Value * |
---|---|---|---|
Control, n = 20 | 9 | 1.4–36.4 | 0.005 |
Intervention, n = 20 | 26 | 7.2–41.7 |
S. aureus Colonization | Median | Min–Max | p-Value |
---|---|---|---|
Control, n = 20 | 1 | 0–2 | 0.001 * |
Intervention, n = 20 | 2 | 0–3 |
IL-31 Serum Levels | Median | Min–Max | p-Value |
---|---|---|---|
Control, n = 20 | 20.41 | 9.95–68.17 | 0.013 * |
Intervention, n = 20 | 34.18 | 9.56–124.24 |
Group | SCORAD Index Improvement ≥ 35% | SCORAD Index Improvement < 35% | p-Value |
---|---|---|---|
Control, n = 20 | 8 (20%) | 12 (30%) | |
Intervention, n = 20 | 14 (35%) | 6 (15%) | 0.057 * |
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Sara, M.; Ilyas, F.; Hasballah, K.; Nurjannah, N.; Mudatsir, M. The Effects of Lumbricus rubellus Extract on Staphylococcus aureus Colonization and IL-31 Levels in Children with Atopic Dermatitis. Medicina 2023, 59, 2007. https://doi.org/10.3390/medicina59112007
Sara M, Ilyas F, Hasballah K, Nurjannah N, Mudatsir M. The Effects of Lumbricus rubellus Extract on Staphylococcus aureus Colonization and IL-31 Levels in Children with Atopic Dermatitis. Medicina. 2023; 59(11):2007. https://doi.org/10.3390/medicina59112007
Chicago/Turabian StyleSara, Meutia, Faridha Ilyas, Kartini Hasballah, Nurjannah Nurjannah, and Mudatsir Mudatsir. 2023. "The Effects of Lumbricus rubellus Extract on Staphylococcus aureus Colonization and IL-31 Levels in Children with Atopic Dermatitis" Medicina 59, no. 11: 2007. https://doi.org/10.3390/medicina59112007