Afatinib-Induced Tumor Lysis Syndrome in Pulmonary Adenocarcinoma: A Case Report and Literature Review
Abstract
:1. Introduction
2. Case Report
3. Discussion
4. Conclusions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameters | Reference Range | Day of Admission | 4th Day Morning of Afatinib Administration | 4th Day Evening of Afatinib Administration | During CRRT (5th Day of Afatinib Administration) |
---|---|---|---|---|---|
BUN (mg/dL) | 6–20 | 15.0 | 55.0 | 63 | 30.0 |
Creatinine (mg/dL) | 0.7–1.2 | 0.96 | 2.2 | 3.07 | 2.57 |
Potassium (mmol/L) | 3.5–5.5 | 4.3 | 5.9 | 6.1 | 4.4 |
Phosphorous (mg/dL) | 2.7–4.5 | 2.5 | 7.0 | 9.6 | 4.4 |
Calcium (mg/dL) | 8.4–10.4 | 8.6 | 8.0 | 7.7 | 7.7 |
Uric acid (mg/dL) | 3.4–7.0 | 4.5 | 10.0 | 12 | 8.2 |
LDH (U/L) | 135–250 | 247 | 1082 | 8202 | 8113 |
Case | Sex/Age | Chemotherapy | Metastasis | Onset Interval | Outcome |
---|---|---|---|---|---|
Persons [16] | F/38 | Irinotecan + cisplatin | Lymph nodes | 13 days | Survived |
Feld [17] | M/72 | Spontaneous | Liver | N/A | Died |
Kurt [18] | M/52 | Zoledronic acid | Brain, liver, paraspinal, bones, and small intestine | 4 days | Died |
Ajzensztejn [19] | M/65 | Docetaxel | Liver, kidneys, and adrenals | 3 days | Died |
Honda [20] | M/61 | Carboplatin + paclitaxel + bevacizumab | Liver and lymph nodes | N/A | Died |
Eguchi [9] | M/73 | Gefitinib | Bones and lymph nodes | 5 days | Died |
Wang [10] | M/39 | Brigatinib | Pleura and lymph nodes | 22 days | Died |
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Hong, G. Afatinib-Induced Tumor Lysis Syndrome in Pulmonary Adenocarcinoma: A Case Report and Literature Review. Medicina 2023, 59, 2144. https://doi.org/10.3390/medicina59122144
Hong G. Afatinib-Induced Tumor Lysis Syndrome in Pulmonary Adenocarcinoma: A Case Report and Literature Review. Medicina. 2023; 59(12):2144. https://doi.org/10.3390/medicina59122144
Chicago/Turabian StyleHong, Goohyeon. 2023. "Afatinib-Induced Tumor Lysis Syndrome in Pulmonary Adenocarcinoma: A Case Report and Literature Review" Medicina 59, no. 12: 2144. https://doi.org/10.3390/medicina59122144