Does Adjustment of Antiseizure Medication Regimen after Failed Epilepsy Surgery Improve Outcomes?
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Postoperative Management
2.3. Data Collection
2.4. Data Analysis
3. Results
3.1. Postoperative Management
3.2. The Relationship between ASM Regimens and Outcomes
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristic (n = 63) | Number of Patients (%)/ Mean ± SD (Range) |
---|---|
Gender | |
Male | 36 (57.1%) |
Female | 27 (42.9%) |
Duration of epilepsy, months | 17.1 ± 25.7 (1–110) |
Seizure type | 77.9 ± 37.6 (18–192) |
Focal seizure | 36 (57.1%) |
Generalized seizure | 27 (42.9%) |
Surgical site | 58 (48.7%) |
Temporal | 22 (34.9%) |
Extratemporal | 41 (65.1%) |
Incomplete resection | 24 (38.1%) |
Recurrence time, months | 4.8 ± 3.4 (1–16) |
Early recurrence | 42 (66.7%) |
ASM regimen adjustment | 40 (63.5%) |
Increased dosage | 38 (60.3%) |
Alternative therapy | 11 (17.5%) |
Combination therapy | 17 (27.0%) |
Variable | Seizure Freedom (n = 23) | Seizure Remission (n = 26) | Good QoL (n = 39) | |||
---|---|---|---|---|---|---|
Statistics | p Value | Statistics | p Value | Statistics | p Value | |
Gender | 0.01 | 0.94 | 0.01 | 0.94 | 0.81 | 0.37 |
Duration of epilepsy | −0.17 | 0.86 | −0.34 | 0.74 | −0.57 | 0.57 |
Seizure type | 2.28 | 0.13 | 1.23 | 0.27 | 2.03 | 1.56 |
Surgery site | 1.24 | 0.27 | 1.25 | 0.26 | 1.68 | 0.20 |
Incomplete resection | 2.22 | 0.14 | 4.23 | 0.04 * | 0.21 | 0.65 |
Early recurrence | 5.79 | 0.02 * | 5.53 | 0.02 * | 7.57 | 0.01 * |
ASM regimen adjustment | 2.00 | 1.58 | 1.78 | 0.18 | 1.67 | 0.68 |
Increased dosage | 1.00 | 0.32 | 0.77 | 0.38 | 0.08 | 0.78 |
Alternative therapy | 0.13 | 0.72 | 1.08 | 0.30 | 1.53 | 0.22 |
Combination therapy | 0.02 | 0.90 | 0.32 | 0.57 | 2.01 | 0.15 |
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Wu, Y.; Zhang, Z.; Liang, P.; Li, L.; Zou, B.; Wang, D.; Dong, X.; Tang, H.; Qiu, H.; Zhai, X. Does Adjustment of Antiseizure Medication Regimen after Failed Epilepsy Surgery Improve Outcomes? Medicina 2023, 59, 785. https://doi.org/10.3390/medicina59040785
Wu Y, Zhang Z, Liang P, Li L, Zou B, Wang D, Dong X, Tang H, Qiu H, Zhai X. Does Adjustment of Antiseizure Medication Regimen after Failed Epilepsy Surgery Improve Outcomes? Medicina. 2023; 59(4):785. https://doi.org/10.3390/medicina59040785
Chicago/Turabian StyleWu, Yuxin, Zaiyu Zhang, Ping Liang, Lusheng Li, Bin Zou, Difei Wang, Xinyu Dong, Haotian Tang, Hanli Qiu, and Xuan Zhai. 2023. "Does Adjustment of Antiseizure Medication Regimen after Failed Epilepsy Surgery Improve Outcomes?" Medicina 59, no. 4: 785. https://doi.org/10.3390/medicina59040785