Next Article in Journal
A Systematic Review Investigating the Difference between 1 Cycle versus 2 Cycles of Adjuvant Chemotherapy in Stage I Testicular Germ Cell Cancers
Previous Article in Journal
Necrotizing Skin and Soft Tissue Infection after Gluteal Augmentation in a Perioperatively Asymptomatic COVID-19 Patient—Complications of the Post-Lockdown Era? A Case Report
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Medicina
Volume 59
Issue 5
10.3390/medicina59050915
Review Report
medicina-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

Urinary Biomarkers in Monitoring the Progression and Treatment of Autosomal Dominant Polycystic Kidney Disease—The Promised Land?

Medicina 2023, 59(5), 915; https://doi.org/10.3390/medicina59050915
by Camelia Pana 1,*, Alina Mihaela Stanigut 1,*, Bogdan Cimpineanu 2, Andreea Alexandru 3, Camer Salim 4, Alina Doina Nicoara 2, Periha Resit 5 and Liliana Ana Tuta 1,*
Reviewer 1: Anonymous
Medicina 2023, 59(5), 915; https://doi.org/10.3390/medicina59050915
Submission received: 8 April 2023 / Revised: 27 April 2023 / Accepted: 28 April 2023 / Published: 10 May 2023
(This article belongs to the Section Urology & Nephrology)

Round 1

Reviewer 1 Report

Overall, this review covers a number of novel biomarkers in monitoring the progress of ADPKD and their therapeutic potential. The manuscript is very well written and informative. Therefore, I only have a minor suggestion to improve the manuscript:

As many biomarkers are shared between CKD and ADPKD. In the manuscript, I would suggest to highlight the specific biomarkers that have been shown to be more specific to ADPKD and can aid in diagnosis and treatment.

Author Response

Thank you for this very good suggestion and i consider that a clarification of this aspect was necessary. That's why a added considerations regarding the specificity for ADPKD of some of urinary biomarkers in discussions section. 

Reviewer 2 Report

This study is a systematic review that considers different urinary biomarkers in monitoring the progression and treatment of autosomal dominant polycystic kidney disease (ADPKD).

It is a very good paper based on up to date references (96 of them), involving two very useful figures and a table summarizing the various urinary markers in ADPKD.

The manuscript consists of an introduction (related to the incidence and main pathophysiological mechanisms of ADPKD), a comprehensive overview of new biomarkers in ADPKD, a brief discussion and conclusion.

I will just suggest the authors to add a Material and Methods section with the database they used, key words and criteria for inclusion of the articles in the study.

Author Response

Thank you for this very useful suggestion. I will include a Material and Method section in the article.

Back to TopTop