Therapeutic Effects of Treating COVID-19 Vaccine-Induced Anti-TIF1-γ-Positive Dermatomyositis
Abstract
:1. Introduction
2. Case Report
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Classification Criteria | Yes/No | Our Patient |
---|---|---|
Age of onset of first symptom | Yes | 90 years old |
Objective symmetric weakness, usually progressive, of the proximal upper extremities | Yes | Muscle power in both sides’ proximal upper extremities scored 2, and distal scored 3 |
Objective symmetric weakness, usually progressive, of the proximal lower extremities | Yes | Muscle power in both sides’ proximal lower extremities scored 1, and distal scored 2 |
Neck flexors are relatively weaker than neck extensors | No | General weakness of her neck |
In the legs, proximal muscles are relatively weaker than distal muscles | Yes | Muscle power in both sides’ proximal lower extremities scored 1, and distal scored 2 |
Heliotrope rash | No | Skin rash on her face, probable but could not accurately be defined as Heliotrope rash |
Gottron’s papules | No | Probable but could not define |
Gottron’s sign | No | Probable but could not define |
Dysphagia or esophageal dysmotility | Yes | Dysphagia |
Anti-Jo-1 (anti-Histidyl-tRNA synthetase) autoantibody positivity | No | Negative |
Elevated serum levels of CK or LDH or AST or alanine aminotransferase (ALT) | Yes | CK: 4858 U/L (normal range 41–153 U/L) LDH: 380 U/L (normal range < 40 U/L) AST: 72 U/L (normal range < 40 U/L) |
Endomysial infiltration of mononuclear cells surrounding, but not invading, myofibers | Yes | Muscle biopsy |
Perimysial and/or perivascular infiltration of mononuclear cells | Yes | Muscle biopsy |
Perifascicular atrophy | Yes | Muscle biopsy |
Rimmed vacuoles | No | Absent |
Score: 11.4 (>8.7), 99% probability of diagnosing as dermatomyositis |
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Wu, C.-F.; Chen, W.-T.; Chen, Y.-L.; Liu, F.-C. Therapeutic Effects of Treating COVID-19 Vaccine-Induced Anti-TIF1-γ-Positive Dermatomyositis. Medicina 2023, 59, 1688. https://doi.org/10.3390/medicina59091688
Wu C-F, Chen W-T, Chen Y-L, Liu F-C. Therapeutic Effects of Treating COVID-19 Vaccine-Induced Anti-TIF1-γ-Positive Dermatomyositis. Medicina. 2023; 59(9):1688. https://doi.org/10.3390/medicina59091688
Chicago/Turabian StyleWu, Chih-Feng, Wan-Ting Chen, Yen-Lin Chen, and Feng-Cheng Liu. 2023. "Therapeutic Effects of Treating COVID-19 Vaccine-Induced Anti-TIF1-γ-Positive Dermatomyositis" Medicina 59, no. 9: 1688. https://doi.org/10.3390/medicina59091688