Identifying the Risk Factors for Orbital Complications in Isolated Sphenoid Rhinosinusitis
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Fokkens, W.J.; Lund, V.J.; Hopkins, C.; Hellings, P.W.; Kern, R.; Reitsma, S.; Toppilasalmi, S.; Bernalsprekelsen, M.; Mullol, J.; Alobid, I. European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology 2020, 58 (Suppl. S29), 1–464. [Google Scholar] [CrossRef]
- Hellings, P.; Fokkens, W.; Orlandi, R.; Adriaensen, G.; Alobid, I.; Baroody, F.; Bjermer, L.; Senior, B.; Cervin, A.; Cohen, N.; et al. The EUFOREA pocket guide for chronic rhinosinusitis. Rhinology 2023, 61, 85–89. [Google Scholar] [CrossRef]
- Fooanant, S.; Angkurawaranon, S.; Angkurawaranon, C.; Roongrotwattanasiri, K.; Chaiyasate, S. Sphenoid Sinus Diseases: A Review of 1442 Patients. Int. J. Otolaryngol. 2017, 2017, 9650910. [Google Scholar]
- Krishnan, R.D.Y.; Kumarasekaran, P.; Raja, R.V. Isolated Sphenoid Sinusitis. Indian J. Otolaryngol. Head Neck Surg. 2019, 71 (Suppl. S3), 1762–1764. [Google Scholar] [CrossRef]
- Fadda, G.L.; D’Eramo, A.; Grosso, A.; Galizia, A.; Cavallo, G. Isolated Sphenoid Sinus Inflammatory Disease-A Report of 14 Cases. Iran. J. Otorhinolaryngol. 2020, 32, 101–107. [Google Scholar]
- Fan, Y.; Wu, P.; Huang, Y.; Lee, C.; Lee, T.; Huang, C.; Chang, P. Identifying a sphenoid sinus fungus ball using a nomogram model. Rhinology 2023, 61, 153–160. [Google Scholar] [CrossRef]
- Kim, S.W.; Kim, D.W.; Kong, I.G.; Kim, D.-Y.; Park, S.-W.; Rhee, C.-S.; Min, Y.-G. Isolated sphenoid sinus diseases: Report of 76 cases. Acta Otolaryngol. 2008, 128, 455–459. [Google Scholar]
- Charakorn, N.; Snidvongs, K. Chronic sphenoid rhinosinusitis: Management challenge. J. Asthma Allergy. 2016, 9, 199–205. [Google Scholar] [CrossRef]
- Nour, Y.A.; Al-Madani, A.; El-Daly, A.; Gaafar, A. Isolated sphenoid sinus pathology: Spectrum of diagnostic and treatment modalities. Auris Nasus Larynx 2008, 35, 500–508. [Google Scholar] [CrossRef]
- Hu, L.; Wang, D.; Yu, H. Isolated sphenoid fungal sinusitis and vision loss: The case for early intervention. J. Laryngol. Otol. 2009, 123, e8. [Google Scholar] [CrossRef]
- Chen, L.; Jiang, L.; Yang, B.; Subramanian, P.S. Clinical features of visual disturbances secondary to isolated sphenoid sinus inflammatory diseases. BMC Ophthalmol. 2017, 17, 237. [Google Scholar] [CrossRef]
- Suarez, R.I.; Polmann, M.B.; Portnoy, W.M.; Quintero, E.; Bedran, K. Isolated Abducens Nerve Palsy in the Setting of Isolated Sphenoid Sinusitis: A Case Report. Cureus 2023, 15, e46993. [Google Scholar] [CrossRef] [PubMed]
- Leong, W.S.; Mulla, O. Lateral rectus muscle palsy secondary to sphenoid sinusitis. Ann. R. Coll. Surg. Engl. 2022, 104, e239–e243. [Google Scholar] [CrossRef] [PubMed]
- Wang, Y.H.; Chen, P.Y.; Ting, P.J.; Huang, F.L. A review of eight cases of cavernous sinus thrombosis secondary to sphenoid sinusitis, including a 12-year-old girl at the present department. Infect. Dis. 2017, 49, 641–646. [Google Scholar] [CrossRef] [PubMed]
- Chopra, H.; Dua, K.; Malhotra, V.; Gupta, R.P.; Puri, H. Invasive fungal sinusitis of isolated sphenoid sinus in immunocompetent subjects. Mycoses 2006, 49, 30–36. [Google Scholar] [CrossRef] [PubMed]
- Wu, P.; Huang, Y.; Yang, S.; Lee, Y.; Huang, C.; Chang, P.; Lee, T. Acute invasive fungal rhinosinusitis in twenty-one diabetic patients. Clin. Otolaryngol. 2018, 43, 1163–1167. [Google Scholar] [CrossRef]
- Montone, K.T. Pathology of fungal rhinosinusitis: A review. Head Neck Pathol. 2016, 10, 40–46. [Google Scholar] [CrossRef]
- Ada, M.; Kaytaz, A.; Tuskan, K.; Güvenç, M.G.; Selçuk, H. Isolated sphenoid sinusitis presenting with unilateral VIth nerve palsy. Int. J. Pediatr. Otorhinolaryngol. 2004, 68, 507–510. [Google Scholar] [CrossRef]
- Nowacka, B.; Lubiński, W.; Lubiński, J. Optic Neuritis Related to Chronic Sphenoid Sinusitis as an Uncommon Cause of Vision Loss: A Case Report and Literature Review. Am. J. Case Rep. 2023, 24, e939267. [Google Scholar] [CrossRef]
- Celenk, F.; Gulsen, S.; Gonuldas, B.; Baysal, E.; Durucu, C.; Kanlikama, M.; Mumbuc, S. Isolated sphenoid sinus disease: An overlooked cause of headache. J. Craniomaxillofac. Surg. 2015, 43, 1914–1917. [Google Scholar] [CrossRef]
- Wu, P.-W.; Lee, T.-J.; Yang, S.-W.; Huang, Y.; Lee, Y.-S.; Ho, C.-F.; Huang, C.-C. Differences in clinical and imaging presentation of maxillary sinus fungus ball with and without intralesional hyperdensity. Sci. Rep. 2021, 11, 23945. [Google Scholar] [CrossRef] [PubMed]
- Fan, Y.-H.; Shih, K.-Y.; Wu, P.-W.; Huang, Y.-L.; Lee, T.-J.; Huang, C.-C.; Chang, P.-H.; Huang, C.-C. Predicting the Probability of the Incidence of Maxillary Sinus Fungus Ball in Patients Using Nomogram Models. Diagnostics 2023, 13, 3156. [Google Scholar] [CrossRef] [PubMed]
- Jiang, T.; Zhang, Q.; Li, C.; Li, T.; Sun, S.; Chen, A.; Ji, H.; Wan, Y.; Shi, L.; Yu, L. Clinical Characteristics of Sphenoid Sinus Fungus Ball: A Nine-year Retrospective Study of 77 Cases. Laryngoscope 2023, 133, 3292–3298. [Google Scholar] [CrossRef]
- Shen, T.Y.; Strong, C.; Yu, T. Age at menopause and mortality in Taiwan: A cohort analysis. Maturitas 2020, 136, 42–48. [Google Scholar] [CrossRef] [PubMed]
- Haeggström, A.; Östberg, B.; Stjerna, P.; Graf, P.; Hallén, H. Nasal mucosal swelling and reactivity during a menstrual cycle. ORL-J. Oto-Rhino-Laryngol. Head Neck Surg. 2000, 62, 39–42. [Google Scholar] [CrossRef] [PubMed]
- Özler, G.S.; Akbay, E.; Akkoca, A.N.; Karapınar, O.S.; Şimşek, G. Does menopause effect nasal mucociliary clearance time? Eur. Arch. Otorhinolaryngol. 2015, 272, 363–366. [Google Scholar] [CrossRef]
- Gumussoy, S.; Gumussoy, M.; Hortu, I.; Ergenoglu, A.M. The effect of surgical menopause after bilateral oophorectomy on hormonal changes, mucociliary clearance, and quality of life. Eur. Arch Otorhinolaryngol. 2020, 277, 2793–2800. [Google Scholar] [CrossRef]
- Haimi-Cohen, Y.; Amir, J.; Zeharia, A.; Danziger, Y.; Ziv, N.; Mimouni, M. Isolated sphenoidal sinusitis in children. Eur. J. Pediatr. 1999, 158, 298–301. [Google Scholar] [CrossRef]
- Kotowski, M.; Szydlowski, J. Isolated Sphenoid Sinus Disease in Children. Int. J. Environ. Res. Public Health 2023, 20, 847. [Google Scholar] [CrossRef]
- Chiang, P.T.; Luo, S.D.; Ho, R.W.; Wu, C.N.; Fang, K.C.; Chen, W.C. A Multi-Institutional Database Review of Orbital Complications and Survival Outcomes in Adult Patients with Invasive or Non-Invasive Fungal Rhinosinusitis. J. Fungi 2022, 8, 1239. [Google Scholar] [CrossRef]
- Muszewska, A.; Pawłowska, J.; Krzyściak, P. Biology, systematics, and clinical manifestations of Zygomycota infections. Eur. J. Clin. Microbiol. Infect. Dis. 2014, 33, 1273–1287. [Google Scholar] [CrossRef]
- Yohai, R.A.; Bullock, J.D.; Aziz, A.A.; Markert, R.J. Survival factors in rhino-orbital-cerebral mucormycosis. Surv. Ophthalmol. 1994, 39, 3–22. [Google Scholar] [CrossRef] [PubMed]
- Nyunt, T.P.K.; Mullol, J.; Snidvongs, K. Immune response to fungi in diabetic patients with invasive fungal rhinosinusitis. Asian Pac. J. Allergy Immunol. 2020, 38, 233–238. [Google Scholar] [PubMed]
- Yaguchi, T.; Sumimoto, H.; Kudo-Saito, C.; Tsukamoto, N.; Ueda, R.; Iwata-Kajihara, T.; Nishio, H.; Kawamura, N.; Kawakami, Y. The mechanisms of cancer immunoescape and development of overcoming strategies. Int. J. Hematol. 2011, 93, 294–300. [Google Scholar] [CrossRef]
- Wu, P.-W.; Huang, C.-C.; Lee, Y.-S.; Chou, Y.-C.; Fan, K.-H.; Lin, C.-Y.; Huang, B.-S.; Yang, S.-W.; Huang, C.-C.; Chang, P.-H.; et al. Post-Irradiation Sinus Mucosa Disease in Nasopharyngeal Carcinoma Patients Treated with Intensity-Modulated Proton Therapy. Cancers 2022, 14, 225. [Google Scholar] [CrossRef]
- Munzen, M.E.; Goncalves Garcia, A.D.; Martinez, L.R. An update on the global treatment of invasive fungal infections. Future Microbiol. 2023, 18, 1095–1117. [Google Scholar] [CrossRef] [PubMed]
- Ho, C.F.; Lee, T.J.; Wu, P.W.; Huang, C.C.; Chang, P.H.; Huang, Y.L.; Lee, Y.L.; Huang, C.C. Diagnosis of a maxillary sinus fungus ball without intralesional hyperdensity on computed tomography. Laryngoscope 2019, 129, 1041–1045. [Google Scholar] [CrossRef]
- Bhandarkar, N.D.; Sautter, N.B.; Kennedy, D.W.; Smith, T.L. Osteitis in chronic rhinosinusitis: A review of the literature. Int. Forum Allergy Rhinol. 2013, 3, 355–363. [Google Scholar] [CrossRef]
- Huang, C.C.; Wang, C.H.; Wu, P.W.; He, J.R.; Huang, C.C.; Chang, P.H.; Fu, C.H. Increased nasal matrix metalloproteinase-1 and -9 expression in smokers with chronic rhinosinusitis and asthma. Sci. Rep. 2019, 9, 15357. [Google Scholar] [CrossRef]
- Erlebacher, A.; Filvaroff, E.H.; Ye, J.Q.; Derynck, R. Osteoblastic responses to TGF-beta during bone remodeling. Mol. Biol. Cell 1998, 9, 1903–1918. [Google Scholar] [CrossRef]
- Lee, J.T.; Kennedy, D.W.; Palmer, J.N.; Feldman, M.; Chiu, A.G. The incidence of concurrent osteitis in patients with chronic rhinosinusitis: A clinicopathological study. Am. J. Rhinol. 2006, 20, 278–282. [Google Scholar] [CrossRef] [PubMed]
- Snidvongs, K.; Sacks, R.; Harvey, R.J. Osteitis in Chronic Rhinosinusitis. Curr. Allergy Asthma Rep. 2019, 19, 24. [Google Scholar] [CrossRef] [PubMed]
- Odat, H.; Almardeeni, D.; Tanash, M.; Al-Qudah, M. Anatomical variation of the sphenoid sinus in paediatric patients and its association with age and chronic rhinosinusitis. J. Laryngol. Otol. 2019, 133, 482–486. [Google Scholar] [CrossRef] [PubMed]
- Grillone, G.A.; Kasznica, P. Isolated sphenoid sinus disease. Otolaryngol. Clin. N. Am. 2004, 37, 435–451. [Google Scholar] [CrossRef]
- Aribandi, M.; Bazan, C., 3rd. CT and MRI features in Bipolaris fungal sinusitis. Australas. Radiol. 2007, 51, 127–132. [Google Scholar] [CrossRef] [PubMed]
Variables | Orbital Complication | No Orbital Complication | p Value |
---|---|---|---|
(n = 15) | (n = 103) | ||
Age, years (mean ± SD) | 58.9 ± 21.1 | 52.6 ± 16.1 | 0.116 |
Gender | |||
Male, n | 6 (40.0%) | 33 (32.0%) | 0.565 |
Female, n | 9 (60.0%) | 70 (68.0%) | |
Site of sphenoid lesion | |||
Left, n | 5 (33.3%) | 47 (45.6%) | 0.149 |
Right, n | 8 (53.3%) | 53 (51.5%) | |
Single sphenoid sinus, n | 2 (13.3%) | 3 (2.9%) | |
Histopathology | |||
Fungus ball, n | 7 (46.7%) | 62 (60.2%) | 0.403 |
Non-fungus, n | 8 (53.3%) | 41 (39.8%) | |
Laboratory data | |||
WBC count, k per µl | 7.52 ± 1.79 | 6.83 ± 2.15 | 0.050 |
Underlying conditions | |||
Diabetes mellitus, n | 6 (40.0%) | 13 (12.6%) | 0.016 * |
Malignant neoplasms, n | 4 (26.7%) | 8 (7.8%) | 0.046 * |
Previous sphenoid sinus surgery, n | 2 (13.3%) | 19 (18.4%) | 1.000 |
Clinical presentations | |||
Headache and facial pain, n | 14 (93.3%) | 47 (45.6%) | <0.001 *** |
Rhinorrhea, n | 3 (20.0%) | 49 (47.6%) | 0.054 |
Purulent rhinorrhea, n | 3 (20.0%) | 25 (24.3%) | 1.000 |
Bloody rhinorrhea, n | 0 (0%) | 11 (10.7%) | 0.355 |
Nasal obstruction, n | 0 (0%) | 45 (43.7%) | <0.001 *** |
Post nasal dripping, n | 2 (13.3%) | 40 (38.8%) | 0.081 |
Hyposmia, n | 2 (13.3%) | 15 (14.6%) | 1.000 |
Foul odor smell, n | 0 (0%) | 9 (8.7%) | 0.601 |
Tinnitus, n | 0 (0%) | 2 (1.9%) | 1.000 |
Incidental found, n | 0 (0%) | 8 (7.8%) | 0.594 |
Features of CT image | |||
Total opacification, n | 7 (46.7%) | 49 (47.6%) | 1.000 |
Partial opacification, n | 8 (53.3%) | 54 (52.4%) | 1.000 |
Irregular surface, n | 3 (20.0%) | 34 (33.0%) | 0.385 |
Bony dehiscence, n | 10 (66.7%) | 30 (29.1%) | 0.007 ** |
Lateral wall sclerosis, n | 9 (60.0%) | 58 (56.3%) | 1.000 |
Intralesional hyperdensity, n | 4 (26.7%) | 38 (36.9%) | 0.569 |
Univariate Analysis | Multivariate Analysis | |||
---|---|---|---|---|
Variables | Odds Ratio (95% CI) | p Value | Odds Ratio (95% CI) | p Value |
Characteristics of patients | ||||
Age | 1.02 (0.99–1.06) | 0.179 | 1.00 (0.96–1.04) | 0.892 |
Diabetes mellitus | 4.62 (1.41–15.10) | 0.011 * | 5.27 (1.40–19.93) | 0.014 * |
Malignant neoplasms | 4.32 (1.12–16.71) | 0.034 * | 5.23 (1.17–23.31) | 0.030 * |
Female sex | 0.71 (0.23–2.15) | 0.542 | ||
WBC (x1000 per μL) | 1.14 (0.91–1.43) | 0.243 | ||
CT imaging features | ||||
Total opacification | 0.96(0.33–2.86) | 0.948 | ||
Partial opacification | 1.04 (0.35–3.07) | 0.948 | ||
Irregular surface | 0.51 (0.13–1.92) | 0.317 | ||
Bony dehiscence | 4.87 (1.53–15.44) | 0.007 ** | 5.21 (1.44–18.84) | 0.012 * |
Lateral wall sclerosis | 1.16 (0.39–3.51) | 0.788 | ||
Intralesional hyperdensity | 0.62 (0.19–2.09) | 0.443 |
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Chang, S.-Y.; Huang, C.-C.; Fan, Y.-H.; Wu, P.-W.; Lee, T.-J.; Chang, P.-H.; Huang, C.-C. Identifying the Risk Factors for Orbital Complications in Isolated Sphenoid Rhinosinusitis. Medicina 2024, 60, 128. https://doi.org/10.3390/medicina60010128
Chang S-Y, Huang C-C, Fan Y-H, Wu P-W, Lee T-J, Chang P-H, Huang C-C. Identifying the Risk Factors for Orbital Complications in Isolated Sphenoid Rhinosinusitis. Medicina. 2024; 60(1):128. https://doi.org/10.3390/medicina60010128
Chicago/Turabian StyleChang, Shiaw-Yu, Chi-Che Huang, Yu-Hsi Fan, Pei-Wen Wu, Ta-Jen Lee, Po-Hung Chang, and Chien-Chia Huang. 2024. "Identifying the Risk Factors for Orbital Complications in Isolated Sphenoid Rhinosinusitis" Medicina 60, no. 1: 128. https://doi.org/10.3390/medicina60010128