A Potential Radiomics–Clinical Model for Predicting Failure of Lymph Node Control after Definite Radiotherapy in Locally Advanced Head and Neck Cancer
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patient Information
2.2. CT Imaging and Radiotherapy
2.3. Radiomics Feature Extraction and Clinical Features
2.4. Radiomics Feature Selection
2.5. Statistical Test
3. Results
3.1. Survival and Failure of LN Control
3.2. Feature Selection
3.3. Performance Test
3.4. Feature Importance
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Category | Sub-Category | |
---|---|---|
Sex | Male: female | 58:11 |
Age (years) | Median (range) | 55 (26–84) |
Primary site | Nasopharynx:oropharynx:larynx:oral cavity: hypopharynx | 25:31:3:1:9 |
Virus status | EBV:HPV:negative:unknown | 21:17:11:20 |
Smoking | Never, ex-smoker, current smoker | 24:17:28 |
≤10:>10 (pack years) | 30:39 | |
Primary tumor | ||
T-stage | T1–2: T3–4 | 39:30 |
Size | ≤2:2.1–4:>4 (cm) | 15:35:19 |
Lymph node (LN) | ||
N-Stage | N1:N2–3 | 15: 54 |
Size | ≤3:3.1–6:>6 | 27:38:4 |
Multiplicity | ≤2:>2 (lymph node stations) | 29:40 |
Laterality | Unilateral: bilateral | 33:36 |
Extra capsular extension | No:yes | 29:40 |
Central necrosis | No:yes | 27:42 |
Total radiation dose | <70:≥70 (Gy) | 9:60 |
Concurrent chemotherapy | No:yes | 2:67 |
Regression of the largest LN size (long diameter CTmid/CTpre) | Median (range) | 0.762 (0.436–1.250) |
CTpre | CTmid | Clinical Parameters | CTpre Plus Clinical Parameters | CTmid Plus Clinical Parameters | |
---|---|---|---|---|---|
ACC | 0.681 ± 0.069 | 0.698 ± 0.089 | 0.726 ± 0.089 | 0.731 ± 0.100 | 0.790 ± 0.095 |
AUC | 0.521 ± 0.008 | 0.568 ± 0.093 | 0.593 ± 0.085 | 0.582 ± 0.088 | 0.662 ± 0.133 |
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Lee, S.; Park, S.; Rim, C.H.; Lee, Y.H.; Kwon, S.Y.; Oh, K.H.; Yoon, W.S. A Potential Radiomics–Clinical Model for Predicting Failure of Lymph Node Control after Definite Radiotherapy in Locally Advanced Head and Neck Cancer. Medicina 2024, 60, 92. https://doi.org/10.3390/medicina60010092
Lee S, Park S, Rim CH, Lee YH, Kwon SY, Oh KH, Yoon WS. A Potential Radiomics–Clinical Model for Predicting Failure of Lymph Node Control after Definite Radiotherapy in Locally Advanced Head and Neck Cancer. Medicina. 2024; 60(1):92. https://doi.org/10.3390/medicina60010092
Chicago/Turabian StyleLee, Seunghak, Sunmin Park, Chai Hong Rim, Young Hen Lee, Soon Young Kwon, Kyung Ho Oh, and Won Sup Yoon. 2024. "A Potential Radiomics–Clinical Model for Predicting Failure of Lymph Node Control after Definite Radiotherapy in Locally Advanced Head and Neck Cancer" Medicina 60, no. 1: 92. https://doi.org/10.3390/medicina60010092