The Neutrophil-to-Lymphocyte Ratio in Patients with Spinal Cord Injury: A Narrative Review Study
Abstract
:1. Introduction
Importance and Novelty
2. Materials and Methods
2.1. Object
2.2. Databases and Search Strategy
2.3. Inclusion and Exclusion Criteria
2.4. Study Outcomes
2.5. Spinal Cord Injury
2.6. The Neutrophils’ Role after SCI
2.7. The Lymphocytes’ Role after SCI
2.8. The Role of the Neutrophil-to-Lymphocyte Ratio in SCI
2.9. Pathophysiology of NLR Role Following SCI
3. Limitations
4. Conclusions
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Reference (Year) | Type of Study | Type of Trauma | Number of Subjects | Mean Age _ SD (y) or Range | Sex (M/F) | NL Ratio | Outcome | Additional Data Based on ROC-AUC |
---|---|---|---|---|---|---|---|---|
Zhao et al. (2020) [9] | Retrospective | Mild | 377 (human) | 46.05 ± 17.93 | 212/156 | 13.28 ± 11.46 | The NLR is an independent predictor of outcomes in the 6-month follow-up period in patients with acute cervical SCI | N/A |
Zhou et al. (2023) [49] | Retrospective | Mild, Moderate, Severe | 526 (human) | 52.2 ± 12.5 | 439/87 | N/A | The NLR showed higher diagnostic performance than the platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and systemic immune-inflammatory index | Sensitivity = 0.79, specificity = 0.57 |
Naseri Alavi et al. (2023) [50] | Retrospective | Mild, Moderate, Severe | 536 (human) | 40.93 ± 12.77 (min = 18, max = 64) | 399/137 | 8.43 ± 8.34 (min = 0.68, max = 70.69) | There was no significant relationship between neutrophil counts at admission and outcome following SCI; however, these counts decreased significantly over time. | N/A |
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Naseri Alavi, S.A.; Habibi, M.A.; Naseri Alavi, S.H.; Zamani, M.; Kobets, A.J. The Neutrophil-to-Lymphocyte Ratio in Patients with Spinal Cord Injury: A Narrative Review Study. Medicina 2024, 60, 1567. https://doi.org/10.3390/medicina60101567
Naseri Alavi SA, Habibi MA, Naseri Alavi SH, Zamani M, Kobets AJ. The Neutrophil-to-Lymphocyte Ratio in Patients with Spinal Cord Injury: A Narrative Review Study. Medicina. 2024; 60(10):1567. https://doi.org/10.3390/medicina60101567
Chicago/Turabian StyleNaseri Alavi, Seyed Ahmad, Mohammad Amin Habibi, Seyed Hamed Naseri Alavi, Mahsa Zamani, and Andrew J. Kobets. 2024. "The Neutrophil-to-Lymphocyte Ratio in Patients with Spinal Cord Injury: A Narrative Review Study" Medicina 60, no. 10: 1567. https://doi.org/10.3390/medicina60101567