Dose-Dependent Induction of Differential Seizure Phenotypes by Pilocarpine in Rats: Considerations for Translational Potential
Abstract
:1. Introduction
2. Materials and Methods
2.1. EEG Recordings
2.2. Statistical Analysis
3. Results
3.1. Behavioral Analysis
3.2. EEG Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Time (h) | Seizure Duration (s) | ||
---|---|---|---|
P100 | P200 | P300 | |
1 | 2.5 (2.1, 3.4) | 4.9 (2.3, 10.5) | 30.4 (20.1, 70.25) **# |
2 | 2.6 (1.9, 3.5) | 10.05 (7.6, 11.75) | 9.35 (5.975, 11.65) |
3 | 0 (0, 0) | 2.2 (1.6, 4.2) | 8 (5, 9.95) ** |
4 | 0 (0, 0) | 1.6 (1.2, 2.55) | 4.2 (2.725, 6.175) * |
Time (h) | The Number of Seizures (n) | ||
---|---|---|---|
P100 | P200 | P300 | |
1 | 9 (1.75, 12.5) | 22.5 (17.75, 28) | 26.5 (18, 30.25) |
2 | 0 (0, 3.75) | 8.5 (0, 10.75) | 20 (17.25, 22.75) |
3 | 0 (0, 0) | 2.5 (0, 5.75) | 9.5 (4.75, 13.25) |
4 | 0 (0, 0) | 0 (0, 1.5) | 8.5 (6.5, 10) |
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Vasović, D.; Stanojlović, O.; Hrnčić, D.; Šutulović, N.; Vesković, M.; Ristić, A.J.; Radunović, N.; Mladenović, D. Dose-Dependent Induction of Differential Seizure Phenotypes by Pilocarpine in Rats: Considerations for Translational Potential. Medicina 2024, 60, 1579. https://doi.org/10.3390/medicina60101579
Vasović D, Stanojlović O, Hrnčić D, Šutulović N, Vesković M, Ristić AJ, Radunović N, Mladenović D. Dose-Dependent Induction of Differential Seizure Phenotypes by Pilocarpine in Rats: Considerations for Translational Potential. Medicina. 2024; 60(10):1579. https://doi.org/10.3390/medicina60101579
Chicago/Turabian StyleVasović, Dolika, Olivera Stanojlović, Dragan Hrnčić, Nikola Šutulović, Milena Vesković, Aleksandar J. Ristić, Nebojša Radunović, and Dušan Mladenović. 2024. "Dose-Dependent Induction of Differential Seizure Phenotypes by Pilocarpine in Rats: Considerations for Translational Potential" Medicina 60, no. 10: 1579. https://doi.org/10.3390/medicina60101579