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Review

Endoscopic Ultrasound and Gastric Sub-Epithelial Lesions: Ultrasonographic Features, Tissue Acquisition Strategies, and Therapeutic Management

by
Marzia Varanese
1,2,
Marco Spadaccini
2,3,
Antonio Facciorusso
4,*,
Gianluca Franchellucci
2,3,
Matteo Colombo
2,
Marta Andreozzi
2,
Daryl Ramai
5,
Davide Massimi
2,
Roberto De Sire
2,
Ludovico Alfarone
2,
Antonio Capogreco
2,
Roberta Maselli
2,3,
Cesare Hassan
2,3,
Alessandro Fugazza
2,
Alessandro Repici
2,3 and
Silvia Carrara
2,3
1
Department of Surgery, Sapienza University of Rome, 00185 Rome, Italy
2
Division of Gastroenterology and Digestive Endoscopy, Humanitas Research Hospital—IRCCS, Rozzano, 20089 Milano, Italy
3
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milano, Italy
4
Gastroenterology Unit, Department of Medical Sciences, University of Foggia, 71100 Foggia, Italy
5
Gastroenterology and Hepatology, The University of Utah School of Medicine, Salt Lake City, UT 84113, USA
*
Author to whom correspondence should be addressed.
Medicina 2024, 60(10), 1695; https://doi.org/10.3390/medicina60101695
Submission received: 30 August 2024 / Revised: 7 October 2024 / Accepted: 12 October 2024 / Published: 15 October 2024
(This article belongs to the Section Gastroenterology & Hepatology)

Abstract

Background and objectives: Subepithelial lesions (SELs) of the gastrointestinal (GI) tract present a diagnostic challenge due to their heterogeneous nature and varied clinical manifestations. Usually, SELs are small and asymptomatic; generally discovered during routine endoscopy or radiological examinations. Currently, endoscopic ultrasound (EUS) is the best tool to characterize gastric SELs. Materials and methods: For this review, the research and the study selection were conducted using the PubMed database. Articles in English language were reviewed from August 2019 to July 2024. Results: This review aims to summarize the international literature to examine and illustrate the progress in the last five years of endosonographic diagnostics and treatment of gastric SELs. Conclusions: Endoscopic ultrasound is the preferred option for the diagnosis of sub-epithelial lesions. In most of the cases, EUS-guided tissue sampling is mandatory; however, ancillary techniques (elastography, CEH-EUS, AI) may help in both diagnosis and prognostic assessment.
Keywords: gastric subepithelial lesions; endoscopic ultrasound; fine needle biopsy; gastrointestinal stromal tumors; Fine needle aspiration; artificial intelligence gastric subepithelial lesions; endoscopic ultrasound; fine needle biopsy; gastrointestinal stromal tumors; Fine needle aspiration; artificial intelligence

Share and Cite

MDPI and ACS Style

Varanese, M.; Spadaccini, M.; Facciorusso, A.; Franchellucci, G.; Colombo, M.; Andreozzi, M.; Ramai, D.; Massimi, D.; De Sire, R.; Alfarone, L.; et al. Endoscopic Ultrasound and Gastric Sub-Epithelial Lesions: Ultrasonographic Features, Tissue Acquisition Strategies, and Therapeutic Management. Medicina 2024, 60, 1695. https://doi.org/10.3390/medicina60101695

AMA Style

Varanese M, Spadaccini M, Facciorusso A, Franchellucci G, Colombo M, Andreozzi M, Ramai D, Massimi D, De Sire R, Alfarone L, et al. Endoscopic Ultrasound and Gastric Sub-Epithelial Lesions: Ultrasonographic Features, Tissue Acquisition Strategies, and Therapeutic Management. Medicina. 2024; 60(10):1695. https://doi.org/10.3390/medicina60101695

Chicago/Turabian Style

Varanese, Marzia, Marco Spadaccini, Antonio Facciorusso, Gianluca Franchellucci, Matteo Colombo, Marta Andreozzi, Daryl Ramai, Davide Massimi, Roberto De Sire, Ludovico Alfarone, and et al. 2024. "Endoscopic Ultrasound and Gastric Sub-Epithelial Lesions: Ultrasonographic Features, Tissue Acquisition Strategies, and Therapeutic Management" Medicina 60, no. 10: 1695. https://doi.org/10.3390/medicina60101695

APA Style

Varanese, M., Spadaccini, M., Facciorusso, A., Franchellucci, G., Colombo, M., Andreozzi, M., Ramai, D., Massimi, D., De Sire, R., Alfarone, L., Capogreco, A., Maselli, R., Hassan, C., Fugazza, A., Repici, A., & Carrara, S. (2024). Endoscopic Ultrasound and Gastric Sub-Epithelial Lesions: Ultrasonographic Features, Tissue Acquisition Strategies, and Therapeutic Management. Medicina, 60(10), 1695. https://doi.org/10.3390/medicina60101695

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