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Article

Factors Influencing the Clinical Course of Bullous Pemphigoid among Geriatric Patients: A Pilot Study

by
Paula Mazan
1,*,
Aleksandra Lesiak
1,
Igor Bednarski
2,
Dorota Sobolewska-Sztychny
1,
Marcin Noweta
1 and
Joanna Narbutt
1,*
1
Department of Dermatology, Pediatric Dermatology and Oncology, Medical University of Lodz, 90-419 Lodz, Poland
2
Department of Neurology and Stroke, Medical University of Lodz, 90-419 Lodz, Poland
*
Authors to whom correspondence should be addressed.
Medicina 2024, 60(10), 1701; https://doi.org/10.3390/medicina60101701
Submission received: 25 July 2024 / Revised: 6 October 2024 / Accepted: 14 October 2024 / Published: 16 October 2024
(This article belongs to the Section Dermatology)
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Abstract

Background and Objectives: Bullous pemphigoid (BP) is the most common autoimmune blistering disease affecting mainly elderly patients. Still, little is known about the pathogenesis of pruritus in BP or the factors that affect the clinical course of the disease. This study aimed to evaluate the factors influencing the clinical course of BP among older patients. Materials and Methods: A retrospective analysis of medical records of 55 patients with BP hospitalized in the dermatology department in 2015–2021 was conducted. The study focused on preliminary diagnosis, medical history, clinical examination (characteristics and location of cutaneous changes), laboratory investigation, and direct and indirect immunofluorescence. Results: Analysis of laboratory results in combination with the clinical course of BP showed that red blood cell count, hemoglobin, and hematocrit values were negatively associated with a risk of erosions and erythema, while MCHC values were positively correlated with a risk of associated pruritus. A correlation was found between neurological diseases and an increased risk of erosions. Conclusions: We have shown that age and neurological conditions, including stroke, affect the clinical course of BP. Further studies on a larger group of patients should be conducted to investigate the different factors affecting the clinical aspect of BP and to understand the relationship between them.
Keywords: bullous pemphigoid; elderly; pruritus; neurological diseases; comorbidities bullous pemphigoid; elderly; pruritus; neurological diseases; comorbidities

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MDPI and ACS Style

Mazan, P.; Lesiak, A.; Bednarski, I.; Sobolewska-Sztychny, D.; Noweta, M.; Narbutt, J. Factors Influencing the Clinical Course of Bullous Pemphigoid among Geriatric Patients: A Pilot Study. Medicina 2024, 60, 1701. https://doi.org/10.3390/medicina60101701

AMA Style

Mazan P, Lesiak A, Bednarski I, Sobolewska-Sztychny D, Noweta M, Narbutt J. Factors Influencing the Clinical Course of Bullous Pemphigoid among Geriatric Patients: A Pilot Study. Medicina. 2024; 60(10):1701. https://doi.org/10.3390/medicina60101701

Chicago/Turabian Style

Mazan, Paula, Aleksandra Lesiak, Igor Bednarski, Dorota Sobolewska-Sztychny, Marcin Noweta, and Joanna Narbutt. 2024. "Factors Influencing the Clinical Course of Bullous Pemphigoid among Geriatric Patients: A Pilot Study" Medicina 60, no. 10: 1701. https://doi.org/10.3390/medicina60101701

APA Style

Mazan, P., Lesiak, A., Bednarski, I., Sobolewska-Sztychny, D., Noweta, M., & Narbutt, J. (2024). Factors Influencing the Clinical Course of Bullous Pemphigoid among Geriatric Patients: A Pilot Study. Medicina, 60(10), 1701. https://doi.org/10.3390/medicina60101701

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