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10.3390/medicina60020286
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Systematic Review

One-Year Outcomes of CGuard Double Mesh Stent in Carotid Artery Disease: A Systematic Review and Meta-Analysis

by
Konstantinos Tigkiropoulos
1,*,†,
Spyridon Nikas
2,†,
Abatzis-Papadopoulos Manolis
1,
Katerina Sidiropoulou
1,
Kyriakos Stavridis
1,
Dimitrios Karamanos
1,
Ioannis Lazaridis
1 and
Nikolaos Saratzis
1
1
Division of Vascular Surgery, 1st Surgical Department, Faculty of Health Sciences, Papageorgiou General Hospital, Aristotle University, 56403 Thessaloniki, Greece
2
Department of Radiology, Papageorgiou General Hospital, 56403 Thessaloniki, Greece
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Medicina 2024, 60(2), 286; https://doi.org/10.3390/medicina60020286
Submission received: 9 January 2024 / Revised: 2 February 2024 / Accepted: 5 February 2024 / Published: 8 February 2024
(This article belongs to the Special Issue The Challenges and Prospects in Clinical Cardiology and Angiology)
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Abstract

Background: Prospective single and multicenter studies have shown improved outcomes of patients who underwent carotid artery stenting with the novel CGuard dual-layer mesh stent at 1 year. Objectives: The aim of this study is to conduct a systematic review and meta-analysis of all published studies to assess 1-year efficacy and outcomes of CGuard in patients with carotid stenting. Methods: A systematic search was performed. All studies enrolling at least 20 patients were included in our analysis. The primary endpoints were death (all-cause, cardiovascular and ipsilateral stroke-related death) and stroke rate at 1 year. The secondary endpoint was in-stent restenosis at 1 year. Results: The final analysis included 1709 patients. The one-year all-cause mortality rate was 2.97% (39/1699, 95% CI: 1.26–6.86%, I2 = 67%, t2 = 0.3442, p < 0.01), cardiovascular-related death was 0.92% (10/1616, 95% CI: 0.35–2.39%, I2 = 34%, t2 = 0.2302, p = 0.18), and ipsilateral stroke-related death was 0.3% (1/1649, 95% CI: 0.1–0.87%, I2 = 0%, t2 = 0, p = 0.69). The one-year ipsilateral stroke rate was 1.21% (16/1649, 95% CI: 0.58–2.5%, I2 = 28%, t2 = 0.1433, p = 0.23), transient ischemic attacks (TIAs) rate was 1.78% (19/1149, 95% CI: 1.11–2.84%, I2 = 0%, t2 = 0, p = 0.69), and total composite 1-year stroke/TIA rate was 2.97% (32/1149, 95% CI: 1.84–4.77%, I2 = 0%, t2 = 0, p = 0.41). The in-stent restenosis rate at 1 year was 1.06% (13/1653, 95% CI: 0.48–2.34%, I2 = 28%, t2 = 0.2308, p = 0.22). Conclusions: This meta-analysis shows that CAS with CGuard is safe with minimal neurological adverse events and in-stent restenosis rate at 1 year.
Keywords: CGuard; carotid artery stenting; carotid artery disease; dual layer mesh stents; systematic review and meta-analysis CGuard; carotid artery stenting; carotid artery disease; dual layer mesh stents; systematic review and meta-analysis

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MDPI and ACS Style

Tigkiropoulos, K.; Nikas, S.; Manolis, A.-P.; Sidiropoulou, K.; Stavridis, K.; Karamanos, D.; Lazaridis, I.; Saratzis, N. One-Year Outcomes of CGuard Double Mesh Stent in Carotid Artery Disease: A Systematic Review and Meta-Analysis. Medicina 2024, 60, 286. https://doi.org/10.3390/medicina60020286

AMA Style

Tigkiropoulos K, Nikas S, Manolis A-P, Sidiropoulou K, Stavridis K, Karamanos D, Lazaridis I, Saratzis N. One-Year Outcomes of CGuard Double Mesh Stent in Carotid Artery Disease: A Systematic Review and Meta-Analysis. Medicina. 2024; 60(2):286. https://doi.org/10.3390/medicina60020286

Chicago/Turabian Style

Tigkiropoulos, Konstantinos, Spyridon Nikas, Abatzis-Papadopoulos Manolis, Katerina Sidiropoulou, Kyriakos Stavridis, Dimitrios Karamanos, Ioannis Lazaridis, and Nikolaos Saratzis. 2024. "One-Year Outcomes of CGuard Double Mesh Stent in Carotid Artery Disease: A Systematic Review and Meta-Analysis" Medicina 60, no. 2: 286. https://doi.org/10.3390/medicina60020286

APA Style

Tigkiropoulos, K., Nikas, S., Manolis, A.-P., Sidiropoulou, K., Stavridis, K., Karamanos, D., Lazaridis, I., & Saratzis, N. (2024). One-Year Outcomes of CGuard Double Mesh Stent in Carotid Artery Disease: A Systematic Review and Meta-Analysis. Medicina, 60(2), 286. https://doi.org/10.3390/medicina60020286

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