Local Oxygen-Based Therapy (blue®m) for Treatment of Peri-Implant Disease: Clinical Case Presentation and Review of Literature about Conventional Local Adjunct Therapies
Abstract
:1. Introduction
2. Clinical Case Presentation of Peri-Implant Mucositis
3. Clinical Cases Presentation of Peri-Implantitis
3.1. Case Report 1
3.2. Case Report 2
4. Systematic Review of Literature—Methodology and Results
5. Discussion
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Author | Nature of Non-Surgical Therapy | Local Adjunct Therapy | Compared with | Conclusions |
---|---|---|---|---|
Porras et al. [27] | Scaling with plastic scaler + mechanical cleansing with rubber cup and polishing paste | Chlorhexidine (0.12%) gel + rinse (Test) | Placebo (Control) | After 3 months follow-up; use of chlorhexidine (0.12%) gel + rinse as a local adjunct to mechanical therapy for peri-implant mucositis resulted in resolution of inflammation and a significant reduction in PPD. |
Heitz-Mayfield et al. [28] | Scaling with plastic scaler + mechanical cleansing with rubber cup and polishing paste | Chlorhexidine (0.5%) gel to be brushed around the implant; twice a day for 4 weeks (Test) | Placebo gel (Control) | After 3 months follow-up; use of chlorhexidine (0.5%) gel as a local adjunct to mechanical therapy did not significantly enhance clinical outcomes in peri-implant mucositis. Implants with restoration margins placed supra-gingivally showed better treatment response than implants with sub-mucosal restoration margins. |
De Siena et al. [18] | Professional oral prophylaxis administered by dental hygienist | Chlorhexidine (0.2%) mouthwash 10 mL—rinsed twice a day for 10 days | Chlorhexidine (1%) gel 1 mL placed sub-mucosally twice a day for 10 days | After 3 months follow-up; use of chlorhexidine rinse (0.2%) or gel (1%) as a local adjunct to treat peri-implant mucositis gave better clinical outcomes. Nevertheless; there was no difference in outcomes between the two formulations. |
Pulcini et al. [12] | Ultrasonic scaling with plastic tip + erythritol-based air powder polishing | Chlorhexidine (0.03%) + CPC (0.05%) mouthwash (Test) | Mouthwash without chlorhexidine or CPC (Control) | After 12 months follow-up; use of chlorhexidine (0.03%) + CPC (0.05%) mouthwash as a local adjunct in peri-implant mucositis resulted in better clinical outcomes than with mouthwash without the above active ingredients. However, the formulation did not result in complete resolution of peri-implant disease. |
Iorio-Siciliano et al. [29] | Ultrasonic scaling with plastic tips + mechanical cleansing with rubber cup and polishing paste | Amino acid buffered sodium hypochlorite gel—applied 5 times in the peri-implant tissues immediately after non-surgical therapy (Test) | Placebo gel—applied in the same way as test group (Control) | After 6 months follow-up; use of sodium hypochlorite gel as a local adjunct to non-surgical therapy of peri-implant mucositis resulted in a significant reduction in PPD and number of implants with BOP, which was better than that with placebo gel, but not significantly. Neither modality resulted in complete peri-implant disease resolution. |
Philip et al. [20] | Ultrasonic scaling with plastic tips + mechanical cleansing with rubber cup and polishing paste | Delmopinol hydrochloride (0.2%) mouthwash twice daily until follow-up (Test) | Chlorhexidine (0.2%) mouthwash twice daily until follow-up (Positive Control)/Placebo mouthwash twice daily until follow-up (Negative Control) | After 3 months follow-up; use of delmopinol hydrochloride mouthwash as an adjunct to non-surgical therapy of peri-implant mucositis resulted in a significant improvement in clinical parameters, than with the use of chlorhexidine mouthwash. There was 87% disease resolution among patients who used delmopinol mouthwash; in comparison to 60% and 71% in those who used chlorhexidine and placebo mouthwashes, respectively. |
Alqahtani et al. [17] | Ultrasonic scaling with plastic tips + mechanical cleansing with rubber cup and polishing paste | Probiotic lozenge containing Lactobacillus reuteri; chewed orally twice a day after brushing; for 21 days (Test) | Amoxycillin 500 mg administered orally; three times a day for 7 days (Positive control)/Non-surgical therapy only (Negative control) | After 3 months follow-up; use of probiotic therapy as a topical adjunct to non-surgical therapy of peri-implant mucositis was more effective than adjunct antibiotic therapy in terms of significantly improved clinical outcomes. |
Santana et al. [8] | Ultrasonic scaling with Teflon-coated tips + mechanical cleansing with rubber cup and polishing paste | Topically applied carboxymethyl cellulose gel containing a probiotic formulation of Bifidobacterium lactis, Lactobacillus rhamnosus, and Lactobacillus paracasei (Test) | Non-surgical therapy only (Control) | After 6 months follow-up; use of probiotic therapy as a topical adjunct to non-surgical therapy of peri-implant mucositis in edentulous patients resulted in significantly improved clinical outcomes and immunological benefits. |
Author | Nature of Non-Surgical Therapy | Local Adjunct Therapy | Compared with | Conclusions |
---|---|---|---|---|
Mombelli et al. [30] | Scaling with plastic scaler + mechanical cleansing with rubber cup and polishing paste | Tetracycline fibers were placed in pocket for 10 days | - | After 6 months follow-up; use of tetracycline as a local adjunct to non-surgical therapy of peri-implantitis resulted in a significant improvement in clinical parameters and reduction in microbial colonies. |
Renvert et al. [16] | Scaling with plastic scaler + mechanical cleansing with rubber cup and polishing paste | Minocycline microspheres (1 mg) placed sub-mucosally (Test) | Chlorhexidine (1%) gel 1 mL placed sub-mucosally (Control) | After 12 months follow-up; use of minocycline as a local adjunct to mechanical therapy for peri-implantitis resulted in a greater sustained reduction in PPD over 12 months, than with the use of chlorhexidine. |
Levin et al. [31] | Ultrasonic scaling and surface debridement with specialized instruments | Water jet irrigation with chlorhexidine gel 5 mL (Test) | Only water jet irrigation (Control) | After 3 months follow-up; use of local chlorhexidine gel delivered through water jet irrigation as an adjunct to mechanical therapy for peri-implantitis significantly decreased BOP and PPD, than when using water jet alone. There was no significant improvement in RBL in both groups. |
Roos-Jansåker et al. [6] | Ultrasonic scaling with sub-mucosal debridement using piezo-ceramic scaler tips | Sub-mucosally administered chloramine to cover all implant surfaces (Test) | Only scaling and debridement (Control) | After 3 months follow-up; use of local chloramine as an adjunct to non-surgical therapy of peri-implantitis was only as effective as conventional treatment. Irrespective of the use of chloramine or not, there was a significant improvement in clinical outcomes. |
Kashefimehr et al. [9] | Sub-gingival scaling with plastic tips + air polishing with glycine-based powder | EMD administered sub-mucosally; 2 weeks after non-surgical therapy (Test) | Non-surgical therapy only (Control) | After 3 months follow-up; use of EMD as a local adjunct to non-surgical mechanical therapy for peri-implantitis resulted in a significant improvement in clinical outcomes, in comparison to mechanical debridement alone. There was no complete disease resolution either with or without EMD. |
Mensi et al. [11] | Ultrasonic scaling + supra- and sub-gingival erythritol-based air powder polishing | Doxycycline administered supra- and sub-gingivally (one week after non-surgical therapy + additional peri-implant doxycycline application one week later) | - | After 12 months follow-up; use of multiple anti-infective adjunct therapy with doxycycline and eythritol air polishing along with mechanical therapy for peri-implantitis resulted in a significant improvement in clinical parameters. |
Laleman et al. [10] | Ultrasonic scaling with specialized tips + sub-gingival debridement with titanium curettes + Air polishing | Dual strain probiotic Lactobacillus reuteri drops in peri-implant area after non-surgical therapy + lozenges (1–2 per day) containing the above probiotic strains for 12 weeks (Test) | Placebo drops and lozenges without probiotic bacteria (Control) | After 6 months follow-up; use of dual strain probiotic Lactobacillus reuteri as an adjunct for non-surgical therapy of peri-implantitis showed no clinically discernible benefits. |
Mayer et al. [7] | Ultrasonic scaling with specialized tips + sub-gingival debridement with Teflon-coated curettes | Amino acid buffered sodium hypochlorite gel—applied 3 times in the peri-implant tissues immediately after non-surgical therapy + 1 mg minocycline (Test) | Non-surgical therapy only (Control) | After 12 months follow-up; use of sodium hypochlorite gel with minocycline as a local adjunct to non-surgical therapy of peri-implantitis resulted in a significant reduction in inflammation and better connective tissue reattachment. This formulation provided a local antiseptic and anti-inflammatory effect. |
Machtei et al. [32] | Supra-gingival ultrasonic scaling + sub-gingival implant surface debridement with specialized tips | Sub-gingival chlorhexidine chips applied bi-weekly for 12 weeks (Test) | Non-surgical therapy only (Control) | After 6 months follow-up; use of chlorhexidine chips as a local adjunct to non-surgical therapy of peri-implantitis resulted in a significant improvement in clinical parameters (PPD and CAL). |
Park et al. [33] | Ultrasonic scaling + sub-gingival mechanical debridement with specialized tips | Metronidazole + Minocycline ointment administered locally (Test 1)/Minocycline ointment administered locally (Test 2) | Non-surgical therapy only (Control) | After 3 months follow-up; use of either a combination of metronidazole and minocycline or minocycline alone as a local adjunct to non-surgical therapy of peri-implantitis resulted in significantly improved clinical treatment outcomes. However, in deep pockets (≥8 mm), the use of metronidazole and minocycline resulted in greater PPD reduction. |
Alhumaidan et al. [15] | Ultrasonic scaling + sub-gingival mechanical debridement with specialized tips | Minocycline microspheres (1 mg) placed sub-gingivally (Test) | Non-surgical therapy only (Control) | After 6 months follow-up; use of minocycline administered sub-gingivally as a single-use adjunct to non-surgical therapy of peri-implantitis resulted in significantly improved clinical outcomes than with the use of non-surgical therapy alone. It may be assumed that only topical application of minocycline in peri-implantitis might be as effective as non-surgical therapy alone. |
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Shaheen, M.Y.; Abas, I.; Basudan, A.M.; Alghamdi, H.S. Local Oxygen-Based Therapy (blue®m) for Treatment of Peri-Implant Disease: Clinical Case Presentation and Review of Literature about Conventional Local Adjunct Therapies. Medicina 2024, 60, 447. https://doi.org/10.3390/medicina60030447
Shaheen MY, Abas I, Basudan AM, Alghamdi HS. Local Oxygen-Based Therapy (blue®m) for Treatment of Peri-Implant Disease: Clinical Case Presentation and Review of Literature about Conventional Local Adjunct Therapies. Medicina. 2024; 60(3):447. https://doi.org/10.3390/medicina60030447
Chicago/Turabian StyleShaheen, Marwa Y., Irfan Abas, Amani M. Basudan, and Hamdan S. Alghamdi. 2024. "Local Oxygen-Based Therapy (blue®m) for Treatment of Peri-Implant Disease: Clinical Case Presentation and Review of Literature about Conventional Local Adjunct Therapies" Medicina 60, no. 3: 447. https://doi.org/10.3390/medicina60030447