The Effect of Cerium Oxide (CeO2) on Ischemia-Reperfusion Injury in Skeletal Muscle in Mice with Streptozocin-Induced Diabetes
Abstract
:1. Introduction
2. Materials and Methods
2.1. Histopathologic Assessment
2.2. Biochemical Assessment
2.2.1. Measurements of TAS/TOS
TAS/TOS Measurement
Oxidative Stress Index
2.3. Paraoxanase (PON) Measurement
2.4. Statistical Analysis
3. Results
3.1. Histopathologic Findings
3.2. Biochemical Findings
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Group C (n = 6) | Group D (n = 8) | Group DCO (n = 8) | Group DIR (n = 8) | Group DIR-CO (n = 8) | p ** | |
---|---|---|---|---|---|---|
Disorganization and degeneration of muscle cells | 0.00 (0.00–1.00) | 1.00 (0.00–2.00) | 1.00 (1.00–2.00) * | 3.00 (3.–3.00) *,†,‡ | 2.00 (1.00–2.00) *,†,§ | <0.001 |
Inflammatory cell infiltration | 0.00 (0.00–0.00) | 0.50 (0.00–1.00) * | 1.00 (1.00–1.00) * | 1.50 (1.00–2.00) *,†,‡ | 1.00 (1.00–1.00) *,§ | <0.001 |
Total injury score | 0.00 (0.00–1.00) | 1.00 (0.00–3.00) * | 2.00 (2.00–3.00) * | 4.00 (4.00–5.00) *,†,‡ | 3.00 (2.00–3.00) *,†,§ | <0.001 |
Group C (n = 6) | Group D (n = 8) | Group DCO (n = 8) | Group DIR (n = 8) | Group DIR-CO (n = 8) | p ** | |
---|---|---|---|---|---|---|
TAS (nmol/mL) | 1.46 ± 0.47 | 1.09 ± 0.11 * | 1.12 ± 0.22 * | 0.81 ± 0.11 *,†,‡ | 1.03 ± 0.06 * | 0.001 |
TOS (IU/mg·pro) | 5.49 ± 2.65 | 13.99 ± 1.74 * | 13.17 ± 3.44 * | 28.58 ± 8.03 *,†,‡ | 16.20 ± 5.13 *,§ | <0.001 |
OSI | 3.80 ± 1.18 | 12.93 ± 1.40 * | 11.94 ± 3.45 * | 36.09 ± 12.34 *,†,‡ | 15.87 ± 5.22 *,§ | <0.001 |
PON (IU/mg·pro) | 295.57 ± 57.28 | 355.86 ± 29.48 | 340.38 ± 57.27 | 455.86 ± 77.87 *,†,‡ | 362.57 ± 45.32 *,§ | <0.001 |
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Özer, A.; Şengel, N.; Küçük, A.; Yığman, Z.; Özdemir, Ç.; Kılıç, Y.; Dursun, A.D.; Bostancı, H.; Kip, G.; Arslan, M. The Effect of Cerium Oxide (CeO2) on Ischemia-Reperfusion Injury in Skeletal Muscle in Mice with Streptozocin-Induced Diabetes. Medicina 2024, 60, 752. https://doi.org/10.3390/medicina60050752
Özer A, Şengel N, Küçük A, Yığman Z, Özdemir Ç, Kılıç Y, Dursun AD, Bostancı H, Kip G, Arslan M. The Effect of Cerium Oxide (CeO2) on Ischemia-Reperfusion Injury in Skeletal Muscle in Mice with Streptozocin-Induced Diabetes. Medicina. 2024; 60(5):752. https://doi.org/10.3390/medicina60050752
Chicago/Turabian StyleÖzer, Abdullah, Necmiye Şengel, Ayşegül Küçük, Zeynep Yığman, Çağrı Özdemir, Yiğit Kılıç, Ali Doğan Dursun, Hasan Bostancı, Gülay Kip, and Mustafa Arslan. 2024. "The Effect of Cerium Oxide (CeO2) on Ischemia-Reperfusion Injury in Skeletal Muscle in Mice with Streptozocin-Induced Diabetes" Medicina 60, no. 5: 752. https://doi.org/10.3390/medicina60050752