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Volume 60
Issue 8
10.3390/medicina60081204
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

From Lipid Signatures to Cellular Responses: Unraveling the Complexity of Melanoma and Furthering Its Diagnosis and Treatment

by
Elisa Díaz-Grijuela
1,
Agustín Hernández
1,
Claudia Caballero
1,
Roberto Fernandez
2,
Raquel Urtasun
3,
Marina Gulak
4,
Egoitz Astigarraga
1,2,
Miguel Barajas
3 and
Gabriel Barreda-Gómez
1,2,*
1
Betternostics SL, 31110 Noáin, Spain
2
IMG Pharma Biotech, Research and Development Division, 48170 Zamudio, Spain
3
Biochemistry Area, Department of Health Science, Universidad Pública de Navarra, 31006 Pamplona, Spain
4
Cruz Roja Hospital, 48013 Bilbao, Spain
*
Author to whom correspondence should be addressed.
Medicina 2024, 60(8), 1204; https://doi.org/10.3390/medicina60081204
Submission received: 1 July 2024 / Revised: 19 July 2024 / Accepted: 22 July 2024 / Published: 25 July 2024
(This article belongs to the Section Oncology)
Versions Notes

Abstract

Recent advancements in mass spectrometry have significantly enhanced our understanding of complex lipid profiles, opening new avenues for oncological diagnostics. This review highlights the importance of lipidomics in the comprehension of certain metabolic pathways and its potential for the detection and characterization of various cancers, in particular melanoma. Through detailed case studies, we demonstrate how lipidomic analysis has led to significant breakthroughs in the identification and understanding of cancer types and its potential for detecting unique biomarkers that are instrumental in its diagnosis. Additionally, this review addresses the technical challenges and future perspectives of these methodologies, including their potential expansion and refinement for clinical applications. The discussion underscores the critical role of lipidomic profiling in advancing cancer diagnostics, proposing a new paradigm in how we approach this devastating disease, with particular emphasis on its application in comparative oncology.
Keywords: melanoma; comparative oncology; liquid biopsy; mass spectrometry; lipidomics melanoma; comparative oncology; liquid biopsy; mass spectrometry; lipidomics

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MDPI and ACS Style

Díaz-Grijuela, E.; Hernández, A.; Caballero, C.; Fernandez, R.; Urtasun, R.; Gulak, M.; Astigarraga, E.; Barajas, M.; Barreda-Gómez, G. From Lipid Signatures to Cellular Responses: Unraveling the Complexity of Melanoma and Furthering Its Diagnosis and Treatment. Medicina 2024, 60, 1204. https://doi.org/10.3390/medicina60081204

AMA Style

Díaz-Grijuela E, Hernández A, Caballero C, Fernandez R, Urtasun R, Gulak M, Astigarraga E, Barajas M, Barreda-Gómez G. From Lipid Signatures to Cellular Responses: Unraveling the Complexity of Melanoma and Furthering Its Diagnosis and Treatment. Medicina. 2024; 60(8):1204. https://doi.org/10.3390/medicina60081204

Chicago/Turabian Style

Díaz-Grijuela, Elisa, Agustín Hernández, Claudia Caballero, Roberto Fernandez, Raquel Urtasun, Marina Gulak, Egoitz Astigarraga, Miguel Barajas, and Gabriel Barreda-Gómez. 2024. "From Lipid Signatures to Cellular Responses: Unraveling the Complexity of Melanoma and Furthering Its Diagnosis and Treatment" Medicina 60, no. 8: 1204. https://doi.org/10.3390/medicina60081204

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