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Open AccessBrief Report
Exploring the Non-Invasive Approaches to Carpal Tunnel Syndrome in Routine Clinical Practice: A Focus on the Role of Acetylcholinesterase Inhibitors
by
Ojārs Rubens
Ojārs Rubens 1,
Solvita Bērziņa
Solvita Bērziņa 1,
Anda Rozenbaha
Anda Rozenbaha 2,
Guna Dansone
Guna Dansone 3 and
Yulia Troshina
Yulia Troshina 3,*
1
Pauls Stradins Clinical University Hospital, 1002 Riga, Latvia
2
Neuro LLC., 1039 Riga, Latvia
3
Medical and Clinical Research Department, JSC Olpha, LV-2114 Olaine, Latvia
*
Author to whom correspondence should be addressed.
Medicina 2024, 60(8), 1219; https://doi.org/10.3390/medicina60081219 (registering DOI)
Submission received: 25 June 2024
/
Revised: 18 July 2024
/
Accepted: 24 July 2024
/
Published: 27 July 2024
Abstract
The prevalence of N. medianus compression neuropathies remains high in clinical practice. The objective was to evaluate modalities of conservative treatments for carpal tunnel syndrome (CTS) focusing on the role of acetylcholinesterase inhibitors. This observational study involved 51 adult outpatients diagnosed with CTS. Patients were observed during routine clinical protocols and we compared two groups of 25 and 26 individuals, with the first group receiving basic therapy for CTS and 20 mg of ipidacrine (Neiromidin®) two or three times a day per os, while the second group received only basic therapy. The condition of all patients was assessed twice, with at least a one-month interval. The parameters evaluated included the Boston Carpal Tunnel Questionnaire (BCTQ); the Disabilities of the Arm, Shoulder, and Hand scale (DASH); and pain intensity on the Numeric Rating Scale (NRS). The mean reduction in DASH score was 12.3 (SD 7.7) in Group 1 and 7.1 (SD 6.3) in Group 2 (p < 0.01). Also, other scores showed statistically significant differences between the two groups: −2.3 vs. −1.0 for NRS, −0.89 vs. −0.44 for SSS, and −0.68 vs. −0.31 for FSS, respectively (p < 0.01). Moreover, these findings correlated positively with the global improvement (CGI-I) between the groups. The addition of ipidacrine to basic therapy led to improved recovery in patients with CTSs of varying severity.
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MDPI and ACS Style
Rubens, O.; Bērziņa, S.; Rozenbaha, A.; Dansone, G.; Troshina, Y.
Exploring the Non-Invasive Approaches to Carpal Tunnel Syndrome in Routine Clinical Practice: A Focus on the Role of Acetylcholinesterase Inhibitors. Medicina 2024, 60, 1219.
https://doi.org/10.3390/medicina60081219
AMA Style
Rubens O, Bērziņa S, Rozenbaha A, Dansone G, Troshina Y.
Exploring the Non-Invasive Approaches to Carpal Tunnel Syndrome in Routine Clinical Practice: A Focus on the Role of Acetylcholinesterase Inhibitors. Medicina. 2024; 60(8):1219.
https://doi.org/10.3390/medicina60081219
Chicago/Turabian Style
Rubens, Ojārs, Solvita Bērziņa, Anda Rozenbaha, Guna Dansone, and Yulia Troshina.
2024. "Exploring the Non-Invasive Approaches to Carpal Tunnel Syndrome in Routine Clinical Practice: A Focus on the Role of Acetylcholinesterase Inhibitors" Medicina 60, no. 8: 1219.
https://doi.org/10.3390/medicina60081219
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