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Open AccessArticle
Mangiferin Induces Post-Implant Osteointegration in Male Diabetic Rats
by
Bünyamin Ongan
Bünyamin Ongan 1,
Ömer Ekici
Ömer Ekici 1,
Gökhan Sadi
Gökhan Sadi 2,
Esra Aslan
Esra Aslan 3 and
Mehmet Bilgehan Pektaş
Mehmet Bilgehan Pektaş 4,*
1
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Afyonkarahisar Health Sciences University, 03200 Afyonkarahisar, Türkiye
2
Department of Biology, K.O. Science Faculty, Karamanoglu Mehmetbey University, 70100 Karaman, Türkiye
3
Department of Histology and Embryology, Faculty of Medicine, Afyonkarahisar Health Sciences University, 03200 Afyonkarahisar, Türkiye
4
Department of Medical Pharmacology, Faculty of Medicine, Afyonkarahisar Health Sciences University, 03200 Afyonkarahisar, Türkiye
*
Author to whom correspondence should be addressed.
Medicina 2024, 60(8), 1224; https://doi.org/10.3390/medicina60081224 (registering DOI)
Submission received: 10 June 2024
/
Revised: 22 July 2024
/
Accepted: 25 July 2024
/
Published: 28 July 2024
Abstract
Background and Objectives: Hyperglycemia is known to undermine the osteointegration process of implants. In this study, the effects of mangiferin (MF) on the post-implant osteointegration process in a type-II diabetes model were investigated molecularly and morphologically. Materials and Methods: Sprague Dawley male rats were divided into three groups: control, diabetes, and diabetes + MF. All animals were implanted in their tibia bones on day 0. At the end of the 3-month experimental period, the animals’ blood and the implant area were isolated. Biochemical measurements were performed on blood samples and micro-CT, qRT-PCR, histological, and immunohistochemical measurements were performed on tibia samples. Results: MF significantly improved the increased glucose, triglyceride-VLDL levels, and liver enzymes due to diabetes. By administering MF to diabetic rats, the osteointegration percentage and bone volume increased while porosity decreased. DKK1 and BMP-2 mRNA expressions and OPN, OCN, and OSN mRNA–protein expressions increased by MF administration in diabetic rats. Additionally, while osteoblast and osteoid surface areas increased with MF, osteoclast and eroded surface areas decreased. Conclusions: The findings of our study indicate that MF will be beneficial to the bone-repairing process and osteointegration, which are impaired by type-II diabetes.
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MDPI and ACS Style
Ongan, B.; Ekici, Ö.; Sadi, G.; Aslan, E.; Pektaş, M.B.
Mangiferin Induces Post-Implant Osteointegration in Male Diabetic Rats. Medicina 2024, 60, 1224.
https://doi.org/10.3390/medicina60081224
AMA Style
Ongan B, Ekici Ö, Sadi G, Aslan E, Pektaş MB.
Mangiferin Induces Post-Implant Osteointegration in Male Diabetic Rats. Medicina. 2024; 60(8):1224.
https://doi.org/10.3390/medicina60081224
Chicago/Turabian Style
Ongan, Bünyamin, Ömer Ekici, Gökhan Sadi, Esra Aslan, and Mehmet Bilgehan Pektaş.
2024. "Mangiferin Induces Post-Implant Osteointegration in Male Diabetic Rats" Medicina 60, no. 8: 1224.
https://doi.org/10.3390/medicina60081224
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