Role of Systemic Immune Inflammation Index, Systemic Immune Response Index, Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Predicting Peritoneal Culture Positivity and Prognosis in Cases of Spontaneous Bacterial Peritonitis Admitted to the Emergency Department
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Study Population
2.3. Data Collection
2.4. Outcomes
2.5. Measurement Tools
- -
- SII: (N × P)/L
- -
- SIRI: (N × M)/L
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- NLR: N/L
- -
- PLR: P/L
- where N represents neutrophil, P represents platelet, L represents lymphocyte and M represents monocyte values.
2.6. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Statistics | |
---|---|
Age | 50.72 ± 29.28 |
Gender | |
Female | 122 (44.4%) |
Male | 153 (55.6%) |
Spontaneous or secondary peritonitis | |
Spontaneous | 156 (56.7%) |
Secondary | 119 (43.3%) |
Peritoneal culture result | |
Negative | 183 (66.5%) |
Positive | 92 (33.5%) |
Need for intensive care | |
No | 218 (79.3%) |
Yes | 57 (20.7%) |
Exitus | |
No | 156 (56.7%) |
Yes | 119 (43.3%) |
Number of days in hospital | 14.42 ± 11.29 |
CRP | 75.69 ± 84.88 |
Albumin | 27.30 ± 10.79 |
Leukocyte | 11.73 ± 7.45 |
Neutrophil | 9.05 ± 8.78 |
Lymphocyte | 2.16 ± 8.01 |
Platelet | 254.34 ± 142.76 |
Monocyte | 0.86 ± 0.57 |
RDW | 16.55 ± 3.30 |
INR | 1.42 ± 0.46 |
SII | 2392.70 ± 3210.46 |
SIRI | 7.66 ± 9.85 |
NLR | 9.57 ± 14.01 |
PLR | 308.72 ± 610.23 |
Test Result Variables | Cut-Off | AUC | Std. Error | p | Asymptotic 95% Confidence Interval | Sensitivity | Specificity | |
---|---|---|---|---|---|---|---|---|
Lower Bound | Upper Bound | |||||||
SII | >1228.45 | 0.633 | 0.034 | <0.001 | 0.565 | 0.700 | 65.20 | 53.00 |
SIRI | >4.29 | 0.546 | 0.037 | 0.209 | 0.475 | 0.618 | 53.30 | 53.00 |
NLR | >6.00 | 0.592 | 0.035 | 0.013 | 0.523 | 0.661 | 57.60 | 55.20 |
PLR | >176.17 | 0.614 | 0.035 | 0.002 | 0.545 | 0.684 | 64.10 | 55.20 |
Peritoneal Culture Results | Test Statistic | p | ||
---|---|---|---|---|
Positive | Negative | |||
Age | 56.28 ± 25.22 | 47.93 ± 30.80 | −1.690 | 0.091 |
SII | 2718.21 ± 2504.32 | 2229.05 ± 3507.26 | −3.598 | <0.001 |
SIRI | 8.80 ± 12.24 | 7.08 ± 8.38 | −1.256 | 0.209 |
NLR | 9.72 ± 7.61 | 9.49 ± 16.33 | −2.497 | 0.013 |
PLR | 422.91 ± 982.96 | 251.31 ± 260.03 | −3.096 | 0.002 |
WBC | 13.04 ± 8.86 | 11.07 ± 6.55 | −1.789 | 0.074 |
Neutrophil | 9.45 ± 6.63 | 8.84 ± 9.69 | −2.051 | 0.040 |
Lymphocyte | 2.12 ± 8.36 | 2.18 ± 7.85 | −1.144 | 0.253 |
Platelet | 285.11 ± 142.24 | 238.87 ± 140.87 | −3.106 | 0.002 |
Monocyte | 0.84 ± 0.57 | 0.86 ± 0.57 | −0.074 | 0.941 |
Test Result Variables | Cut-Off | AUC | Std. Error | p | Asymptotic 95% Confidence Interval | Sensitivity | Specificity | |
---|---|---|---|---|---|---|---|---|
Lower Bound | Upper Bound | |||||||
SII | >1236.70 | 0.605 | 0.043 | 0.014 | 0.521 | 0.690 | 64.90 | 51.40 |
SIRI | >4.17 | 0.577 | 0.042 | 0.074 | 0.495 | 0.659 | 56.10 | 51.40 |
NLR | >5.88 | 0.600 | 0.042 | 0.020 | 0.517 | 0.682 | 61.40 | 52.30 |
PLR | >193.84 | 0.599 | 0.041 | 0.021 | 0.519 | 0.680 | 63.20 | 58.30 |
Test Result Variables | Cut-Off | AUC | Std. Error | p | Asymptotic 95% Confidence Interval | Sensitivity | Specificity | |
---|---|---|---|---|---|---|---|---|
Lower Bound | Upper Bound | |||||||
SII | >1296.63 | 0.312 | 0.035 | 0.001 | 0.545 | 0.680 | 63.00 | 62.20 |
SIRI | >3.97 | 0.522 | 0.035 | 0.528 | 0.453 | 0.591 | 54.60 | 50.00 |
NLR | >5.92 | 0.584 | 0.035 | 0.017 | 0.516 | 0.651 | 58.80 | 55.80 |
PLR | >167.13 | 0.561 | 0.035 | 0.081 | 0.493 | 0.630 | 60.50 | 50.00 |
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Efgan, M.G.; Acar, H.; Kanter, E.; Kırık, S.; Duman Şahan, T. Role of Systemic Immune Inflammation Index, Systemic Immune Response Index, Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Predicting Peritoneal Culture Positivity and Prognosis in Cases of Spontaneous Bacterial Peritonitis Admitted to the Emergency Department. Medicina 2024, 60, 1335. https://doi.org/10.3390/medicina60081335
Efgan MG, Acar H, Kanter E, Kırık S, Duman Şahan T. Role of Systemic Immune Inflammation Index, Systemic Immune Response Index, Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Predicting Peritoneal Culture Positivity and Prognosis in Cases of Spontaneous Bacterial Peritonitis Admitted to the Emergency Department. Medicina. 2024; 60(8):1335. https://doi.org/10.3390/medicina60081335
Chicago/Turabian StyleEfgan, Mehmet Göktuğ, Hüseyin Acar, Efe Kanter, Süleyman Kırık, and Tutku Duman Şahan. 2024. "Role of Systemic Immune Inflammation Index, Systemic Immune Response Index, Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Predicting Peritoneal Culture Positivity and Prognosis in Cases of Spontaneous Bacterial Peritonitis Admitted to the Emergency Department" Medicina 60, no. 8: 1335. https://doi.org/10.3390/medicina60081335