Deceased Donor Uterus Transplantation: A Narrative Review of the First 24 Published Cases
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Worldwide Deceased Donor UTx Activity
3.2. Differences between Living (LD) and Deceased Donation (DD)
3.3. Surgical Technique of Uterus Retrieval from Deceased Donor
3.4. Vaginal Stenosis
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Country | N. of DD UTxs | N. of Live Births | Graft Failures |
---|---|---|---|
Turkey | 2 | 2 | 0 |
USA | 12 | 7 | 3 |
Brazil | 2 | 1 | 0 |
Czech Republic | 5 | 1 | 2 |
Italy | 3 | 1 | 1 |
Total | 24 | 12 | 25% |
N. | Year | Country | Recipient Age | Donor Age | Cause of AUFI | Parity of Donor | Outcome | Live Birth (n.), Gestational Age (w + d), Obstetrics Complications |
---|---|---|---|---|---|---|---|---|
1 | 2011 | Turkey [9,11] | 21 | 22 | MRKH syndrome | 0 | Cesarean hysterectomy | 1, 28 + 0, IUGR, pre-eclampsia |
2 | 2016 | USA (Cleveland) [13] | 29 | 30 | MRKH syndrome | NR | Hysterectomy day 12 | NA |
3 | 2016 | USA (Baylor) [15] | 36 | 33 | MRKH syndrome | 3 | Cesarean hysterectomy | 1, 37 + 6 |
4 | 2016 | Czech Republic [21] | 30 | 57 | MRKH syndrome | 1 | Hysterectomy day 7 | 0 |
5 | 2016 | Czech Republic [22] | 26 | 24 | MRKH syndrome | 0 | In situ | 0 |
6 | 2016 | Brazil [6] | 32 | 45 | MRKH syndrome | 3 | Cesarean hysterectomy | 1, 35 + 3, pyelonephritis |
7 | 2017 | Czech Republic [17] | 25 | 20 | MRKH syndrome | 0 | Cesarean hysterectomy, vaginal stenosis | 1, 34 + 6, diabetes mellitus |
8 | 2017 | Czech Republic [23] | 33 | 56 | MRKH syndrome | 1 | Hysterectomy month 7, vaginal stenosis | 0 |
9 | 2017 | USA (Baylor) [24] | 29 | 44 | MRKH syndrome | NR | Graft loss | 0 |
10 | 2017 | USA (Cleveland) [14] | 35 | 24 | MRKH syndrome | NR | Cesarean hysterectomy | 1, 34 + 1, placenta accreta, impaired renal function |
11 | 2018 | Czech Republic [16] | 29 | 45 | MRKH syndrome | NR | In situ, vaginal stenosis | 0 |
12 | 2018 | USA (Penn) [15] | 33 | NR | MRKH syndrome | NR | NR | 1 |
13–17 | 2019 | USA [15] | NR | NR | NR | NR | NR | 3 |
18 | 2019 | USA (Cleveland) | 31 | NR | NR | NR | NR | 1 |
19 | 2020 | Italy [20] | 27 | 37 | MRKH syndrome | 2 | In situ, vaginal stenosis | 1 |
20 | 2020 | USA [15] | NR | NR | NR | NR | NR | NR |
21 | 2021 | Turkey [12] | 32 | 37 | MRKH syndrome | 3 | In situ | 1, 29 + 0, PPROM |
22 | 2022 | Italy (in press) | 33 | 43 | MRKH syndrome | 0 | In situ, vaginal stenosis | 0 |
23 | 2023 | Italy (in press) | 27 | 25 | MRKH syndrome | 0 | Graft rejection | 0 |
24 | NR | Brazil [12] | NR | NR | NR | NR | NR | 0 |
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Pecorino, B.; Scibilia, G.; Ferrara, M.; Veroux, P.; Chiofalo, B.; Scollo, P. Deceased Donor Uterus Transplantation: A Narrative Review of the First 24 Published Cases. Medicina 2024, 60, 1348. https://doi.org/10.3390/medicina60081348
Pecorino B, Scibilia G, Ferrara M, Veroux P, Chiofalo B, Scollo P. Deceased Donor Uterus Transplantation: A Narrative Review of the First 24 Published Cases. Medicina. 2024; 60(8):1348. https://doi.org/10.3390/medicina60081348
Chicago/Turabian StylePecorino, Basilio, Giuseppe Scibilia, Martina Ferrara, Pierfrancesco Veroux, Benito Chiofalo, and Paolo Scollo. 2024. "Deceased Donor Uterus Transplantation: A Narrative Review of the First 24 Published Cases" Medicina 60, no. 8: 1348. https://doi.org/10.3390/medicina60081348