Investigating the Overlap of Hikikomori and Autism Spectrum Disorder: A Case Report
Abstract
:1. Introduction
2. Case Report
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Authors and Years | Type of Manuscript | Demographics (Sex and Age) | Findings |
---|---|---|---|
Maglia et al., 2020 [14] | Case report | n = 1 (male) 18 years old | Systemic relational therapy as rehabilitation. |
Koyama et al., 2010 [15] | Case (epidemiological) study | n = 1660 (male/female) 20–49 years old | There were 1.2% affected (1.8 male/0.4 female), while 45.5% did not have a lifetime prevalence of another psychiatric disorder. |
Hayakawa et al., 2018 [16] | Case control study | n = 101 (male 46/female 55) 21 years old | Lower serum uric acid levels in men and lower high-density lipoprotein cholesterol levels in women with hikikomori compared with healthy controls. |
Bellini B et al., 2024 [18] | Case control study | Hikikomori group n = 22 (11 males and 11 females) 12–17 years Control group n = 22 (8 males and 14 females) 11–17 years | Hikikomori syndrome is not secondary to a mood disorder, but prolonged social withdrawal can be a risk factor for depressive episodes. The hikikomori patients appeared less depressed, with a shorter duration of withdrawal, while their depressive symptoms may be intensified by longer social isolation. |
Hamasaki et al., 2021 [19] | Case control study | Study group n = 20 (10 males/10 females); control group n = 88 (56 males/32 females) aged 12–15 years | The CBCL subscale “withdrawn” was found to be correlated to hikikomori. The independent variables correlated with hikikomori severity were “somatic complaints”, “anxious/depressed”, “overuse of the Internet”, and “lack of communication between parents”. |
Hamasaki et al., 2022 [20] | Case control study | Study group n = 10 (7 males/3 females); control group n = 115 (58 males/57 females) aged 12–15 years | Hikikomori in Japan and France could be considered essentially the same phenomenon. |
Silic, 2019 [21] | Case report | n = 1 male, 24 years old | The differential diagnosis of hikikomori with other conditions can be challenging. For the authors, hikikomori is a stand-alone clinical condition. |
Benarous, 2022 [22] | Retrospective study | n = 191 adolescents (84 males/107 females) aged 12–18 | Patients with hikikomori present distinct clinical features compared to those with other kinds of school refusal or social withdrawal. |
Santona et al., 2023 [23] | Case study | n = 72 young adults (49 males/23 females) 12–33 years Mean age 22.5 years | An anxious attachment increased the odds of experiencing extremely high levels of interpersonal sensitivity and depression. |
Authors and Years | Type of Manuscript | Demographics (Sex and Age) | Findings |
---|---|---|---|
Carpita B et al., 2024 [11] | Case report | n = 2 (male) 40 and one 20-year-old | The study explores the correlation between autistic traits, mood symptoms, and traits of Internet gaming disorder. |
Brosnan et al., 2023 [13] | Case (epidemiological) study | n = 646 (male 283/363 female) 16–24 years old | Psychological wellbeing and COVID-19 restrictions are associated with increased hikikomori risk in young adults, and both associations are mediated by higher levels of autistic traits. |
Katsuki et al., 2020 [17] | Case control study | n = 324 (male 174/female 150) ≥15 years old (mean 31–35) | The study explores the association between autistic tendencies, difficulty in social communication, and social interaction. |
Carpita et al., 2024 [12] | Population study | n = 1192 (577 male/615 female) university students | Autistic features can trigger the development of hikikomori in both sexes, which is in line with the rising hypothesis of a possible neurodevelopmental basis for different psychiatric disorders. |
Yamada et al., 2023 [24] | Case control study | Control group n = 23 males with ASD; case group n = 16 males with ASD and hikikomori | ASD patients with hikikomori are more likely to have greater sensory abnormalities, comorbid atopic dermatitis, lower uric acid levels, and stronger depressive and anxiety tendencies. |
Neuropsychological Assessments | Scores | |
---|---|---|
Autism symptomatology | Ados II Module 3 | Social affection score: 9 Restricted and repetitive behaviors: 1 Total score: 10 Comparison score: 6 |
ADI-R | Qualitative anomalies in the following: Area of mutual social interaction: 15 Area of communication: 10 Area of restricted, repetitive, and stereotyped patterns of behavior: 9 | |
Neuropsychological profile | K-SADS | Depressive disorder area: depressed mood (irritability, anger, anhedonia, non-suicidal self-injury behavior) Anxiety area: social anxiety |
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© 2025 by the authors. Published by MDPI on behalf of the Lithuanian University of Health Sciences. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Moro, M.; de Gioia, A.; D’Amario, G.; Napoli, V.; Venezia, I.; Mirra, F.; D’Ambrosio, M.; Venditti, R.; Sestito, S.; De Stefano, A.; et al. Investigating the Overlap of Hikikomori and Autism Spectrum Disorder: A Case Report. Medicina 2025, 61, 637. https://doi.org/10.3390/medicina61040637
Moro M, de Gioia A, D’Amario G, Napoli V, Venezia I, Mirra F, D’Ambrosio M, Venditti R, Sestito S, De Stefano A, et al. Investigating the Overlap of Hikikomori and Autism Spectrum Disorder: A Case Report. Medicina. 2025; 61(4):637. https://doi.org/10.3390/medicina61040637
Chicago/Turabian StyleMoro, Marianna, Alessia de Gioia, Giulia D’Amario, Valentina Napoli, Ilaria Venezia, Federica Mirra, Martina D’Ambrosio, Romina Venditti, Simona Sestito, Andrea De Stefano, and et al. 2025. "Investigating the Overlap of Hikikomori and Autism Spectrum Disorder: A Case Report" Medicina 61, no. 4: 637. https://doi.org/10.3390/medicina61040637
APA StyleMoro, M., de Gioia, A., D’Amario, G., Napoli, V., Venezia, I., Mirra, F., D’Ambrosio, M., Venditti, R., Sestito, S., De Stefano, A., Di Domenico, S., Romeo, D., Mercuri, E., & Brogna, C. (2025). Investigating the Overlap of Hikikomori and Autism Spectrum Disorder: A Case Report. Medicina, 61(4), 637. https://doi.org/10.3390/medicina61040637