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Marine Drugs
Volume 21
Issue 12
10.3390/md21120640
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Article

Streptinone, a New Indanone Derivative from a Marine-Derived Streptomyces massiliensis, Inhibits Particulate Matter-Induced Inflammation

by
Hwa-Sun Lee
1,2,
Dineth Pramuditha Nagahawatta
3,
You-Jin Jeon
3,
Min Ah Lee
1,2,
Chang-Su Heo
1,4,
Sun Joo Park
2 and
Hee Jae Shin
1,4,*
1
Marine Natural Products Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Republic of Korea
2
Department of Chemistry, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 48513, Republic of Korea
3
Department of Marine Life Sciences, Jeju National University, 102 Jeju Daehak-ro, Jeju 63243, Republic of Korea
4
Department of Marine Biotechnology, University of Science and Technology (UST), 217 Gajung-ro, Yuseong-gu, Daejeon 34113, Republic of Korea
*
Author to whom correspondence should be addressed.
Mar. Drugs 2023, 21(12), 640; https://doi.org/10.3390/md21120640
Submission received: 30 November 2023 / Revised: 11 December 2023 / Accepted: 13 December 2023 / Published: 14 December 2023
(This article belongs to the Special Issue Marine Natural Products with Anti-Inflammatory Effects)
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Abstract

Inflammatory diseases caused by air pollution, especially from particulate matter (PM) exposure, have increased daily. Accordingly, attention to treatment or prevention for these inflammatory diseases has grown. Natural products have been recognized as promising sources of cures and prevention for not only inflammatory but also diverse illnesses. As part of our ongoing study to discover bioactive compounds from marine microorganisms, we isolated streptinone, a new indanone derivative (1), along with three known diketopiperazines (2–4) and piericidin A (5), from a marine sediment-derived Streptomyces massiliensis by chromatographic methods. The structure of 1 was elucidated based on the spectroscopic data analysis. The relative and absolute configurations of 1 were determined by 1H-1H coupling constants, 1D NOESY, and ECD calculation. The anti-inflammatory activities of 1 were evaluated through enzyme-linked immunosorbent assay (ELISA), Western blot, and qPCR. Compound 1 suppressed the production of nitric oxide (NO), prostaglandin E2 (PGE2), and pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β, by inhibiting the Toll-like receptor (TLR)-mediated nuclear factor kappa B (NF-κB) signaling pathway. Therefore, compound 1 could potentially be used as an agent in the prevention and treatment of diverse inflammatory disorders caused by particulate matter.
Keywords: Streptomyces massilinesis; indanone; particulate matter; anti-inflammation Streptomyces massilinesis; indanone; particulate matter; anti-inflammation
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MDPI and ACS Style

Lee, H.-S.; Nagahawatta, D.P.; Jeon, Y.-J.; Lee, M.A.; Heo, C.-S.; Park, S.J.; Shin, H.J. Streptinone, a New Indanone Derivative from a Marine-Derived Streptomyces massiliensis, Inhibits Particulate Matter-Induced Inflammation. Mar. Drugs 2023, 21, 640. https://doi.org/10.3390/md21120640

AMA Style

Lee H-S, Nagahawatta DP, Jeon Y-J, Lee MA, Heo C-S, Park SJ, Shin HJ. Streptinone, a New Indanone Derivative from a Marine-Derived Streptomyces massiliensis, Inhibits Particulate Matter-Induced Inflammation. Marine Drugs. 2023; 21(12):640. https://doi.org/10.3390/md21120640

Chicago/Turabian Style

Lee, Hwa-Sun, Dineth Pramuditha Nagahawatta, You-Jin Jeon, Min Ah Lee, Chang-Su Heo, Sun Joo Park, and Hee Jae Shin. 2023. "Streptinone, a New Indanone Derivative from a Marine-Derived Streptomyces massiliensis, Inhibits Particulate Matter-Induced Inflammation" Marine Drugs 21, no. 12: 640. https://doi.org/10.3390/md21120640

APA Style

Lee, H.-S., Nagahawatta, D. P., Jeon, Y.-J., Lee, M. A., Heo, C.-S., Park, S. J., & Shin, H. J. (2023). Streptinone, a New Indanone Derivative from a Marine-Derived Streptomyces massiliensis, Inhibits Particulate Matter-Induced Inflammation. Marine Drugs, 21(12), 640. https://doi.org/10.3390/md21120640

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