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Marine Drugs
Volume 22
Issue 1
10.3390/md22010012
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Article

Marine Bioprospecting: Enzymes and Stress Proteins from the Sea Anemones Anthopleura dowii and Lebrunia neglecta

by
Santos Ramírez-Carreto
1,
Beatriz Miranda-Zaragoza
2,
Nuno Simões
3,4,5,
Ricardo González-Muñoz
6 and
Claudia Rodríguez-Almazán
2,*
1
Instituto Nacional de Salud Pública, Centro de Investigación Sobre Enfermedades Infecciosas, Av. Universidad #655, Santa María Ahuacatitlan, Cuernavaca C.P. 62100, Mexico
2
Departamento de Micro y Nanotecnologías, Instituto de Ciencias Aplicadas y Tecnología, Universidad Nacional Autónoma de México, Cto. Exterior S/N, C.U., Coyoacán, Ciudad de México C.P. 04510, Mexico
3
Unidad Multidisciplinaria de Docencia e Investigación en Sisal, Facultad de Ciencias, Universidad Nacional Autónoma de México, Puerto Abrigo s/n, Sisal C.P. 97356, Mexico
4
International Chair for Coastal and Marine Studies, Harte Research Institute for Gulf of Mexico Studies, Texas A and M University-Corpus Christi, Corpus Christi, TX 78412, USA
5
Laboratorio Nacional de Resiliencia Costera (LANRESC), Laboratorios Nacionales, CONACYT, Sisal C.P. 97356, Mexico
6
Instituto de Investigaciones Marinas y Costeras, CONICET, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Dean Funes 3350, Mar del Plata C.P. 7600, Argentina
*
Author to whom correspondence should be addressed.
Mar. Drugs 2024, 22(1), 12; https://doi.org/10.3390/md22010012
Submission received: 18 October 2023 / Revised: 13 December 2023 / Accepted: 20 December 2023 / Published: 23 December 2023
(This article belongs to the Special Issue Proteomic Studies for the Identification and Characterization of Marine Bioactive Molecules)
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Abstract

The bioprospecting of sea anemone tissues and secretions has revealed that they are natural libraries of polypeptides with diverse biological activities that can be utilized to develop of biotechnological tools with potential medical and industrial applications. This study conducted a proteomic analysis of crude venom extracts from Anthopleura dowii Verrill, 1869, and Lebrunia neglecta Duchassaing & Michelotti, 1860. The obtained data allowed us to identify 201 polypeptides, of which 39% were present in both extracts. Among the obtained sequences, hydrolase-type enzymes, oxidoreductases, transferases, heat shock proteins, adhesion proteins, and protease inhibitors, among others, were identified. Interaction analysis and functional annotation indicated that these proteins are primarily involved in endoplasmic reticulum metabolic processes such as carbon metabolism and protein processing. In addition, several proteins related to oxidative stress were identified, including superoxide dismutase, peroxiredoxins, thioredoxin, and glutathione oxidase. Our results provide novel information on the polypeptide composition of the crude venom extract from sea anemones, which can be utilized to develop molecules for therapeutic tools and industrial applications.
Keywords: Lebrunia neglecta; Anthopleura dowii; proteome; crude venom extract; enzymes; sea anemone Lebrunia neglecta; Anthopleura dowii; proteome; crude venom extract; enzymes; sea anemone

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MDPI and ACS Style

Ramírez-Carreto, S.; Miranda-Zaragoza, B.; Simões, N.; González-Muñoz, R.; Rodríguez-Almazán, C. Marine Bioprospecting: Enzymes and Stress Proteins from the Sea Anemones Anthopleura dowii and Lebrunia neglecta. Mar. Drugs 2024, 22, 12. https://doi.org/10.3390/md22010012

AMA Style

Ramírez-Carreto S, Miranda-Zaragoza B, Simões N, González-Muñoz R, Rodríguez-Almazán C. Marine Bioprospecting: Enzymes and Stress Proteins from the Sea Anemones Anthopleura dowii and Lebrunia neglecta. Marine Drugs. 2024; 22(1):12. https://doi.org/10.3390/md22010012

Chicago/Turabian Style

Ramírez-Carreto, Santos, Beatriz Miranda-Zaragoza, Nuno Simões, Ricardo González-Muñoz, and Claudia Rodríguez-Almazán. 2024. "Marine Bioprospecting: Enzymes and Stress Proteins from the Sea Anemones Anthopleura dowii and Lebrunia neglecta" Marine Drugs 22, no. 1: 12. https://doi.org/10.3390/md22010012

APA Style

Ramírez-Carreto, S., Miranda-Zaragoza, B., Simões, N., González-Muñoz, R., & Rodríguez-Almazán, C. (2024). Marine Bioprospecting: Enzymes and Stress Proteins from the Sea Anemones Anthopleura dowii and Lebrunia neglecta. Marine Drugs, 22(1), 12. https://doi.org/10.3390/md22010012

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