New Bioactive Polyketides from the Mangrove-Derived Fungus Penicillium sp. SCSIO 41411
Abstract
:1. Introduction
2. Results and Discussion
2.1. Structural Determination
2.2. Bioactivity Assay
3. Materials and Methods
3.1. General Experimental Procedures
3.2. Fungal Material
3.3. Fermentation and Extraction
3.4. Isolation and Purification
3.5. Spectroscopic Data of Compounds
3.6. X-ray Crystallographic Analysis
3.7. ECD Computation Section
3.8. Mosher’s Method
3.9. Antibacterial Activity Assay
3.10. Antioxidant Activity Assay
3.11. PDE4 Inhibitory Screening Assays
3.12. Cytotoxicity Bioassay
3.13. Molecular Docking
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Pos. | 1 a | 5 b | ||
---|---|---|---|---|
δC Type | δH (J in Hz) | δC Type | δH (J in Hz) | |
1 | 168.3, C | 173.3, C | ||
2 | 67.0, CH | 5.27, s | ||
3 | 81.5, CH | 5.26, br s | 126.6, C | |
4 | 134.3, C | 146.9, C | ||
5 | 157.3, C | 115.8, CH | 6.60, d (8.5) | |
6 | 104.2, CH | 6.41, s | 115.2, CH | 6.50, dd (8.5, 3.0) |
7 | 153.7, C | 149.7, C | ||
8 | 103.4, C | 114.2, CH | 6.67, d (3.0) | |
9 | 141.5, C | 51.5, CH3 | 3.57, s | |
10 | 59.7, CH3 | 3.69, s | ||
1′ | 65.1, CH | 4.18, q (5.9) | ||
2′ | 20.6, CH3 | 1.28, d (6.5) |
Pos. | 3 a | 4 b | ||
---|---|---|---|---|
δC Type | δH (J in Hz) | δC Type | δH (J in Hz) | |
1 | 172.7, C | 183.6, C | ||
2 | 144.2, C | 161.9, C | ||
3 | 115.6, CH | 6.96, s | 104.0, CH | 5.88, s |
4 | 160.0, C | 184.5, C | ||
5 | 150.2, C | 156.1, C | ||
6 | 120.1, C | |||
7 | 153.0, C | 23.3, CH2 | 2.40, t (7.7) | |
8 | 27.5, CH2 | 2.68, t (7.5) | 29.2, CH2 | 1.43, m |
9 | 26.1, CH2 | 1.61, m | 30.2, CH2 | 1.32, m |
10 | 28.3, CH2 | 1.30, m | 30.6, CH2 | 1.29, m |
11 | 28.4, CH2 | 1.30, m | 33.0, CH2 | 1.29, m |
12 | 31.1, CH2 | 1.24, m | 23.7, CH2 | 1.32, m |
13 | 22.0, CH2 | 1.24, m | 14.4, CH3 | 0.90, t (7.1) |
14 | 13.9, CH3 | 0.85, t (6.8) | 57.2, CH3 | 3.83, s |
15 | 53.3, CH3 | 3.87, s |
Compounds | Antibacterial (MIC, µg/mL) | Cytotoxicity (IC50, µM) | |||
---|---|---|---|---|---|
S. aureus | S. suis | PC-3 | LNCaP | DU145 | |
1 | - a | - | - | - | - |
3 | - | 100 | - | - | - |
4 | - | - | 18.69 | 31.62 | >100 |
7 | 100 | 100 | - | - | - |
8 | - | 100 | - | - | - |
9 | 100 | 100 | - | - | - |
12 | - | - | - | - | - |
Positive | 25 b | 50 c | 0.12 d | 0.0018 d | 0.0033 d |
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Chen, Y.; Cai, J.; Xia, Z.; Chen, C.; Liu, Y.; Jayasinghe, L.; Wang, X.; Zhou, X. New Bioactive Polyketides from the Mangrove-Derived Fungus Penicillium sp. SCSIO 41411. Mar. Drugs 2024, 22, 384. https://doi.org/10.3390/md22090384
Chen Y, Cai J, Xia Z, Chen C, Liu Y, Jayasinghe L, Wang X, Zhou X. New Bioactive Polyketides from the Mangrove-Derived Fungus Penicillium sp. SCSIO 41411. Marine Drugs. 2024; 22(9):384. https://doi.org/10.3390/md22090384
Chicago/Turabian StyleChen, Yi, Jian Cai, Ziwei Xia, Chunmei Chen, Yonghong Liu, Lalith Jayasinghe, Xueni Wang, and Xuefeng Zhou. 2024. "New Bioactive Polyketides from the Mangrove-Derived Fungus Penicillium sp. SCSIO 41411" Marine Drugs 22, no. 9: 384. https://doi.org/10.3390/md22090384