Bio-Active Products from Mangrove Ecosystems 2.0

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 3035

Special Issue Editor


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Guest Editor
One Health Institute, School of Chemical Engineering and Technology, Hainan University, Haikou 570228, China
Interests: secondary metabolites of medicinal plants and mangrove microorganisms; development of drug lead compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Mangrove communities represent a coastal habitat located in the intertidal zone or brackish water of tropical and subtropical coastal areas between 5°N and 5°S latitudes spanning over 118 countries. Special ecological conditions of mangroves include high salinity, nutrient limitation, tidal gradients, high temperatures, excessively high light, and muddy anaerobic or sandy soil, which lead to various morphological and physiological adaptations of inhabiting species and act as an effective selector for metabolic pathways via the generation of unique functional metabolites with highly unique chemical scaffolds and pharmaceutical application potential. In recent decades, numerous metabolites with uncommon structures and efficacious bioactivities have been discovered in mangrove-derived microorganisms, along with mangrove plants. For this reason, mangrove ecosystems have earned the most attention from organic chemists and pharmacologists as an attractive biodiversity hotspot. Additionally, many unique and novel chemical structures with a wide range of structural classes have various biosynthetic origins containing novel functional genes and corresponding enzymes with unique catalytic functions. In this Special Issue, we welcome articles on recent studies and pertinent reviews that focus on the latest and most important developments in bioactive product discovery from mangrove ecosystems and correlating structures with chemical synthesis, biosynthesis, genomic and metabolomics approaches, biological activities, and pharmaceutical mechanisms. We are now in the process of assembling a group of top researchers whose work we would like to feature in this collection, and we would like you to participate.

Prof. Dr. Jing Xu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mangrove ecosystems
  • bio-active products
  • signaling pathway
  • chemical synthesis and biosynthesis
  • genomic and metabolomics approaches

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Published Papers (1 paper)

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Review

54 pages, 3387 KiB  
Review
Chemical Constituents and Biological Activities of Bruguiera Genus and Its Endophytes: A Review
by Xiongming Luo, Xiaohong Chen, Lingli Zhang, Bin Liu, Lian Xie, Yan Ma, Min Zhang and Xiaobao Jin
Mar. Drugs 2024, 22(4), 158; https://doi.org/10.3390/md22040158 - 29 Mar 2024
Viewed by 2797
Abstract
The genus Bruguiera, a member of the Rhizophoraceae family, is predominantly found in coastal areas as a mangrove plant, boasting a rich and diverse community of endophytes. This review systematically compiled approximately 496 compounds derived from both the Bruguiera genus and its [...] Read more.
The genus Bruguiera, a member of the Rhizophoraceae family, is predominantly found in coastal areas as a mangrove plant, boasting a rich and diverse community of endophytes. This review systematically compiled approximately 496 compounds derived from both the Bruguiera genus and its associated endophytes, including 152 terpenoids, 17 steroids, 16 sulfides, 44 alkaloids and peptides, 66 quinones, 68 polyketides, 19 flavonoids, 38 phenylpropanoids, 54 aromatic compounds, and 22 other compounds. Among these, 201 compounds exhibited a spectrum of activities, including cytotoxicity, antimicrobial, antioxidant, anti-inflammatory, antiviral, antidiabetic, insecticidal and mosquito repellent, and enzyme inhibitory properties, etc. These findings provided promising lead compounds for drug discovery. Certain similar or identical compounds were found to be simultaneously present in both Bruguiera plants and their endophytes, and the phenomenon of their interaction relationship was discussed. Full article
(This article belongs to the Special Issue Bio-Active Products from Mangrove Ecosystems 2.0)
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