An Inventory of European Birth Cohorts
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Identification of the Cohorts
3.2. The European Panorama
3.3. The 45 Cohorts Starting Recruitment at Birth
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Nation | Acronym | N. Children | Enrolment Start | Follow-Up Status | Data Collected (Q: Questionnaire, PV: Patient Visit) | Data Origin 1 | Genetic Analysis | Biological Samples (If Taken) |
---|---|---|---|---|---|---|---|---|
Belgium | ENVIRONAGE | 1080 | 2010 | Ongoing | Q, PV | SR | Yes | Cord blood |
Belgium | FLEHS-I | 1196 | 2002 | Closed | Q, PV | SR | Yes | Blood, Cord blood, Exhaled breath condensate, Meconium, Saliva |
Czech Republic | CzECH | 7577 | 1994 | Closed | Q, PV | SR/PED | Yes | Cord blood, Urine |
Denmark | CCC2000 | 6090 | 2000 | Closed | PV | PED | No | |
Denmark | DARC | 562 | 1998 | Closed | Q, PV | SR/GYN-HCP/PED | No | Blood |
Finland | NFB C8586 | 9479 | 1985 | Closed | Q | SR | No | Info missing |
Finland | TURKU | 5356 | 1981 | Closed | PV | GYN-HCP/PED | No | |
France | AuBE | 302 | 2009 | Closed | Q | SR | No | Colostrum |
France | ELFE | 18,326 | 2011 | Ongoing | Q | SR | No | Cord blood, Hair, Urine |
France | Epifane | 3368 | 2012 | Closed | Q | SR | No | |
France | EPIPAGE 2 | 5567 | 2011 | Ongoing | Q, PV | SR/GYN-HCP | No | |
France | PARIS | 3840 | 2003 | Ongoing | Q, PV | SR/PED | No | Serum |
Germany | DONALD | 1300 | 1985 | Ongoing | Q, PV | PED | No | Urine |
Germany | GINIplus | 5991 | 1995 | Ongoing | Q, PV | PED | Yes | Cord blood, Serum |
Germany | KUNO | 2515 | 2015 | Ongoing | Q, PV | SR/PED | Yes | Buccal swab, Cord blood, Gingival smears, Hair, Skin swab, Stool, Urine |
Germany | LISA PLUS | 3097 | 1997 | Closed | Q | - | Yes | Serum |
Germany | MAS-90 | 1314 | 1990 | Closed | Q, PV | GYN-HCP/PED | Yes | Blood, Cord blood, Urine |
Germany | SPATZ | 1006 | 2012 | Ongoing | Q | SR | No | Blood, Breast milk, Hair, Urine |
Germany | UBCS | 1022 | 2000 | Closed | Q | SR | Yes | Breath test, Serum |
Italy | ITAL NEONAT | 697 | 2009 | Closed | Q, PV | PED | No | Info missing |
Italy | GASPII | 708 | 2003 | Ongoing | Q, PV | PED | Yes | Blood, Cord blood, Serum |
Italy | MUBICOS | 800 | 2009 | Ongoing | Q | SR | No | Saliva |
Italy | Piccolipiù | 3328 | 2011 | Ongoing | Q, PV | SR/PED | Yes | Blood, Cord blood, Urine |
Multinational | Europrevall | 12.049 | 2005 | Ongoing | Q | SR | Yes | Blood, Cord blood, |
Norway | ECA | 3754 | 1992 | Closed | Q, PV | SR/PED | Yes | Cord blood |
Norway | HUMIS | 2000 | 2003 | Ongoing | Q | SR | No | Breast milk, Cord blood |
Portugal | G21 | 8647 | 2005 | Ongoing | Q | - | No | Cord blood, Serum |
Slovakia | PCB | 1134 | 2002 | Closed | Q, PV | SR/GYN-HCP/PED | No | Cord blood |
Slovakia | PRENATAL | 1990 | 1997 | Closed | Q, PV | GYN-HCP | Yes | |
Sweden | ABIS | 16,058 | 1997 | Closed | Q, PV | PED | Yes | Blood, Breast milk, Serum |
Sweden | BAMSE | 4089 | 1994 | Ongoing | Q | SR | Yes | Blood, Plasma, Urine |
Sweden | H2GS | 2026 | 2007 | Closed | Q, PV | SR/PED | No | |
The Netherlands | Dutch | 236 | 1990 | Closed | Q, PV | SR/GYN-HCP/PED | No | |
The Netherlands | LucKi | 5000 | 2006 | Ongoing | Q, PV | SR/GYN-HCP | No | Meconium |
The Netherlands | TERNEUZEN | 2604 | 1977 | Closed | Q, PV | - | No | |
The Netherlands | WHISTLER | 2923 | 2003 | Ongoing | Q | - | No | |
Turkey | ADAPAR | 1377 | 2010 | Closed | Q, PV | SR/PED | No | Cord blood, Serum |
UK | ABERDEEN | 668 | 1921 | Closed | Q, PV | GYN-HCP | No | |
UK | EPICure | 308 | 1995 | Ongoing | Q | - | No | |
UK | FAIR | 969 | 2001 | Closed | Q | SR | No | |
UK | GEMINI | 2402 | 2007 | Closed | Q | SR | No | |
UK | GMS | 1029 | 1999 | Ongoing | Q, PV | SR | Yes | Blood, Saliva |
UK | GUS | 5217 | 2004 | Ongoing | Q | SR | No | |
UK | LRC | 10.350 | 1985 | Ongoing | Q | SR | No | Saliva |
UK | TEDS | 21.000 | 1994 | Ongoing | Q | SR | Yes | Info missing |
Nation | Acronym | Follow-Up Status | Main Objective |
---|---|---|---|
United Kingdom | ABERDEEN | Closed | To examine the effects of childhood mental ability on survival up to 76 years. |
Sweden | ABIS | Closed | To study the influence of environmental and genetic factors on the development of Type 1 Diabetes and other immune-mediated diseases such as allergy, asthma, coeliac disease, rheumatoid arthritis, inflammatory bowel disease, and cancer. |
Turkey | ADAPAR | Closed | To establish the prevalence of atopic dermatitis and identify associated risk factors by following infants from birth until 1 year of age. |
France | AuBE | Closed | To define the autonomic nervous system maturity profile obtained during the first two years of life by repeated polysomnography and 24-h electrocardiogram recordings and to determine the potential influence of this autonomic profile on sleep disorders and on cognitive development at the age of 3, as well as their impact on psychometric development at three years of age among term and preterm newborns. |
Denmark | CCC2000 | Closed | To study child psychopathology in the preschool and school years. |
Czech Republic | CzECH | Closed | To examine rates of lower respiratory illnesses in preschool children in relation to ambient particles and hydrocarbons. |
Denmark | DARC | Closed | To describe the prevalences and risk factors of sensitization and allergic diseases in childhood. |
The Netherlands | Dutch | Closed | To assess the association between body mass index and cognitive ability of young children. |
Norway | ECA | Closed | To determine any (detectable) association between environmental factors and the development of early childhood asthma. |
France | Epifane | Closed | To describe the ages for introduction of complementary food (ICF) during the first year of life and to identify maternal and infant factors associated with practices according to their agreement with the recommendations. |
United Kingdom | FAIR | Closed | To determine the incidence of parentally reported food hypersensitivity and objectively diagnosed food hypersensitivity during the first year of life. |
Belgium | FLEHS-I | Closed | To study the impact of outliers, determine the optimal unit for fat-soluble biomarkers in serum and quantify the major determinants for biomarkers of exposure to polychlorinated aromatic hydrocarbons (PCAHs) in three age groups. |
United Kingdom | GEMINI | Closed | To assess genetic and environmental influences in twins on growth during the first 5 y of life. |
Sweden | H2GS | Closed | To increase our understanding of the concept of child health and growth from a parental perspective, focusing on parental needs, and a medical/social perspective, elucidating risk factors for growth disturbances. |
Italy | ITAL NEONAT | Closed | To evaluate the role of prenatal, perinatal and postnatal conditions in determining the risk of hospitalization for bronchiolitis in a large cohort of preterms with gestational age 33 weeks or more and full-term newborns. |
Germany | LISA PLUS | Closed | To examine the impact of lifestyle-related factors, air pollution and genetics on immune system and childhood allergy development. |
Germany | MAS-90 | Closed | To trace the development and risk factors of allergic diseases prospectively from birth, determining the influence of life-style factors, environmental exposures, and health-related behavior. |
Finland | NFB C8586 | Closed | To examine risk factors involved in pre-term birth and intrauterine growth retardation, and the consequences of these early adverse outcomes on subsequent morbidity. |
Slovakia | PCB | Closed | To better understand the role of PCBs on children’s neurobehavioral and immunologic development. |
Slovakia | PRENATAL | Closed | To assess the contribution of modifiable environmental and dietary exposures to the development of infantile atopic eczema. |
The Netherlands | TERNEUZEN | Closed | To assess the relative contribution of body mass index SDS (standard deviation) changes between 0–18 y of age to adult overweight, and to identify the earliest relevant, critical growth period for adult overweight. |
Finland | TURKU | Closed | To assess growth and development at two years following respiratory distress syndrome. |
Germany | UBCS | Closed | To evaluate the role of maternal and perinatal factors on growth, BMI, health status of children. |
Sweden | BAMSE | ongoing | To study risk factors for asthma, allergic diseases and lung function and to study factors of importance for prognosis at already established disease. |
Germany | DONALD | ongoing | To evaluate the complex interrelations between nutritional behavior, food consumption, growth, development, nutritional and endocrine status, individuality, metabolism and health in children from infancy to adolescence and early adulthood. |
France | ELFE | ongoing | To understand how children’s health, development and socialization are affected by their environment, family circle, schooling and living conditions. |
Belgium | ENVIRONAGE | ongoing | To study the association between environmental and lifestyle factors and molecular targets of ageing measured at birth and in childhood, including telomere length and mitochondrial function |
United Kingdom | EPICure | ongoing | To study the survival and complications of premature infants up until discharge from hospital. |
France | EPIPAGE 2 | ongoing | To examine short- and long-term outcomes of very preterm children and their determinants. |
Multicenter | Europrevall | ongoing | To examine the complex interactions between food intake and metabolism, immune system, genetic background and socioeconomic factors to identify key risk factors and develop common European databases. |
Portugal | G21 | ongoing | To study determinants of differences in fetal and early life growth and body composition. |
Italy | GASPII | ongoing | To study the risk factors for childhood diseases and deepen the insight into the interaction between the genetic and the biological/environmental component on a cohort of infants. |
Germany | GINIplus | ongoing | To investigate whether the development of allergic diseases can be influenced by early childhood nutrition and to observe the natural course of atopic diseases (asthma, hay fever, neurodermatitis). Additional topics such as mental health, lung function, and nutrition were subsequently added. |
United Kingdom | GMS | ongoing | To investigate the antecedents of weight faltering and to study how children grow and develop and what contributes to their health. |
United Kingdom | GUS | ongoing | To understand child development through a holistic approach (social, genetic and environmental). |
Norway | HUMIS | ongoing | To study microbial, persistent organic pollutants, and other environmental exposures and child health outcomes. |
Germany | KUNO | ongoing | To contribute to the understanding of current child health using novel omics technologies in a systems medicine approach, to identify novel modifiable factors of child health and opportunities for prevention, and to provide a platform for investigating the feasibility and effectiveness of targeted interventions. |
United Kingdom | LRC | ongoing | To study the childhood epidemiology and potential risk factors of wheezing disorders and other common respiratory problems and to determine how many disease phenotypes exist. |
The Netherlands | LucKi | ongoing | To examine etiology and prognosis of atopic disease and overweight/obesity. |
Italy | MUBICOS | ongoing | To study the heritability and gene-environment interaction for major neonatal and pediatric outcomes in twins. |
France | PARIS | ongoing | To determine the incidence of respiratory and allergic symptoms and investigate the associations between these disorders and behavioral/environmental factors, especially indoor and outdoor pollution. |
Italy | Piccolipiù | ongoing | To investigate the association between genetic, obstetric, socioeconomic, environmental and lifestyle characteristics and risk factors and infant and childhood morbidity and development, and to describe the complex interactions between genetic, epigenetic, lifestyle factors and the environment. |
Germany | SPATZ | ongoing | To identify factors in childhood that influence asthma, allergies and obesity or precursors of these diseases in later life. |
United Kingdom | TEDS | ongoing | To better understand how genes and the environment influence learning abilities, cognitive abilities, and behavior. |
The Netherlands | WHISTLER | ongoing | To investigate determinants for wheezing illnesses (including neonatal lung function, viral infections, asthma-susceptibility genes and endotoxin exposure). |
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Pansieri, C.; Pandolfini, C.; Clavenna, A.; Choonara, I.; Bonati, M. An Inventory of European Birth Cohorts. Int. J. Environ. Res. Public Health 2020, 17, 3071. https://doi.org/10.3390/ijerph17093071
Pansieri C, Pandolfini C, Clavenna A, Choonara I, Bonati M. An Inventory of European Birth Cohorts. International Journal of Environmental Research and Public Health. 2020; 17(9):3071. https://doi.org/10.3390/ijerph17093071
Chicago/Turabian StylePansieri, Claudia, Chiara Pandolfini, Antonio Clavenna, Imti Choonara, and Maurizio Bonati. 2020. "An Inventory of European Birth Cohorts" International Journal of Environmental Research and Public Health 17, no. 9: 3071. https://doi.org/10.3390/ijerph17093071