Spatial Patterns of Endometriosis Incidence. A Study in Friuli Venezia Giulia (Italy) in the Period 2004–2017
Abstract
:1. Introduction
2. Materials
2.1. Incidence of Endometriosis
- At least one hospitalization with a diagnosis of endometriosis associated with the identification of endometriosis from the anatomic pathology database. The association was via a unique anonymous identifier of women and temporal proximity.
- At least one hospitalization with a diagnosis of endometriosis confirmed by laparoscopy or a surgical procedure allowing direct visualization.
- Identification of endometriosis from anatomic pathology database, without hospitalization with a diagnosis of endometriosis.
2.2. Standardized Incidence Ratios
3. Methods
3.1. Models for Disease Mapping
3.2. Profiling Municipalities at High Risk
3.2.1. Simple Approaches Based on p-values
3.2.2. Hierarchical Bayesian Mixture Model
3.3. Sensitivity Analysis
4. Results
4.1. Disease Mapping
4.2. Profiling Municipalities at High Risk
4.3. Sensitivity Analysis
5. Discussion
6. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Age | Women Residing in the Region * | Endometriosis n (Rates × 105) |
---|---|---|
15–20 | 402,526 | 48 (12) |
21–25 | 365,815 | 228 (62) |
26–30 | 442,259 | 631 (143) |
31–35 | 541,962 | 869 (160) |
36–40 | 633,878 | 846 (133) |
41–45 | 681,123 | 833 (122) |
46–50 | 654,892 | 670 (102) |
total 15–50 | 3,722,455 | 4125 (111) |
Decrease in Probability of the Null Hypothesis | |||||||
---|---|---|---|---|---|---|---|
Municipality | Number of Cases | SIR a | p-Value | q-Value | From 75% to No Less than | From 50% to No Less than | From 25% to No Less than |
San Canzian d’Isonzo | 38 | 1.759 | 0.0005 | 0.0522 | 0.0127 | 0.0043 | 0.0014 |
Staranzano | 41 | 1.720 | 0.0005 | 0.0522 | 0.0128 | 0.0043 | 0.0014 |
Ronchi dei Legionari | 62 | 1.498 | 0.0011 | 0.0640 | 0.0260 | 0.0088 | 0.0030 |
Monfalcone | 114 | 1.339 | 0.0012 | 0.0640 | 0.0287 | 0.0098 | 0.0033 |
Grado | 41 | 1.595 | 0.0019 | 0.0836 | 0.0442 | 0.0152 | 0.0051 |
Lusevera | 6 | 2.986 | 0.0046 | 0.1672 | 0.0924 | 0.0328 | 0.0112 |
San Lorenzo Isontino | 11 | 2.073 | 0.0085 | 0.2619 | 0.1480 | 0.0547 | 0.0189 |
Fiumicello | 26 | 1.565 | 0.0117 | 0.2858 | 0.1864 | 0.0709 | 0.0248 |
Codroipo | 72 | 1.307 | 0.0119 | 0.2858 | 0.1892 | 0.0722 | 0.0253 |
Mariano del Friuli | 10 | 1.998 | 0.0138 | 0.2982 | 0.2096 | 0.0812 | 0.0286 |
Morsano al Tagliamento | 15 | 1.697 | 0.0190 | 0.3253 | 0.2587 | 0.1042 | 0.0373 |
Latisana | 64 | 1.295 | 0.0191 | 0.3253 | 0.2593 | 0.1045 | 0.0374 |
Gradisca d’Isonzo | 31 | 1.438 | 0.0209 | 0.3253 | 0.2743 | 0.1119 | 0.0403 |
Capriva del Friuli | 11 | 1.798 | 0.0229 | 0.3253 | 0.2900 | 0.1198 | 0.0434 |
Turriaco | 16 | 1.624 | 0.0239 | 0.3253 | 0.2977 | 0.1238 | 0.0450 |
Prata di Pordenone | 42 | 1.350 | 0.0249 | 0.3253 | 0.3047 | 0.1275 | 0.0464 |
Barcis | 2 | 3.203 | 0.0256 | 0.3253 | 0.3096 | 0.1300 | 0.0475 |
Polcenigo | 17 | 1.557 | 0.0303 | 0.3528 | 0.3401 | 0.1466 | 0.0542 |
Cordenons | 78 | 1.233 | 0.0310 | 0.3528 | 0.3448 | 0.1492 | 0.0552 |
Fiume Veneto | 53 | 1.276 | 0.0359 | 0.3865 | 0.3726 | 0.1652 | 0.0619 |
Arba | 8 | 1.801 | 0.0376 | 0.3865 | 0.3811 | 0.1703 | 0.0640 |
Dolegna del Collio | 3 | 2.378 | 0.0394 | 0.3865 | 0.3901 | 0.1758 | 0.0664 |
Mossa | 9 | 1.689 | 0.0454 | 0.4263 | 0.4179 | 0.1931 | 0.0739 |
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Catelan, D.; Giangreco, M.; Biggeri, A.; Barbone, F.; Monasta, L.; Ricci, G.; Romano, F.; Rosolen, V.; Zito, G.; Ronfani, L. Spatial Patterns of Endometriosis Incidence. A Study in Friuli Venezia Giulia (Italy) in the Period 2004–2017. Int. J. Environ. Res. Public Health 2021, 18, 7175. https://doi.org/10.3390/ijerph18137175
Catelan D, Giangreco M, Biggeri A, Barbone F, Monasta L, Ricci G, Romano F, Rosolen V, Zito G, Ronfani L. Spatial Patterns of Endometriosis Incidence. A Study in Friuli Venezia Giulia (Italy) in the Period 2004–2017. International Journal of Environmental Research and Public Health. 2021; 18(13):7175. https://doi.org/10.3390/ijerph18137175
Chicago/Turabian StyleCatelan, Dolores, Manuela Giangreco, Annibale Biggeri, Fabio Barbone, Lorenzo Monasta, Giuseppe Ricci, Federico Romano, Valentina Rosolen, Gabriella Zito, and Luca Ronfani. 2021. "Spatial Patterns of Endometriosis Incidence. A Study in Friuli Venezia Giulia (Italy) in the Period 2004–2017" International Journal of Environmental Research and Public Health 18, no. 13: 7175. https://doi.org/10.3390/ijerph18137175