Differentiating between Seronegative Elderly-Onset Rheumatoid Arthritis and Polymyalgia Rheumatica: A Qualitative Synthesis of Narrative Reviews
Abstract
:1. Introduction
2. Methods
2.1. Study Selection
2.2. Data Extraction
2.3. Statistical Analysis
3. Results
3.1. Meta-Ethnography Results
3.2. Difficulty in Differentiation
3.2.1. Symptom Similarity at Initial Presentation
3.2.2. Clinical Picture of EORA with PMR Phenotype
3.3. Mandatory Follow-Up
3.3.1. Duration of Months and Years
3.3.2. Peripheral Lesions Follow-Up Leading to EORA Diagnosis
3.4. Factors Favoring Rheumatoid Arthritis
3.4.1. Initial Radiographic Change
3.4.2. Peripheral Arthritis
3.5. Factors Favoring Polymyalgia Rheumatica
3.5.1. Hip Joint Pain
3.5.2. Extracapsular Inflammation of Peripheral Lesions
3.5.3. Asymmetrical Small Joint Involvement
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Inclusion Criteria | Exclusion Criteria | |
---|---|---|
Population | EORA | Other diseases |
Types of study | Reviews | Original articles, non-empirical studies (editorial, news, and conference papers) |
Included content | Differentiation between EORA and PMR | - |
Other | Abstract available Full text available in English | Abstract not available Full text not available in English |
Year | Title | Purpose | Included Codes |
---|---|---|---|
2009 [8] | Elderly Onset Rheumatoid Arthritis Differential Diagnosis and Choice of First Line and Subsequent Therapy | To review the EORA subset of patients with regard to demographic and clinical features, therapeutic options, outcomes, and differential diagnosis of EORA from other elderly rheumatological conditions | Duration (in months and years) Asymmetrical small joint involvement |
2014 [17] | Polymyalgia rheumatica—diagnosis and classification | To differentiate PMR from other diseases | Symptomatic similarity at initial presentation Duration (in months and years) |
2016 [18] | Targeting Low Disease Activity in Elderly-Onset Rheumatoid Arthritis: Current and Future Roles of Biological Disease-Modifying Antirheumatic Drugs | To review the clinical features of EORA and obstacles that prevent rheumatologists from providing standard treatment to patients with EORA | Symptom similarity at initial presentation Duration (in months and years) |
2018 [19] | An autumn tale: geriatric rheumatoid arthritis | To review the clinical characteristics, prognosis, and treatment principles of EORA | Clinical picture of EORA with PMR phenotype Follow-up for peripheral lesions leading to EORA diagnosis Initial radiographic change Peripheral arthritis |
2018 [20] | Morning Stiffness in Elderly Patients with Rheumatoid Arthritis: What is Known About the Effect of Biological and Targeted Agents? | To review the impact of morning stiffness in patients with rheumatoid arthritis and summarize the efficacy of the biologic and targeted synthetic disease-modifying anti-rheumatic drugs in the alleviation of morning stiffness | Clinical picture of EORA with PMR phenotype Duration (in months and years) |
2019 [21] | Polymyalgia Rheumatica and Seronegative Elderly-Onset Rheumatoid Arthritis: Two Different Diseases with Many Similarities | To highlight the main differences and similarities between seronegative EORA, PMR, and PMR-like EORA | Symptom similarity at initial presentation Duration (in months and years) Initial radiographic change Peripheral arthritis |
2022 [22] | Treatment strategies for elderly-onset rheumatoid arthritis in the new era | To review effective differential diagnosis and treatment for EORA | Peripheral pain occurring in EORA and PMR Hip joint pain favoring PMR Extracapsular inflammation of peripheral lesions suggesting PMR Follow-up of peripheral lesions leading to EORA diagnosis Initial radiographic change Peripheral arthritis |
Theme | Concept |
---|---|
Difficulty in differentiation | Symptom similarity at initial presentation |
Clinical picture of EORA with PMR phenotype | |
Mandatory follow-up | Duration (in months and years) |
Peripheral lesions follow-up leading to EORA diagnosis | |
Favoring rheumatoid arthritis | Initial radiographic change |
Peripheral arthritis | |
Favoring PMR | Hip joint pain |
Extracapsular inflammation of peripheral lesions | |
Asymmetrical small joint involvement |
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Ohta, R.; Sano, C. Differentiating between Seronegative Elderly-Onset Rheumatoid Arthritis and Polymyalgia Rheumatica: A Qualitative Synthesis of Narrative Reviews. Int. J. Environ. Res. Public Health 2023, 20, 1789. https://doi.org/10.3390/ijerph20031789
Ohta R, Sano C. Differentiating between Seronegative Elderly-Onset Rheumatoid Arthritis and Polymyalgia Rheumatica: A Qualitative Synthesis of Narrative Reviews. International Journal of Environmental Research and Public Health. 2023; 20(3):1789. https://doi.org/10.3390/ijerph20031789
Chicago/Turabian StyleOhta, Ryuichi, and Chiaki Sano. 2023. "Differentiating between Seronegative Elderly-Onset Rheumatoid Arthritis and Polymyalgia Rheumatica: A Qualitative Synthesis of Narrative Reviews" International Journal of Environmental Research and Public Health 20, no. 3: 1789. https://doi.org/10.3390/ijerph20031789