Next Article in Journal
Prevalence and Determinants of Excessive Screen Viewing Time in Children Aged 3–15 Years and Its Effects on Physical Activity, Sleep, Eye Symptoms and Headache
Next Article in Special Issue
Polypharmacy and the Change of Self-Rated Health in Community-Dwelling Older Adults
Previous Article in Journal
Towards Sustainable Food Security through Regional Grain Supply and Demand Analysis in China
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJERPH
Volume 20
Issue 4
10.3390/ijerph20043448
ijerph-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Association between Serum Uric Acid Levels and Bone Mineral Density in Taiwanese Elderly Population

by
Pei-Ting Chung
1,
Hsiao-Chi Ma
2,
Sin-Yi Huang
1,
Hsin-Ning Lien
1,
Kuan-Hsun Ho
1,
Hsin-Yin Hsu
1,3,4,
Lee-Ching Hwang
1,4,
Meng-Ting Tsou
1,5,
Hsin-Hui Lin
2,4,* and
Hsin-Lung Chan
1,2,4,*
1
Department of Family Medicine, Mackay Memorial Hospital, Taipei 104217, Taiwan
2
Department of Family Medicine, Mackay Memorial Hospital, Tamsui Branch, New Taipei City 251020, Taiwan
3
Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 100025, Taiwan
4
Department of Medicine, Mackay Medical College, New Taipei City 252005, Taiwan
5
Mackay Junior College of Medicine, Nursing and Management, New Taipei City 252005, Taiwan
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2023, 20(4), 3448; https://doi.org/10.3390/ijerph20043448
Submission received: 13 December 2022 / Revised: 7 February 2023 / Accepted: 9 February 2023 / Published: 16 February 2023
(This article belongs to the Special Issue Geriatric Medicine: Public Health and Interdisciplinary Perspectives)
Browse Figure
Versions Notes

Abstract

Osteoporosis is a progressive metabolic bone disorder characterised by a decline in bone mineral density (BMD). Some previous studies have reported a controversial relationship between uric acid and osteoporosis. This cross-sectional study aimed to assess the association between serum uric acid levels and BMD in older adults from Taiwan. Data from participants aged ≥ 60 years were collected from 2008 to 2018. Furthermore, the participants were classified based on uric acid level quartiles. Regression models were used to assess the association between uric acid levels and bone health, including BMD values and risk of at least osteopenia. Crude and adjusted models of potential confounders, including age, sex and body mass index (BMI), were used. Compared with the first quartile of uric acid levels, the odds ratios for osteoporosis decreased in the higher uric acid level groups after adjustment for age, sex and BMI. The boxplot analysis showed that BMD values were higher in the groups with higher uric acid levels; moreover, the results of the multivariable linear regression model showed a consistent pattern. Notably, uric acid levels were positively correlated with BMD values. Higher uric acid levels in the elderly population might decrease the risk of at least osteopenia. As opposed to the anti-hyperuricemic policy for younger adults with a relatively lower risk of osteoporosis, BMD evaluation and urate-lowering therapy, goal adjustments should be considered for older adults with lower uric acid levels.
Keywords: osteoporosis; osteopenia; bone mineral density; hyperuricemia osteoporosis; osteopenia; bone mineral density; hyperuricemia

Share and Cite

MDPI and ACS Style

Chung, P.-T.; Ma, H.-C.; Huang, S.-Y.; Lien, H.-N.; Ho, K.-H.; Hsu, H.-Y.; Hwang, L.-C.; Tsou, M.-T.; Lin, H.-H.; Chan, H.-L. Association between Serum Uric Acid Levels and Bone Mineral Density in Taiwanese Elderly Population. Int. J. Environ. Res. Public Health 2023, 20, 3448. https://doi.org/10.3390/ijerph20043448

AMA Style

Chung P-T, Ma H-C, Huang S-Y, Lien H-N, Ho K-H, Hsu H-Y, Hwang L-C, Tsou M-T, Lin H-H, Chan H-L. Association between Serum Uric Acid Levels and Bone Mineral Density in Taiwanese Elderly Population. International Journal of Environmental Research and Public Health. 2023; 20(4):3448. https://doi.org/10.3390/ijerph20043448

Chicago/Turabian Style

Chung, Pei-Ting, Hsiao-Chi Ma, Sin-Yi Huang, Hsin-Ning Lien, Kuan-Hsun Ho, Hsin-Yin Hsu, Lee-Ching Hwang, Meng-Ting Tsou, Hsin-Hui Lin, and Hsin-Lung Chan. 2023. "Association between Serum Uric Acid Levels and Bone Mineral Density in Taiwanese Elderly Population" International Journal of Environmental Research and Public Health 20, no. 4: 3448. https://doi.org/10.3390/ijerph20043448

APA Style

Chung, P.-T., Ma, H.-C., Huang, S.-Y., Lien, H.-N., Ho, K.-H., Hsu, H.-Y., Hwang, L.-C., Tsou, M.-T., Lin, H.-H., & Chan, H.-L. (2023). Association between Serum Uric Acid Levels and Bone Mineral Density in Taiwanese Elderly Population. International Journal of Environmental Research and Public Health, 20(4), 3448. https://doi.org/10.3390/ijerph20043448

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop