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Review
Peer-Review Record

De-Escalation Strategies for Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma—Where Are We Now?

Curr. Oncol. 2022, 29(5), 3668-3697; https://doi.org/10.3390/curroncol29050295
by Jennifer A. Silver 1,2, Sena Turkdogan 1,2, Catherine F. Roy 1,2, Thavakumar Subramaniam 1,2, Melissa Henry 2,3,4,5 and Nader Sadeghi 1,2,6,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Curr. Oncol. 2022, 29(5), 3668-3697; https://doi.org/10.3390/curroncol29050295
Submission received: 31 March 2022 / Revised: 4 May 2022 / Accepted: 13 May 2022 / Published: 18 May 2022
(This article belongs to the Special Issue Psychosocial Effects of Head and Neck Cancer)

Round 1

Reviewer 1 Report

This is an interesting review about de-escalation strategies for human papillomavirus-associated oropharyngeal squamous cell carcinoma.

The paper is well written. References are adequate. Discussion is appropriate.

I think that the supplementary table should be included in the paper or the authors should include a table summarizing the results.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The manuscript entitled “De-escalation strategies for human papillomavirus-associated oropharyngeal squamous cell carcinoma – Where are we now?” is an interesting review on the alternative therapy regimens or de-escalation strategies in HPV-positive OPSCC patients. The authors focused on the most recent advancements in this field. The study is on a timely subject in view of increasing interest about the quality of life of post-treatment HPV-positive OPSCC patients. I only suggest to briefly discuss the prognosis of HNSCC in young patients, comparing HPV-positive and HPV-negative cancers (for your convenience: doi: 10.1111/odi.13479).

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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